anti-Growth Differentiation Factor 9 (GDF9) Antibodies

Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Additionally we are shipping GDF9 Kits (55) and GDF9 Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GDF9 2661 O60383
GDF9 14566 Q07105
GDF9 59304  
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Top anti-GDF9 Antibodies at antibodies-online.com

Showing 10 out of 179 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of GDF9 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. AEC was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of GDF9 expression in HL60 (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
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Cow Rabbit Un-conjugated WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB GDF9 Antibody (N-term) (ABIN656116) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-GDF9 N-term Pab (ABIN388822) is used in Western blot to detect GDF9 in HL60 cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma reacted with GDF9 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of GDF9 Antibody (N-term) in K562 cell line lysates (35ug/lane).This demonstrates the GDF9 antibody detected the GDF9 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Phospho-GDF9(Tyr394) in lysates of HL60?, using Phospho-GDF9(Tyr394) Antibody(ABIN6269488). 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Skin (formalin-fixed, paraffin-embedded) stained with GDF9 antibody ABIN214650 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-GDF9 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details

Top referenced anti-GDF9 Antibodies

  1. Human Monoclonal GDF9 Primary Antibody for Func, IHC (fro) - ABIN2473774 : McHugh, Marshall, Ffytche, Hamilton, Raven: Diode laser trabeculoplasty (DLT) for primary open-angle glaucoma and ocular hypertension. in The British journal of ophthalmology 1991 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal GDF9 Primary Antibody for IHC (p), ELISA - ABIN544845 : Aaltonen, Laitinen, Vuojolainen, Jaatinen, Horelli-Kuitunen, Seppä, Louhio, Tuuri, Sjöberg, Bützow, Hovata, Dale, Ritvos: Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. in The Journal of clinical endocrinology and metabolism 1999 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal GDF9 Primary Antibody for IHC (p), WB - ABIN388822 : Hendarto, Prabowo, Moeloek, Soetjipto: Growth differentiation factor 9 concentration in the follicular fluid of infertile women with endometriosis. in Fertility and sterility 2010 (PubMed)
    Show all 2 Pubmed References

More Antibodies against GDF9 Interaction Partners

Zebrafish Growth Differentiation Factor 9 (GDF9) interaction partners

  1. These data suggested that Gdf9 is likely involved in promoting oocyte/ovary differentiation in the zebrafish and it may act by suppressing amh expression, at least partly, in the somatic cells.

  2. GDF9 expression was highest in primary growth follicles and gradually decreased during follicular development. Lowest level was found in fully grown follicles. It was maintained through fertilization and early embryonic development until gastrulation.

Human Growth Differentiation Factor 9 (GDF9) interaction partners

  1. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses their potential role as markers of oocyte quality in women.

  2. Data suggest that GDF9 and BMP15 are oocyte-secreted factors with leading roles in control of ovarian function in female reproduction, modulating both fate of somatic granulosa cells and quality/developmental competence of the egg. (GDF9 = growth and differentiation factor-9; BMP15 = bone morphogenetic protein-15) [REVIEW]

  3. GDF9 single nucleotide polymorphism is not associated with Endometriosis-associated infertility.

  4. GDF9 single nucleotide polymorphism is associated with fecundity.

  5. Asiaticoside hindered the invasive growth of KFs by inhibiting the GDF-9/MAPK/Smad pathway.

  6. Human GDF9 and BMP15 act synergistically to stimulate granulosa cell proliferation, a response that also involves species-specific non-SMAD signalling pathways.

  7. these results indicated that the GDF9 C447T SNP is a possible candidate genetic risk factor for female infertility in the Polish population.

  8. GDF-9 promotes the proliferation and migration of keloid fibroblasts via a mechanism involving the Smad2/3 pathway.

  9. GDF9 c.169G>T (D57Y), c.546G>A (rs1049127), and BMP15 rs79377927 (788_789insTCT) were associated with premature ovarian failure in the Chinese Hui population.

