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GDF6 encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. Additionally we are shipping Growth Differentiation Factor 6 Kits (40) and Growth Differentiation Factor 6 Proteins (17) and many more products for this protein.
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Human Polyclonal GDF6 Primary Antibody for WB - ABIN541367
Massagué: The transforming growth factor-beta family. in Annual review of cell biology 1991
Show all 3 Pubmed References
findings indicate that increased BMP signaling owing to a GDF6 gain-of-function mutation is responsible for loss of joint formation and profound functional impairment in patients with Multiple Synostoses Syndrome 4.
As fetal age increased, the expression of growth differentiation factor 6 was decreased correspondingly with the progress of ossification in vertebral bodies and restricted to cartilaginous regions.
BMP13 has a role in enhancing extracellular matrix accumulation and inducing cell migration in certain intervertebral disc cells
GDF6 is overexpressed in Leri's pleonosteosis.
There was a possible weak association between the rs6982567 near GDF6 and polypoidal choroidal vasculopathy in this replication study with an independent Han Chinese cohort.
Deficiency of gdf6 results in photoreceptor degeneration, so demonstrating a connection between Gdf6 signaling and photoreceptor survival.
a critical role of HTRA1 in the regulation of angiogenesis via TGF-beta signaling and identified GDF6 as a novel disease gene for AMD.
studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers
induces ligamentogenic differentiation in mesenchymal progenitors
These data suggest a potential role for BMP-13 (the human homologue to GDF-6) in tendon matrix modeling and/or remodeling.
The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development.
Mutation screening of a large and clinically diverse Klippel-Feil syndrome (KFS) cohort has identified GDF6 missense mutations in both familial and sporadic KFS patients.
These data establish the important role of growth differentiation factor 6 in ocular and vertebral development.
BMP-13 inhibited osteogenic differentiation of bone marrow multipotent mesenchymal stromal cells, implying that functional mutations or deficiency of BMP-13 may allow excess bone formation
Upregulation of Gdf6 restored the osteogenic capacity of old mesenchymal stem cells in vitro and exerted positive effects in vivo on aging-associated pathologies such as reduced lymphopoiesis, insufficient muscle repair, reduced numbers of neural progenitors in the brain, and chronic inflammation.
data indicate that BMP9 and BMP13 (BMP9 might be more effective) promoted the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells
Over-expression of Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage.
Gdf6 plays an inhibitory role to prevent the osteogenic differentiation of the coronal suture mesenchyme
role of single and double mutations in the mouse Gdf6 and Gdf5 genes in multiple joint and skeletal patterning defects
The sequences for complex, regulatory elements responsible for Gdf6 regulation during embryonic skeletal development have been identified.
The role of Gdf6a signaling in superior ocular sulcus morphogenesis.
This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates.
gdf6a is a dorsal initiation signal acting from the extraocular non-neural ectoderm during optic vesicle evagination.
Radar is regulated in the pharyngeal arches by a distant conserved element and has similar functions in skeletal development in fish and mammals.
Maternal induction of bone morphogenetic proteins by Radar is essential for zebrafish development as its removal results in larval-lethal dorsalized phenotypes.
Radar protein expression provides insights into dorsoventral patterning.
Radar is near the top of a signaling cascade that establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map
Gdf6a initiates dorsal retinal patterning independent of Bmp4, and regulates lens differentiation.
GDF6 knockdown in Xenopus results in a high incidence of anterior axial defects consistent with a role for GDF6 in the etiology, diversity, and variability of Klippel-Feil syndrome.
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.
, Klip-Feil malformation
, Klippel-Feil malformation
, Klippel-Feil syndrome
, growth/differentiation factor 16
, growth/differentiation factor 6
, growth differentiation factor 16
, cartilage-derived morphogenetic protein 2
, growth differentiation factor 6
, growth/differentiation factor 6-A
, protein radar
, growth and differentiation factor 6
, growth differentiation factor 6 S homeolog