Golgin A2 Proteins (GOLGA2)

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Additionally we are shipping Golgin A2 Antibodies (82) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GOLGA2 99412 Q921M4
GOLGA2 64528 Q62839
GOLGA2 2801 Q08379
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Top Golgin A2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
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Escherichia coli (E. coli) Human Un-conjugated   5 applications 1 to 2 Days
$318.85
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GOLGA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)
Human , ,
,

More Proteins for Golgin A2 (GOLGA2) Interaction Partners

Mouse (Murine) Golgin A2 (GOLGA2) interaction partners

  1. Deletion of GM130 in neurons causes fragmentation.

  2. Therefore, we confirmed the associations among Golgi function, fibrosis, and autophagy. Moreover, GOLGA2 knockout mice may be a potentially valuable animal model for studying autophagy-induced fibrosis.

  3. the GM130-deficient mouse provides a valuable model for investigating the etiology of human globozoospermia.

  4. In oocyte meiosis, GM130 localization and expression patterns are regulated by FMNL1.

  5. GM130 regulates microtubule organization and might cooperate with the MAPK pathway to play roles in spindle organization, migration and asymmetric division during mouse oocyte maturation

Human Golgin A2 (GOLGA2) interaction partners

  1. In situ proximity ligation assays of Golgi localization of alpha-mannosidase IA at giantin versus GM130-GRASP65 site, and absence or presence of N-glycans terminated with alpha3-mannose on trans-Golgi glycosyltransferases may be useful for distinguishing indolent from aggressive prostate cancer cells.

  2. GM130 upregulated expression of the key epithelial-mesenchymal transformation regulator Snail (SNAI1), which mediated EMT activation and cell invasion by GM130.

  3. the study identified GM130 as a novel target of Coxsackievirus B3 (CVB3), which may implicate in the pathogenesis of CVB3-induced acute pancreatitis.

  4. We describe the first human patient with a homozygous apparently loss of function mutation in GOLGA2. The phenotype is a neuromuscular disorder characterized by developmental delay, seizures, progressive microcephaly, and muscular dystrophy.

  5. Data show that WAC directly binds to GM130 and that this binding is required for autophagosome formation through interacting with GABARAP regulating its subcellular localization.

  6. Mutagenesis experiments support these structural observations and demonstrate that they are required for GRASP65-GM130 association.

  7. Depletion of GM130 increases cellular velocity and increases the invasiveness of breast cancer cells, therefore supporting the view that alterations of polarity contribute to tumor progression.

  8. GM130 is a parallel homotetramer with a flexible rod-like structure with I- and Y-shaped conformations.

  9. H-ERG trafficking was impaired by H2O2 after 48 h treatment, accompanied by reciprocal changes of expression between miR-17-5p seed miRNAs and several chaperones (Hsp70, Hsc70, CANX, and Golga20)

  10. Induction of autophagy by shGOLGA2 may induce cell death rather than cell survival. Downregulation of GOLGA2/GM130 may be a potential therapeutic option for lung cancer.

  11. GM130 is involved in the control of glycosylation, cell cycle progression, cell polarization and directed cell migration, according to this review.

  12. FXIII-A associated with podosomes & other structures adjacent to the plasma membrane, containing TGN46 & GM130 but not protein disulphide isomerase. FXIII-A was present in GM130-positive intracellular vesicles that could mediate its transport.

  13. the cytoplasmic C terminus of HERG participates in the tethering or possibly targeting of HERG-containing vesicles within the Golgi via its interaction with GM130

  14. Mammalian Ste20 kinases YSK1 and MST4 target to the Golgi apparatus via the Golgi matrix protein GM130.

  15. Ribbon formation requires the Golgi proteins GM130 and GRASP65.

  16. This is the first report of a role for a Golgi apparatus protein in the regulation of centrosomes during interphase.

  17. depletion of GM130 by RNA interference slows the rate of ER to Golgi trafficking in vivo; interactions of GM130 with syntaxin 5 and Rab1 are regulated by mitotic phosphorylation

  18. Cdc42 has a novel role in controlling centrosome organization in unstimulated cells in addition to its known function as a regulator of centrosome reorientation in stimulated cells.

  19. Data suggest that recruitment of AKAP450 on Golgi membranes through GM130 allows centrosome-associated nucleating activity to extend to the Golgi, to control the assembly of subsets of microtubules.

Golgin A2 (GOLGA2) Protein Profile

Protein Summary

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.

Gene names and symbols associated with Golgin A2 Proteins (GOLGA2)

  • golgin A2 S homeolog (golga2.S)
  • golgin A2 (GOLGA2)
  • golgi autoantigen, golgin subfamily a, 2 (Golga2)
  • golgin A2 (Golga2)
  • AW555139 protein
  • Gm130 protein
  • MGC81213 protein
  • mKIAA4150 protein

Protein level used designations for Golgin A2 Proteins (GOLGA2)

golgin A2 , golgin subfamily A member 2-like , Golgin subfamily A member 2-like , 130 kDa cis-Golgi matrix protein , Golgin subfamily A member 2 , SY11 protein , golgin-95 , cis-Golgi matrix protein GM130 , golgi autoantigen, golgin subfamily a, 2 , GM130 autoantigen , Golgi matrix protein GM130

GENE ID SPECIES
447440 Xenopus laevis
100012662 Monodelphis domestica
100446489 Pongo abelii
100481907 Ailuropoda melanoleuca
100591634 Nomascus leucogenys
100620424 Sus scrofa
99412 Mus musculus
64528 Rattus norvegicus
2801 Homo sapiens
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