anti-Heat Shock 27kDa Protein 2 (HSPB2) Antibodies

Zebrafish Heat Shock 27kDa Protein 2 (HSPB2) interaction partners

1. hspb2 is expressed during development.

Human Heat Shock 27kDa Protein 2 (HSPB2) interaction partners

1. in differentiating myoblasts, nuclear HSPB2 compartments sequester lamin A.

2. HSPB2 competes with HSPB8 for binding to BAG3. In contrast, HSPB3 negatively regulates HSPB2 association with BAG3.

3. Three of the differentially expressed heat-schock proteins, HSP90A, HSPB1, and HSPB2, are up-regulated in giant cell tumor of bone patients.

4. HspB2 has roles in maintaining ATP levels and as well as chaperone-dependent functions for metabolic homeostasis

5. Results suggest a limited function of alphaB-crystallin and HSP27 in preventing abnormal tau protein deposition in glial cells and neurons; in addition, the expression of alphaB-crystallin phosphorylated at Ser59 may act as a protective factor in glial cells.

6. These findings provide novel insights into the role of p53 as a regulator of bidirectional gene pair HspB2/alpha B-crystallin-mediated ROS and the Warburg effect

7. Study shows that HspB2 oligomers exchange subunits.

8. promoter methylation of heat shock protein B2 is a novel molecular biomarker in human esophageal squamous cell carcinoma

9. Reveal a novel function of HspB2 as an anti-apoptotic protein that negatively regulates apical caspase 3/8 activation in the extrinsic apoptotic pathway.

10. Hsp27, but not the classic Hsp60 and Hsp70, may be associated with the development bronchiolitis obliterans syndrome.

11. Sodium salicylate can induce the expression of HSP27 in human lens epithelial cells.

12. Both heat and BPDE can induce the expressions of Hsp27 and Hsp70 in A549 cells.

13. analysis of CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients

14. HSP27 is linked to multi-drug resistance in cell line HepG2/VCR.

15. The abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with lymph node metastasis in colorectal cancer.

16. 5-fluorouracil & carboplatin specifically induce expression of Hsp27 in hepatoma cells. siRNA knockdown of Hsp27 diminishes survival of drug-exposed cells.

17. HSP27 confers reresistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E

18. PM induces ROS generation in human lung endothelium, resulting in oxidative stress-mediated EC barrier disruption via p38 MAPK- and HSP27-dependent pathways.

19. study indicate that monocytes do not trigger apoptosis of vascular endothelial cells; proapoptotic activation mediated by PUMA seemed to be counterbalanced by significant increase of antiapoptotic HSP70, HSP27 and especially phospho-HSP27 proteins level

20. HSP27 and p53 protein levels play a key role(s) in heat shock-mediated switch of glucose depreivation-induced necrosis to apoptosis.

Mouse (Murine) Heat Shock 27kDa Protein 2 (HSPB2) interaction partners

1. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

2. We found significantly slower retrograde transport of mitochondria in Ser135Phe, Pro39Leu and Arg140Gly mutant Hsp27 expressing motor neurons than in wild type Hsp27 neurons, although anterograde movement velocities remained normal.

3. HSP27 expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 modulates lung fibroblast differentiation through the Smad3 and ERK pathways.

4. phosphorylated Hsp27 stimulates autophagy and lipid droplet clearance and interacts with STAT3.

5. Heat shock proteins 27 and 70 were involved in the protective effect.

6. The phosphorylation of S82 of the heat shock protein 27 kDa (HSP27), was especially abundant and consistently upregulated in tissues with delays in freezing as short as 2 minutes.

7. HspB2 has roles in maintaining ATP levels and as well as chaperone-dependent functions for metabolic homeostasis

8. Hsp27 binding to the 3'UTR of Bim mRNA prevents neuronal death during oxidative stress-induced injury.

9. These findings indicate that in mice HSP27 and HSP70 play a key role in the induction of cell-mediated immunity to carcinogenic polyaromatic hydrocarbons

10. The myocardium releases HSP27 after global ischemia: the proinflammatory effect of extracellular HSP27 through TLR2 and TLR4.

11. protective role for endothelial S1P1R against ischemic acute kidney injury most likely by regulating endothelial barrier integrity and endothelial HSP27 expression

12. It plays a protective role against AP-induced liver injury.

13. findings reveal a novel role for HSP27 in the maintenance of BBB integrity.

14. Spatial learning was impaired in AD model mice rescued by Hsp27 overexpression.

15. HSP27 is increased in hyperlipidemic animals treated with reconstituted high-density lipoprotein.

16. Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-kappaB signaling.

17. Chronic over-expression of HSP27 is atheroprotective in both sexes and coincides with reductions in lesion cholesterol accumulation as well as favorable plaque remodeling.

18. Tubular expression of heat-shock protein 27 inhibits fibrogenesis in obstructive nephropathy.

19. activation of PP2A or inactivation of the p38MAPK-MAPKAPK2-Hsp27 has a role in survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity

20. HSPB2 can be replaced by other members of the multigene small HSP family under basal conditions while HSPB2 is implicated in the regulation of metabolic/mitochondrial function under cardiac stress such pressure overload.