Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor) (GUCY2C) ELISA Kits

guanylyl cyclase\; functions as receptor for heat-stable enterotoxin responsible for acute diarrhea [RGD, Feb 2006].. Additionally we are shipping GUCY2C Antibodies (38) and GUCY2C Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GUCY2C 2984 P25092
GUCY2C 14917 Q3UWA6
GUCY2C 25711 P23897
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Top GUCY2C ELISA Kits at antibodies-online.com

Showing 4 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Mouse 9.77 pg/mL 39-2500 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Rat 7.81 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Pig
  96 Tests 15 to 18 Days
$1,029.60
Details

More ELISA Kits for GUCY2C Interaction Partners

Human Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor) (GUCY2C) interaction partners

  1. The results support a role of guanylate cyclase C signaling and disturbed electrolyte homeostasis in development of IBD. Furthermore, downregulation of metallothioneins in the ileal mucosa of familial GUCY2C diarrhea syndrome patients may contribute to inflammatory bowel disease development, possibly alongside effects from NOD2 risk variants.

  2. Human GUCY2C-targeted murine CAR-T cells promoted antigen-dependent T-cell activation quantified by activation marker upregulation, cytokine production, and killing of GUCY2C-expressing, but not GUCY2C-deficient, cancer cells in vitro GUCY2C CAR-T cells provided long-term protection against lung metastases of murine colorectal cancer cells engineered to express human GUCY2C in a syngeneic mouse model.

  3. High Expressions of guanylyl cyclase C is associated with rectal cancer.

  4. The findings support that the activating mutation in GUCY2C creates an intestinal environment with a major influence on the microbiota, which could contribute to the increased susceptibility to inflammatory bowel disease in patients with Familial GUCY2C diarrhea syndrome.

  5. Results demonstrate that GC-C and its ligands, guanylin and uroguanylin are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C signaling pathway may be implicated in the progression of UC.

  6. the expression of GCC is maintained throughout the process of tumor progression and formation of metastatic disease.

  7. To investigate gut motility and hormones before and after a meal in Familial GUCY2C diarrhea syndrome patients and compare with healthy controls

  8. Mutations in GUCY2C indicate a role for this receptor in the pathogenesis of sporadic Congenital secretory diarrhea.

  9. these data support Ad5-GUCY2C-PADRE as a safe and effective vaccination strategy in preclinical models and position Ad5-GUCY2C-PADRE for Phase I clinical testing in colorectal cancer patients.

  10. Familial GUCY2C diarrhoea syndrome is caused by an activating mutation in the GUCY2C gene, which causes impaired contractility and fluid stagnation in the small bowel

  11. Findings show how caloric suppression of the guanylin-GUCY2C signaling axis links obesity to negation of a universal tumor suppressor pathway in colorectal cancer.

  12. Data show that individuals affected with meconium ileus (MI) had either homozygous or compound heterozygous variants in enterotoxin receptor GUCY2C.

  13. High guanylyl cyclase C expression is associated with colon cancer recurrence.

  14. Transmission disequilibrium tests (TDT), case-control studies and quantitative analyses indicated association between GUC2C with Attention-deficit/hyperactivitydisorder and its core symptoms.

  15. Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21.

  16. GUCY2C signaling constitutes a direct link between the initiation of colorectal cancer and the induction of its associated desmoplastic stromal niche.

  17. Data show that lower survival (OS) and disease-free survival (DFS) rates were significantly associated with guanylate cyclase C (GCC) and CK20 mRNA levels.

  18. Interaction with VIP36 is dependent on glycosylation at the same sites that allow GC-C to fold and bind ligand.

  19. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity

  20. Mutations in GUCY2C were associated with the Meconium ileus phenotype. downregulation of GUCY2C leads to a cystic fibrosis-like intestinal phenotype.

Mouse (Murine) Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor) (GUCY2C) interaction partners

  1. Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents.

  2. Relative to controls, guanylate cyclase C knockout mice develop severe systemic illness following oral Salmonella infection, characterized by disrupted intestinal mucus layer, elevated cytokines and organ bacterial load, and reduced animal survival.