  10. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.

  11. GDF-9 and GDF-15 levels may influence bone parameters in polycystic ovary syndrome

  12. GDF9 and BMP15 expression is reduced in primordial, primary, and secondary follicles in ovarian tissues of PCOS patients.

  13. The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity.

  14. Eleven unique copy number changes are identified in a total of 11 patients, including a tandem duplication of 475 bp, containing part of the GDF9 gene promoter region.

  15. Data suggest up-regulation of mRNA for GDF9 and BMP15 (bone morphogenetic protein 15) in cumulus granulosa cells serves as biomarker for oocyte maturation, fertilization, embryo quality, and pregnancy in couples undergoing ICSI for male infertility.

  16. These results suggest that COCs cultured with recombinant GDF9 in oocyte maturation medium improve oocyte developmental competence and subsequent developmental competence of cloned embryo in cattle.

  17. Reduced expression of growth and differentiation factor-9 is associated with aggressive behaviour of clear-cell renal cell carcinoma.

  18. Oocyte-derived GDF9 does not alter gap junction intercellular communication activity between human granulosa cells.

  19. Alterations to hGDF9 synthesis and activity can contribute to the most common ovarian pathologies.

  20. genetic association studies in population of Han women in China: Data suggest that a mutation in precursor region of GDF9 (R146C) is associated with premature ovarian failure (POF); R146C mutation found in 3 women with POF but absent in controls.

Mouse (Murine) Growth Differentiation Factor 9 (GDF9) interaction partners

  1. Data show that Rac1 induced nuclear import of STAT3 by physical binding, and nuclear STAT3 directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 and BMP15.

  2. In organogenesis of the ovary, production of Dhh/Ihh in granulosa cells requires growth differentiation factor 9 from the oocyte.

  3. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.

  4. The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity during heterodimer formation.

  5. modified oocyte glycoproteins alter GDF9:BMP15 expression modifying follicle development resulting in the generation of more follicles

  6. A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha(-/-) mouse model.

  7. Embryo vitrification has no effect on ovarian morphology or expression of GDF9.

  8. The results show that chronic unpredictable stress suppresses GDF9 expression.

  9. show that purified mature regions of GDF9 and BMP15 synergistically interact in a specific manner which is not dependent on the presence of a pro-region.

  10. GDF9 may contribute to the variation observed in follicular development, ovulation rate, and fecundity between mammals

  11. Data indicate that GDF-9 is absent in follicles of obese anovulatory/PCOS ovaries; upon treatment by heterotopic transplantation of gonadal adipose tissue from lean mice, expression of GDF-9 and ovulation appear to resume.

  12. Integral role of GDF-9 and BMP-15 in ovarian function.

  13. E2 and oocyte-derived paracrine factors GDF9 and bone morphogenetic protein 15 coordinate to promote the development of cumulus cells

  14. The results showed that both GDF-9 and BMP-15 were detectable in oocytes from primary follicles onward, besides, BMP-15 also presented in granulosa cells (GCs) and follicular follicle of mature follicles in mouse

  15. GDF9-stimulated mitogenic activity in granulosa and cumulus cells is mediated through ERK1/2 activity.

  16. Intraovarian excess androgen in polycystic ovary syndrome may result in follicular arrest by down-regulating growth and differentiation factor-9 expression.

  17. Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility.

  18. GNCF-dependent repression of Gdf9 mediates gamete regulation of female fertility.

  19. Growing oocytes and GDF9 can each induce granulosa cells from secondary follicles to shift their phenotype toward that of mural granulosa cells.

  20. GDF9 appears to function indirectly to regulate early granulosa cell proliferation and theca recruitment in vivo

Pig (Porcine) Growth Differentiation Factor 9 (GDF9) interaction partners

  1. These results show that GDF9 and BMP15 participate in cumulus expansion and that they stimulate MPF and MAPK activities in porcine oocytes during in vitro maturation.

