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GRHL3 encodes a member of the grainyhead family of transcription factors. Additionally we are shipping GRHL3 Antibodies (44) and many more products for this protein.
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Comparison of the variant rate between our cohort and the ExAC database identified a significant enrichment of deleterious variants in GRHL3 in the whole gene and the transactivation region in spina bifida patients. These data provide strong evidence for a role of GRHL3 as a predisposing factor to spina bifida and will help dissect the complex etiology and pathogenic mechanisms of these malformations
All of these processes involve epithelial-mesencyhmal transition (EMT (show ITK Proteins)), MET or a sequence of both, suggesting that the GRHL (show GHRL Proteins) factors((GRHL1 (show GRHL1 Proteins), GRHL2 (show GRHL2 Proteins) and GRHL3), could potentially affect tumor initiation and progression via EMT (show ITK Proteins)
No association found between two GRHL3 SNPs (rs2486668 and rs545809) and non-syndromic orofacial clefts in the Han Chinese cohort.
ey epidermal differentiation transcription factor genes, including GRHL3, are located within super-enhancers, and many of these transcription factors in turn bind to and regulate super-enhancers.
GRHL3 expression may be useful as a prognostic factor.
Study genotyped 10 tag SNPs covering GRHL3 and performed association analysis with nonsyndromic cleft lip with or without cleft palate in 504 cases and 455 healthy controls; preliminary results identified rs10903078, rs4638975, and a haplotype rs10903078-rs6659209 of GRHL3 that exceeded the significance threshold (p<0.05), though none survived Bonferroni correction for multiple comparisons.
findings define a major role for Grhl3 in the induction of migration and invasion by the downregulation of E-cadherin (show CDH1 Proteins) in cancer cells
We discovered a genome-wide significant association with a missense variant in GRHL3 and replicated the result in an independent sample of case and control subjects. In both samples, rs41268753 conferred increased risk for cleft palate.
We identified both rare dominant mutations and a common risk variant in the coding region of GRHL3 as causative in individuals with nonsyndromic cleft palate only.
GRHL1 (show GRHL1 Proteins), GRHL2 (show GRHL2 Proteins), and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]
Findings suggest that transcription factor Grainyhead-like 3 (Grhl3) may be involved in the developmental pathogenesis of craniosynostosis.
Based on the results, it proposes that developmental stage-specific Grhl3 plays a significant role in circumvallate papilla (CVP) morphogenesis not by just disruption of epithelial integrity but by regulating epithelial cell proliferation, apoptosis, and migration via Shh (show SHH Proteins), Wnt (show WNT2 Proteins), and apoptosis signaling during mouse embryogenesis.
Upregulation of miR21 and repression of Grhl3 by leptin (show LEP Proteins) mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.
This study identifies a GRHL3-regulated epidermal barrier repair pathway that suppresses disease initiation and helps resolve existing lesions in immune-mediated epidermal hyperplasia.
decreased Grhl3 expression contributes to tumor progression and upregulation of the oncomir miR (show MLXIP Proteins)-21 in squamous cell carcinoma of the skin.
The developmental transcription factor Grhl3 is a potent tumor suppressor of squamous cell carcinoma in mice.
Both GRHL2 (show GRHL2 Proteins) and GRHL3 bind to and regulate expression of the wound repair gene Rho GEF (show ARHGEF2 Proteins) 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1 (show TGM1 Proteins)), is unique to GRHL3.
maps to Chromosome 4, 135 Mb (66 cM) from the centromere, probably not Idb3 (show ID3 Proteins), Wnt4 (show WNT4 Proteins), Cdc42 (show CDC42 Proteins), perlecan (show HSPG2 Proteins) or Grhl-3
Loss of Grhl3 alone defines a distinct lower spinal closure defect, also with defective dorso-lateral hinge points formation
folate deficiency caused a similar-sized, statistically significant increase in the frequency of exencephaly among both curly tail (Grhl3 mutant) embryos and background-matched embryos that are wild type for Grhl3.
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
grainyhead-like 3 (Drosophila)
, sister-of-mammalian grainyhead protein
, grainyhead-like protein 3 homolog
, sister of mammalian grainyhead
, sister-of-mammalian grainyhead
, transcription factor CP2-like 4
, transcription factor hSOM1
, grainy head-like 3