anti-Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) Antibodies

HNRNPA1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping Heterogeneous Nuclear Ribonucleoprotein A1 Kits (19) and Heterogeneous Nuclear Ribonucleoprotein A1 Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HNRNPA1 3178 P09651
HNRNPA1 15382 P49312
HNRNPA1 29578 P04256
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Top anti-Heterogeneous Nuclear Ribonucleoprotein A1 Antibodies at antibodies-online.com

Showing 10 out of 143 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-HNRPA1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  Jurkat cell lysate HNRNPA1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit Anti-HNRPA1 Antibody  Paraffin Embedded Tissue: Human Heart Cellular Data: Myocardial cells Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated IHC (p), WB HnRNP A1 was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- HnRNP A1 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). HnRNP A1 was detected in paraffin-embedded sections of human placenta tissues using rabbit anti- HnRNP A1 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-HNRPA1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate HNRNPA1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells ARP40384 Paraffin Embedded Tissue: Human Intestine Cellular Data: Epithelial cells of intestinal villas Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using HNRNPA1 antibody (ABIN5975570) at 1/200 dilution. Immunohistochemistry of paraffin-embedded human gastric injury using HNRNPA1 Antibody (ABIN5975570) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days
$426.40
Details
Mouse Mouse Un-conjugated ICC, FACS, IF, IHC (p), IP, ELISA, WB Western blot for anti-hnRNP-A1 on HeLa cell extracts 50 μL 7 to 8 Days
$447.65
Details
Chicken Rabbit Un-conjugated IC, IF, IP, IHC, WB Immunofluorescent analysis of hnRNP A1 staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of hnRNP A1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6268816 at 1/100 staining human brain tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of hnRNP A1 expression in 293 cell extract 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image hnRNP A1 antibody detects HNRNPA1 protein by Western blot analysis. A. 30 µg PC-12 whole cell lysate/extract 12 % SDS-PAGE hnRNP A1 antibody , dilution: 1:1000 WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 10% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from 293/Jurkat/COLO205 cells, using hnRNP A1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using hnRNP A1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using hnRNP A1 Polyclonal Antibody. 100 μL Available
$363.46
Details

Top referenced anti-Heterogeneous Nuclear Ribonucleoprotein A1 Antibodies

  1. Cow (Bovine) Monoclonal HNRNPA1 Primary Antibody for ICC, IF - ABIN152096 : Izaurralde, Jarmolowski, Beisel, Mattaj, Dreyfuss, Fischer: A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. in The Journal of cell biology 1997 (PubMed)
    Show all 21 Pubmed References

  2. Mouse (Murine) Monoclonal HNRNPA1 Primary Antibody for ICC, FACS - ABIN108610 : Matunis, Xing, Dreyfuss: The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. in Nucleic acids research 1994 (PubMed)
    Show all 10 Pubmed References

  3. Mouse (Murine) Monoclonal HNRNPA1 Primary Antibody for ICC, FACS - ABIN108609 : Burd, Dreyfuss: RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. in The EMBO journal 1994 (PubMed)
    Show all 10 Pubmed References

  4. Cow (Bovine) Polyclonal HNRNPA1 Primary Antibody for IHC, WB - ABIN2778789 : Xia: Regulation of gamma-fibrinogen chain expression by heterogeneous nuclear ribonucleoprotein A1. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal HNRNPA1 Primary Antibody for ICC, IF - ABIN108584 : Piñol-Roma, Choi, Matunis, Dreyfuss: Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. in Genes & development 1988 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal HNRNPA1 Primary Antibody for ICC, IF - ABIN108583 : Guil, Cáceres: The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. in Nature structural & molecular biology 2007 (PubMed)
    Show all 3 Pubmed References

  7. Human Polyclonal HNRNPA1 Primary Antibody for IF, IHC - ABIN6141896 : Wang, Fu, Chen, Wu, Fan, Li, Zhu, Jia, Ji, Wang, Wong, Hu, Hui: SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling. in Cell research 2017 (PubMed)
    Show all 2 Pubmed References

  8. Monoclonal HNRNPA1 Primary Antibody for IF, IP - ABIN534212 : Turunen, Verma, Nyman, Frilander: HnRNPH1/H2, U1 snRNP, and U11 snRNP cooperate to regulate the stability of the U11-48K pre-mRNA. in RNA (New York, N.Y.) 2013 (PubMed)
    Show all 3 Pubmed References

  9. Human Polyclonal HNRNPA1 Primary Antibody for IF, IHC - ABIN6681497 : Wei, Dai, Zhou, He, Yao, Zhao, Guo, Yang: Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. in Cell death & disease 2018 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Heterogeneous Nuclear Ribonucleoprotein A1 Interaction Partners

Human Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) interaction partners

  1. Report direct role for hnRNPA1 in MYLK alternative splicing in lung endothelial cells.

  2. HNRNPA1 3'UTR was most pervasively mis-spliced in pediatric B-cell acute lymphoblastic leukemia, yielding the transcript subject to nonsense-mediated decay.