  2. Report temporal regulation of GDF9 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.

  3. injection of porcine GDF-9 gene resulted in an increase in the number of primary, secondary and tertiary ovarian follicles

  4. Porcine GDF9 gene was found to be highly expressed in immature oocytes and declined slowly during the oocyte maturation process

  5. GDF9 may be not associated with pig litter size in extensive populations as per the studies of allele distributions of the four polymorphisms and pilot association in four breeds.

Cow (Bovine) Growth Differentiation Factor 9 (GDF9) interaction partners

  1. This study concluded that the improved pregnancy rate after porcine LH-induced ovulation reported previously occurred through greater activation of intrafollicular transforming growth factor-beta1 superfamily members, as these proteins promote cumulus expansion and oocyte competence.

  2. Genetic variability is an important component of the number of antral follicles in the bovine ovary.

  3. Immunization against GDF9 and BMP15, alone or together, altered follicular development and ovulation rate in cattle.

  4. GDF9 expression in the oocytes of calf ovaries was significantly higher than in those of the adult ovaries

  5. GDF-9 mediates its effect through the pathway commonly activated by TGF beta and activin, but not that activated by many BMPs

  6. Maternal GDF9 transcripts persisted during oocyte in vitro maturation and fertilization and in preimplantation embryo until the five- to eight-cell or morula stage, but transcription was not reactivated at the time of embryonic genome activation.

  7. Oocyte- and granulosa cell-derived GDF9 may simultaneously promote theca cell proliferation and prevent premature differentiation of the theca interna during early follicle development.

Rabbit Growth Differentiation Factor 9 (GDF9) interaction partners

  1. In this study, rabbits were distributed into two groups (poor and prolific offspring productions) and cloning and quantitative real-time PCR (qPCR) were employed to characterize the rabbit GDF9 gene. By cloning, 2515-bp genomic DNA and 1359-bp cDNA sequences were obtained

Goat Growth Differentiation Factor 9 (GDF9) interaction partners

  1. an indel mutation in GDF9 is significantly associated with litter size and growth traits in goats

  2. A non-synonymous mutation in GDF9 is highly associated with litter size in Chinese cashmere goats

  3. Studied six SNPs in goat BMPR1B, BMP15, and GDF9 for their association with litter size in seven breeds of Indian goats. Found no association between these SNPs and prolificacy in the breeds investigated.

  4. Expression of BMP15 (p < 0.01) and GDF9 (p < 0.05) mRNAs was more abundant in the small than the large antral follicles of Black Bengal goat.

  5. GNRH1 and GDF9 genes could serve as genetic markers for litter size in goat breeding.

  6. Mutation A959C in GDF9 gene has been associated with prolificacy.

  7. Expression levels of follicular GDF9 and total ovarian BMPR1B were not different between the Lezhi black goat and the Tibetan goat.

  8. These results provide further evidence that the GDF9 gene may be significantly correlated with high prolificacy in goats.

GDF9 Antigen Profile

Protein Summary

Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta superfamily.

Gene names and symbols associated with GDF9

  • growth differentiation factor 9 (GDF9) antibody
  • growth differentiation factor 9 (gdf9) antibody
  • growth differentiation factor 9 (Gdf9) antibody
  • Gdf-9 antibody
  • zgc:123030 antibody

Protein level used designations for GDF9

growth and differentiation factor 9 , growth/differentiation factor 9 , GDF-9 , growth differentiation factor-9

GENE ID SPECIES
100072822 Equus caballus
497643 Danio rerio
2661 Homo sapiens
14566 Mus musculus
59304 Rattus norvegicus
404533 Gallus gallus
100313495 Canis lupus familiaris
414285 Sus scrofa
282574 Bos taurus
100328727 Oryctolagus cuniculus
100735066 Cavia porcellus
100860859 Capra hircus
100217402 Ovis aries
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