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GPT2 encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis. Additionally we are shipping GPT2 Proteins (16) and GPT2 Kits (6) and many more products for this protein.
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The GPT2 gene demonstrates increasing expression in brain in the early postnatal period, and GPT2 protein localizes to mitochondria. Akin to the human phenotype, Gpt2-null mice exhibit reduced brain growth. Through metabolomics and direct isotope tracing experiments, we find a number of metabolic abnormalities associated with loss of Gpt2
Recessively inherited loss of function GPT2 mutations are a novel cause of intellectual disability.
ATF4 (show ATF4 Antibodies) silencing prevented the activating effect of histidinol and tunicamycin on ATF4 (show ATF4 Antibodies) and ALT2 expression. Our findings point to ALT2 as an enzyme involved in the metabolic adaptation of the cell to stress
expression of GPT2 especially in muscle and fat, suggests a unique and previously unrecognized role of this gene product in glucose, amino acid, and fatty acid metabolism and homeostasis.
The biliary IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects.
Elevation of liver enzymes and hepatic insulin (show INS Antibodies) resistance as reflected by fasting insulin (show INS Antibodies) occur in the early stages of insulin (show INS Antibodies) resistance and highlight the central role of the liver in insulin (show INS Antibodies) resistance in the general population.
A clinical method for selective measurement of ALT1 (show ALT Antibodies) and 2 in human plasma is described.
Data suggest that Alt2/Gpt2 (but not Alt1/Gpt1 (show ALT Antibodies)) is induced in liver of obese mice (male ob/ob mice compared to lean C57BL/6J mice).
This gene encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
alanine aminotransferase 2
, GPT 2
, glutamate pyruvate transaminase 2
, glutamic pyruvate transaminase 2
, glutamic--alanine transaminase 2
, glutamic--pyruvic transaminase 2
, glutamic pyruvate transaminase (alanine aminotransferase) 2
, alanine aminotransferase 2-like
, glutamic-pyruvate transaminase 2