Granulin (GRN) ELISA Kits

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Antibodies (164) and Granulin Proteins (45) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin ELISA Kits at antibodies-online.com

Showing 9 out of 130 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 1.95 pg/mL 7.8-500 pg/mL Typical standard curve 96 Tests Log in to see 13 to 16 Days
$910.56
Details
Mouse 10pg/mL 0.78-50 ng/mL Mouse Progranulin PicoKine ELISA Kit standard curve 96 Tests Log in to see 4 to 6 Days
$369.00
Details
Rat 0.065 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$800.00
Details
Guinea Pig 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Rabbit 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Pig 0.938 ng/mL 1.563-100 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Chicken 1.875 ng/mL 3.125-200 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Monkey 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Dog 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced Granulin ELISA Kits

  1. Human Granulin ELISA Kit for Sandwich ELISA - ABIN578626 : Qu, Deng, Hu: Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance. in Mediators of inflammation 2013 (PubMed)
    Show all 2 Pubmed References

More ELISA Kits for Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR (show MYLIP ELISA Kits)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP ELISA Kits)-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. SNPs in GRN are not related to ankylosing spondylitis susceptibility in a Chinese Han population.

  2. Plasma progranulin levels predict the presence of GRN null mutations independent of proximity to symptoms and brain atrophy.

  3. Serum progranulin may have potential to be used as a biomarker for the differentiation between early-onset pre-eclampsia and late-onset pre-eclampsia.

  4. CHI3L1 (show CHI3L1 ELISA Kits) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  5. The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin (show INS ELISA Kits) resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.

  6. This work identifies PGRN as an activator of lysosomal cathepsin D (show CTSD ELISA Kits) activity, and suggests that decreased cathepsin D (show CTSD ELISA Kits) activity due to loss of PGRN contributes to both FTD (show FTL ELISA Kits) and NCL pathology in a dose-dependent manner.

  7. MiR (show MLXIP ELISA Kits)-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN.

  8. Results provide evidence that progranulin destabilizes sortilin (show SORT1 ELISA Kits) via ubiquitination and lysosomal degradation to override the negative modulatory functions of sortilin (show SORT1 ELISA Kits) thereby assuring the sustainable pro-tumorigenic actions of progranulin in castration-resistant prostate cancer.

  9. PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]

  10. PGRN regulated its own expression in a positive feedback loop via the AKT (show AKT1 ELISA Kits) and ERK (show EPHB2 ELISA Kits) signaling pathways.

Mouse (Murine) Granulin (GRN) interaction partners

  1. CHI3L1 (show CHI3L1 ELISA Kits) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  2. this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression

  3. PGRN reduction from knock-in R504X mutation disinhibits Gas6 (show GAS6 ELISA Kits) binding to Tyro3 (show TYRO3 ELISA Kits), resulting in activation of PKCalpha (show PKCa ELISA Kits) via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss

  4. PGRN haploinsufficiency may decrease accumulation of Abeta (show APP ELISA Kits).

  5. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  6. Results from conditional progranulin-knockout mice that lack progranulin in nestin (show NES ELISA Kits)-expressing cells (Nes (show NES ELISA Kits)-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  7. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  8. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  9. findings suggest that PGRN deficiency leads to excessive NF-kappaB (show NFKB1 ELISA Kits) activation in microglia and elevated TNFalpha (show TNF ELISA Kits) signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

  10. PGRN plays a protecting role in hippocampal neurogenesis.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 ELISA Kits) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Antigen Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with Granulin (GRN) ELISA Kits

  • granulin precursor (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin L homeolog (grn.L) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin precursor (Grn) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for Granulin (GRN) ELISA Kits

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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