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GSC encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. Additionally we are shipping Goosecoid Homeobox Antibodies (93) and many more products for this protein.
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Goosecoid (Gsc), best known for regulating cellular dynamics in the Spemann organizer, regulates delamination of neuroblasts in the otic vesicle.
these data suggest that Lnx (show LNX1 Proteins)-2b maintains the integrity of the ectodermal tissues via suppressing gsc expression which can be driven by the coordinated action of nodal-related factors and Boz.
FoxA3 (show FOXA3 Proteins) and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a (show WNT8A Proteins).
Gsc has dose dependent effects on axis induction and provide new insights into molecularly distinct short- and long-range signaling activities of the organizer.
Performed mutational analysis of TCOF1 (show TCOF1 Proteins), GSC, and HOXA2 (show HOXA2 Proteins) to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome.
We find that DIGIT is divergent to Goosecoid (GSC) and expressed during endoderm differentiation. Deletion of the SMAD3 (show SMAD3 Proteins)-occupied enhancer proximal to DIGIT inhibits DIGIT and GSC expression and definitive endoderm differentiation.
5 genomic variants in GSC, HOXA2 (show HOXA2 Proteins) and PRKRA (show PRKRA Proteins) were identified through mutational analysis in Chinese patients with microtia.
GSC is also a prognostic factor for poor survival and metastasis of HCC (show FAM126A Proteins), which suggests its potential as a therapeutic target for metastatic HCC (show FAM126A Proteins).
Results suggest that GSC is the most potential biomarker of drug response and poor prognosis in ovarian serous carcinomas.
EtOH exposure increased the expression of an organizer specific gene, goosecoid, in human embryonic carcinoma cells.
SAMS (show MAT1A Proteins), a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid.
GSC represses EVX1 expression and is required for development of anterior primitive-streak-like cell progeny in response to activin.
the 4 recently reported SNPs,located near BNC2, SORCS1 (show SORCS1 Proteins), GSC and WDR72 loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 (show SORCS1 Proteins) SNP, findings do not rule out possible relationship with HbA1c
The goosecoid gene mutation in exon 3 may be involved in the malformation events (microtia) in this family.
This study reveals a novel role for Cdh1 (show CDH1 Proteins) in craniofacial development through promoting APC (show APC Proteins)-dependent non-proteolytic ubiquitination and activation of Gsc.
Studies demonstrate that Wwp2 (show WWP2 Proteins) influences craniofacial patterning through its interactions with Goosecoid (Gsc).
Role of gsc in mouse embryogenesis
TFII-I has a role in the regulation of the Gsc gene in response to a TGFbeta/activin signal
Goosecoid promotes tumor cell malignancy and suggest that other conserved organizer genes may function similarly in human cancer
As Gsc is itself induced in a Foxh1 (show FOXH1 Proteins)-dependent manner, we propose that Foxh1 (show FOXH1 Proteins) initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation
These data suggests that regulation of Gsc repressive activity by SUMO modification is promoter specific and may serve to differentially regulate genes that function to control cell morphology during early development and cancer.
Regulatory expression of Goosecoid in P19 embryonal carcinoma cells.
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.
, muenster 72
, goosecoid homeobox
, homeobox protein goosecoid
, zK49F1.1.2 (goosecoid)
, Homeobox protein goosecoid