  3. Loss of Gucy2c expression is associated with Acute Radiation-Induced GI Syndrome.

  4. Findings show how caloric suppression of the guanylin-GUCY2C signaling axis links obesity to negation of a universal tumor suppressor pathway in colorectal cancer.

  5. The GC-C signaling pathway blunts colonic mucosal inflammation that is initiated by systemic cytokine burst or loss of mucosal immune cell immunosuppression.

  6. GC-C signaling is an essential component of host defense during murine enteric infection by reducing bacterial load and preventing systemic dissemination of attaching/effacing-lesion forming bacterial pathogens such as C. rodentium.

  7. Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21.

  8. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity

  9. The role for GUCY2C-directed CD8(+) T cells targeting specific epitopes in antitumor efficacy.

  10. Data show that silencing of GUCY2C in mice disrupts satiation, resulting in hyperphagia and subsequent obesity and metabolic syndrome.

  11. a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMbeta production

  12. midbrain dopamine neurons express GC-C; GC-C activation potentiates excitatory response mediated by glutamate and acetylcholine receptors via activity of PKG; GC-C knockout mice exhibit hyperactivity and attention deficit

  13. GCC signaling plays a protective role in the integrity of the intestinal mucosal barrier by regulating myosin light chain kinase activation and tight junction disassembly.

  14. There is a previously unappreciated interaction between sex and GCC signaling restricting crypt cell proliferation.

  15. GUCY2C is a tumor suppressor that controls proliferation and metabolism of intestinal epithelial cells by inactivating AKT signaling

  16. transmembrane guanylyl cyclase C is a key mediator of acid-stimulated duodenal bicarbonate secretion

  17. guanylin, uroguanylin, and E coli enterotoxin act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes

  18. two signaling pathways for guanylin peptides in principal cells of mouse cortical kidney collecting duct is not mediated by guanylate cyclase C

  19. Our data demonstrate that Csk is involved in the control of cGMP levels and that membrane-bound guanylyl cyclases can be critically modulated by other receptor-initiated intracellular signaling pathways.

  20. GCC suppresses intestinal tumor initiation and growth by maintaining genomic integrity and restricting proliferation.

GUCY2C Antigen Profile

Antigen Summary

guanylyl cyclase\; functions as receptor for heat-stable enterotoxin responsible for acute diarrhea

Gene names and symbols associated with GUCY2C

  • guanylate cyclase 2C (GUCY2C) antibody
  • guanylate cyclase 2c (Gucy2c) antibody
  • guanylate cyclase 2C (Gucy2c) antibody
  • guanylate cyclase 2C L homeolog (gucy2c.L) antibody
  • guanylate cyclase 2C (gucy2c) antibody
  • AI893437 antibody
  • DIAR6 antibody
  • GC-C antibody
  • GCC antibody
  • GUC2C antibody
  • Gucy2c antibody
  • gucy2c-A antibody
  • MECIL antibody
  • MUCIL antibody
  • STAR antibody

Protein level used designations for GUCY2C

GC-C , STA receptor , guanylyl cyclase C , hSTAR , heat-stable enterotoxin receptor , intestinal guanylate cyclase , heat stable enterotoxin receptor , Guanylate cyclase 2C (heat stable enterotoxin receptor) , guanylate cyclase 2C , guanylate cyclase 2C (heat stable enterotoxin receptor) , heat-stable enterotoxin receptor-like

GENE ID SPECIES
2984 Homo sapiens
282244 Bos taurus
397193 Sus scrofa
14917 Mus musculus
25711 Rattus norvegicus
100135536 Cavia porcellus
378662 Xenopus laevis
417968 Gallus gallus
473375 Pan troglodytes
486671 Canis lupus familiaris
699191 Macaca mulatta
100406002 Callithrix jacchus
100460918 Pongo abelii
100563369 Anolis carolinensis
100594944 Nomascus leucogenys
100008740 Oryctolagus cuniculus
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