anti-Hepatic Leukemia Factor (HLF) Antibodies

HLF encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. Additionally we are shipping HLF Proteins (6) and HLF Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HLF 217082 Q8BW74
HLF 3131 Q16534
HLF 690286  
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Top anti-HLF Antibodies at

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Hlf Antibody Titration: 1.0 ug/ml Positive Control: Mouse Testis 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-HLF Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Hela cell lysate 100 μL 2 to 3 Days
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of HLF using HeLa whole  lysates. ABIN6278024 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11 to 12 Days
Human Rabbit Un-conjugated WB Western blot analysis of extract of mouse liver and mouse brain cells, using HLF antibody. 100 μL 11 to 13 Days
Dog Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Mouse Un-conjugated IF, RNAi, ELISA, WB Western Blot analysis of HLF expression in transfected 293T cell line by HLF monoclonal antibody (M04), clone M2.Lane 1: HLF transfected lysate(33.2 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of monoclonal antibody to HLF on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
Human Rabbit Un-conjugated WB Western Blot at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: SH-SY5Y whole cell lysate Lysates/proteins at 20 ug per lane. 400 μL 2 to 3 Days
Mouse Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using HLF antibody (ABIN5971611) at 1/1000 dilution. 100 μL 11 to 16 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using HLF antibody. 200 μL 12 to 14 Days

Top referenced anti-HLF Antibodies

  1. Human Monoclonal HLF Primary Antibody for IF, RNAi - ABIN561276 : Murakami, Higashi, Matsunaga, Koyanagi, Ohdo: Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice. in Gastroenterology 2008 (PubMed)

More Antibodies against HLF Interaction Partners

Mouse (Murine) Hepatic Leukemia Factor (HLF) interaction partners

  1. HLF-deficient hematopoietic stem cells display loss of quiescence and increased sensitivity to chemotoxic insults.

  2. Results demonstrate that Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations and that modulation of the pyridoxine pathway can also influence phenotype severity

  3. Conditional expression of E2A-HLF induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.

  4. Data indicate that Meis homeobox 1 (MEIS1) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1.

  5. we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure

  6. mice deficient for all three PAR bZip proteins (DBP,HLF,& TEF) are highly susceptible to generalized spontaneous and audiogenic epilepsies, frequently lethal. Pyridoxal kinase is a target gene of PAR bZip proteins in both liver and brain

  7. The HLF protein control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR).

  8. Data show that the clock knockout mice or mice devoid of dbp/hlf/tef (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance.

Human Hepatic Leukemia Factor (HLF) interaction partners

  1. Our findings uncovered HLF as a novel oncofetal protein and revealed the crucial role of the HLF/c-Jun axis in HCC development and sorafenib response, rendering HLF as an optimal target for the prevention and intervention of HCC

  2. Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.

  3. HLF-mediated miR-132 directly suppresses TTK expression, thus exerting inhibitory effects on cancer cell proliferation, metastasis and radioresistance.

  4. Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3-HLF ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids.

  5. ectopic expression of HLF, an established transcription factor that cycles with circadian rhythms, can recapitulate many features associated with circadian-dependent physiological variation.

  6. both Lmo2 and Bcl-2 are required for the action of E2A-HLF in leukemogenesis

  7. E2A-HLF promotes cell survival of t(17;19)- acute lymphoblastic leukemia cells by aberrantly up-regulating LMO2 expression

  8. Evidence pertaining to leukemogenesis by the well-characterized oncogenic fusion protein E2A-HLF is reviewed and its mechanistic implications are considered.

  9. E2A-HLF induces annexin II by substituting for cytokines that activate downstream pathways of Ras

  10. The E2A-HLF-mediated over-expression of ABCB1 may play a role in the clinical phenotype of ALLs with a t(17;19), suggesting pharmacologic modulation of ABCB1 activity as a rational therapeutic strategy for this chemotherapy resistant subtype of ALL.

  11. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: E2A/PBX1 and E2A/HLF.

  12. In childhood acute lymphoblastic leukemia and hypercalcemia, translocation was observed in E2A-HLF fusion protein.

  13. Activation of the thyroid hormone receptor beta/retinoid X receptor alpha heterodimer by T(3) stimulated expression of the hepatic leukemia factor, which increases HIF-1alpha gene expression.

  14. The authors characterize variants of rat HLF, including use of two alternative promoters and a non-AUG translation initiation site that has not been confirmed in human.

HLF Antigen Profile

Protein Summary

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with HLF

  • HLF, PAR bZIP transcription factor (HLF) antibody
  • hepatic leukemia factor (Hlf) antibody
  • hepatic leukemia factor a (hlfa) antibody
  • Hepatic leukemia factor (Bm1_18395) antibody
  • Hepatic leukemia factor (hlf) antibody
  • HLF, PAR bZIP transcription factor (Hlf) antibody
  • DKFZp469P0721 antibody
  • E230015K02Rik antibody
  • Hlf antibody
  • HLF1 antibody
  • zgc:153035 antibody

Protein level used designations for HLF

hepatic leukemia factor , hepatic leukemia factor 1 , zhlf1 , Hepatic leukemia factor

706623 Macaca mulatta
516069 Bos taurus
217082 Mus musculus
100192429 Ovis aries
100171535 Pongo abelii
593063 Strongylocentrotus purpuratus
417395 Gallus gallus
455140 Pan troglodytes
3131 Homo sapiens
768192 Danio rerio
6098588 Brugia malayi
100380463 Salmo salar
100724740 Cavia porcellus
690286 Rattus norvegicus
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