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GDF6 encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules.
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This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates.
gdf6a is a dorsal initiation signal acting from the extraocular non-neural ectoderm during optic vesicle evagination.
The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development.
These data establish the important role of growth differentiation factor 6 in ocular and vertebral development.
Gdf6a initiates dorsal retinal patterning independent of Bmp4 (show BMP4 Antibodies), and regulates lens differentiation.
findings indicate that increased BMP signaling owing to a GDF6 gain-of-function mutation is responsible for loss of joint formation and profound functional impairment in patients with Multiple Synostoses Syndrome 4.
As fetal age increased, the expression of growth differentiation factor 6 was decreased correspondingly with the progress of ossification in vertebral bodies and restricted to cartilaginous regions.
BMP13 has a role in enhancing extracellular matrix accumulation and inducing cell migration in certain intervertebral disc cells
GDF6 is overexpressed in Leri's pleonosteosis.
There was a possible weak association between the rs6982567 near GDF6 and polypoidal choroidal vasculopathy in this replication study with an independent Han Chinese cohort.
Deficiency of gdf6 results in photoreceptor degeneration, so demonstrating a connection between Gdf6 signaling and photoreceptor survival.
a critical role of HTRA1 (show HTRA1 Antibodies) in the regulation of angiogenesis via TGF-beta (show TGFB1 Antibodies) signaling and identified GDF6 as a novel disease gene for AMD (show AMD1 Antibodies).
studies show that even though tenogenic (BMP 12 (show GDF7 Antibodies) and BMP 13) and osteogenic (BMP2 (show BMP2 Antibodies)) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers
These data suggest a potential role for BMP-13 (the human homologue to GDF-6) in tendon matrix modeling and/or remodeling.
Upregulation of Gdf6 restored the osteogenic capacity of old mesenchymal stem cells in vitro and exerted positive effects in vivo on aging-associated pathologies such as reduced lymphopoiesis, insufficient muscle repair, reduced numbers of neural progenitors in the brain, and chronic inflammation.
data indicate that BMP9 (show GDF2 Antibodies) and BMP13 (BMP9 (show GDF2 Antibodies) might be more effective) promoted the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells
Over-expression of Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage.
Gdf6 plays an inhibitory role to prevent the osteogenic differentiation of the coronal suture mesenchyme
role of single and double mutations in the mouse Gdf6 and Gdf5 (show GDF5 Antibodies) genes in multiple joint and skeletal patterning defects
The sequences for complex, regulatory elements responsible for Gdf6 regulation during embryonic skeletal development have been identified.
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.
growth differentiation factor 6
, growth/differentiation factor 6-A
, protein radar
, Klip-Feil malformation
, Klippel-Feil malformation
, Klippel-Feil syndrome
, growth/differentiation factor 16
, growth/differentiation factor 6
, growth differentiation factor 16
, cartilage-derived morphogenetic protein 2