anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) Antibodies

HRK encodes a member of the BCL-2 protein family. Additionally we are shipping HRK Kits (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HRK 8739 O00198
HRK 12123 P62816
HRK 117271 P62817
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Top anti-HRK Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-HRK Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Thymus 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg 3 to 4 Days
$289.88
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p) Formalin-fixed and paraffin embedded rat brain tissue labeled with Rabbit Anti-Hrk Polyclonal Antibody, Unconjugated (ABIN2559409) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated WB 50 μg 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg 4 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg 15 to 19 Days
$527.03
Details
Human Rabbit HRP IHC (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
$360.00
Details
Human Rabbit Biotin IHC (p)   100 μL 14 to 21 Days
$394.90
Details

Top referenced anti-HRK Antibodies

  1. Human Polyclonal HRK Primary Antibody for WB - ABIN2474088 : Giroud, Bernard, Guignier, Gras, Bonaiti, Dumas: [Lack of genetic link between the HLA system and idiopathic generalized epilepsy]. in Presse médicale (Paris, France : 1983) 1991 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal HRK Primary Antibody for WB - ABIN541268 : Inohara, Ding, Chen, Núñez: harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). in The EMBO journal 1997 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal HRK Primary Antibody for IHC (p), ELISA - ABIN543406 : Wakabayashi, Kosaka, Hommura: Up-regulation of Hrk, a regulator of cell death, in retinal ganglion cells of axotomized rat retina. in Neuroscience letters 2002 (PubMed)
    Show all 2 Pubmed References

  4. Cow (Bovine) Polyclonal HRK Primary Antibody for WB - ABIN2782598 : Lucas, Milani, Butterworth, Carmell, Scott, Clark, Cohen, Varadarajan: High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. in Leukemia 2016 (PubMed)

  5. Human Polyclonal HRK Primary Antibody for ELISA, WB - ABIN1002403 : Lockshin, Osborne, Zakeri: Cell death in the third millennium. in Cell death and differentiation 2000 (PubMed)
    Show all 3 Pubmed References

More Antibodies against HRK Interaction Partners

Human Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) interaction partners

  1. The apoptosis phenotype was partly dependent on HRK upregulation, as HRK knockdown significantly abrogated the sensitization. KDM2B-silenced tumors exhibited slower growth in vivo. Taken together, our findings suggest a novel mechanism, where the key apoptosis components are under epigenetic control of KDM2B in glioblastoma multiforme cells.

  2. miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent human beta-cell apoptosis.

  3. our findings suggest that induction of the BH3-only protein Hrk is a critical step in 2-ME activation of the JNK-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak.

  4. SUZ12 promotes the proliferation of human EOC cells by inhibiting apoptosis and HRK is a novel SUZ12 target gene whose upregulation contributes to apoptosis induced by SUZ12 knockdown.

  5. Diva binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 proteins, including mouse Harakiri, Bid, Bak and Bmf.

  6. The BH3-only protein harakiri (HRK) is transactivated by ATF4 in severe hypoxia through direct binding of ATF4 to the promoter region.

  7. Data suggest that DP5 and PUMA/BBC3 (p53 up-regulated modulator of apoptosis/bcl-2-binding component 3) contribute to palmitate-induced apoptosis of pancreatic beta-cells via lipotoxic endoplasmic reticulum stress.

  8. These results are used to propose a tentative structural model of how Harakiri works.

  9. analysis of a novel interaction between Bcl-2 members Diva and Harakiri

  10. Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection.

  11. apoptosis inducers as diverse as oncoprotein inhibitors and cell death receptor activators trigger Hrk expression via blockade of DREAM in leukemia cells

  12. Data report that human oocytes and fragmenting preimplantation embryos possess transcripts encoding Harakiri and caspase-3.

  13. HRK is a target of epigenetic inactivation in colorectal and gastric cancer

  14. The interaction between HRK and cellular protein p32 was studied. HRK-induced apoptosis was suppresssed by the expression of p32 mutants lacking the N-terminal sequences 74-282 and the C-terminal sequences 1-221.

  15. HRK appears to be inactivated principally by promoter hypermethylation in prostate cancers and decreased expression may play an important role in tumor progression by modulating apoptotic cell death

  16. in response to PAHs, Ahr-mediated activation of the harakiri, BCL2 interacting protein (contains only BH3 domain), was necessary for execution of cell death.

  17. Aberrant 5'-CpG methylation status and loss of heterozygosity on 12q13.1 are associated with HRK expression in human malignancies, including prostate cancers, astrocytic tumors and primary central nervous system lymphomas. Review.

Mouse (Murine) Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) interaction partners

  1. Hrk deficiency does not significantly attenuate the widespread apoptosis seen in the Bcl-x (-/-) embryonic nervous system, indicating that other BH3-only molecules, alone or in combination, may regulate BAX activation in immature neurons.

  2. DP5 plays an important role in neuronal cell death induced by axotomy and NGF deprivation through the regulation of mitochondrial function and caspase-3 activation

  3. These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells.

  4. in response to PAHs, Ahr-mediated activation of the harakiri, BCL2 interacting protein (contains only BH3 domain), was necessary for execution of cell death.

  5. The effect of antisense oligonucleoties specific to the harakiri mRNA on spontaneous and induced defects of mouse preimplantation embryo development

HRK Antigen Profile

Protein Summary

This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with HRK

  • harakiri, BCL2 interacting protein (HRK) antibody
  • harakiri, BCL2 interacting protein (contains only BH3 domain) (Hrk) antibody
  • harakiri, BCL2 interacting protein (Hrk) antibody
  • AI838259 antibody
  • Bid3 antibody
  • Dp5 antibody
  • harakiri antibody

Protein level used designations for HRK

BCL2-interacting protein , BH3-interacting domain-containing protein 3 , activator of apoptosis Hrk , activator of apoptosis harakiri , death protein 5 , neuronal death protein DP5 , BH3 interacting (with BCL2 family) domain, apoptosis agonist , BH3 interacting domain 3

GENE ID SPECIES
8739 Homo sapiens
12123 Mus musculus
117271 Rattus norvegicus
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