  3. Study identified the reversible amyloid-forming cores of hnRNPA1 (named hnRACs). The atomic structures of hnRACs reveal a distinct feature of stacking Asp residues, which contributes to fibril reversibility and explains the irreversible pathological fibril formation caused by the Asp mutations identified in familial amyotrophic lateral sclerosis.

  4. REVIEW: available structural biochemical developments of hnRNP A1-RNA recognition, as a framework to interpret its wide-range of RNA functions

  5. Moreover, SRSF10, hnRNP A1/A2 and Sam68 collaborate to drive the DNA damage-induced splicing response of several transcripts that produce components implicated in apoptosis, cell-cycle control and DNA repair.

  6. By using an integrative structural biology approach, we show that hnRNP A1 forms a 1:1 complex with pri-mir-18a where both RNA recognition motifs (RRMs) bind to cognate RNA sequence motifs in the terminal loop of pri-mir-18a.

  7. Data suggest that one way heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) regulates exon definition is to modulate the interaction of U2 small nuclear RNA auxiliary factor 2 (U2AF2) with decoy or bona fide 3' splice site (3'ss).

  8. Our results indicate that hnRNP A1 promotes cell survival and cell cycle progression following UVB radiation

  9. These findings indicated that hnRNPA1 is highly expressed in gastric cancer (GC)and promoted invasion by inducing Epithelialtomesenchymal transition (EMT) in GC cells. Thus, hnRNPA1 may be a potential therapeutic target for GC.

  10. A significant overlap between hnRNPA1 and DDX5 splicing targets and they share many closely linked binding sites.

  11. Results suggest that telomeric repeat-containing RNA (TERRA) regulates binding of heterogeneous nuclear ribonucleoprotein A1 to the telomere in a region surrounding the telomere, leading to a deeper understanding of the mechanism of TERRA function.

  12. mutation in HNRNPA1 located in the nuclear localization signal domain of hnRNPA1, enhances the recruitment of mutant hnRNPA1 into stress granules, indicating that an altered nuclear localization signal activity plays an essential role in amyotrophic lateral sclerosis pathogenesis.

  13. Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution have been described.

  14. study showed that UVB induces alternative splicing of hdm2 by increasing the expression and the binding of hnRNP A1 to hdm2 full-length mRNA

  15. The authors show by NMR spectroscopy that both RNA recognition motifs of hnRNP A1 can bind simultaneously to a single bipartite motif of the human intronic splicing silencer ISS-N1, which controls survival of motor neuron exon 7 splicing.

  16. current knowledge of the involvement of hnRNPA1 in cancer, including its roles in regulating cell proliferation, invasiveness, metabolism, adaptation to stress and immortalization.

  17. Case Report: inflammatory myofibroblastic tumor (IMT) of the urinary bladder with a novel HNRNPA1-ALK fusion.

  18. EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1.

  19. hnRNP A1 directly binds to the 5' untranslated region of the RON mRNA and activates its translation through G-quadruplex RNA secondary structures

  20. We demonstrate that the wild-type sequence harbors an hnRNP A1 and hnRNP A2/B1-binding exonic splicing silencer (ESS) overlapping the 5'splice site (5'ss) that prevents pseudoexon inclusion.we demonstrate that splice switching oligonucleotide (SSO) mediated blocking of the pseudoexon 3'ss and 5'ss effectively restores normal GLA splicing

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) interaction partners

  1. Report direct role for hnRNPA1 in MYLK alternative splicing in lung endothelial cells.

  2. Knockdown of hnRNP A1 led to a decrease in endogenous Nfil3 protein level, which could be due to a reduction in IRES-mediated translation.

  3. Study demonstrated that hnRNPA1 plays a critical and irreplaceable role in embryonic muscle development by regulating the expression and alternative splicing of muscle-related genes.

  4. hnRNPA1 is a critical regulator of vascular smooth muscle cell function and behavior in the context of neointima hyperplasia via miR-124/IQGAP1 regulatory axis.

  5. PRMT5 regulates internal ribosome entry site-dependent translation via methylation of hnRNP A1.

  6. Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1.

  7. this study identified hnRNPA1, an RNA-binding protein and auxiliary splicing factor, as a substrate of TRAF6; TRAF6 ubiquitination of hnRNPA1 regulated alternative splicing of Arhgap1, which resulted in activation of the GTP-binding Rho family protein Cdc42 and accounted for hematopoietic defects in TRAF6-expressing hematopoietic stem/ progenitor cells

  8. A1 and A2/B1, which are required for transcript degradation

  9. hnRNP A1 improves intestinal injury in anti-CD3 antibody-induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration

  10. Relevant to biological processes anticipated for hnRNP A1 and HuR.

  11. This study provides evidence that PCBP2 and hnRNP A1 bind to the 5' and 3' ends of the murine norovirus 1 viral RNA and contribute to RNA circularization, playing a role in the virus life cycle.

  12. Heteronuclear ribonucleoprotein A1 interacts with an element that overlaps the 5' splice site of Mag exon 12.

  13. MMP-3-triggered Rac1 splicing regulation is modulated by hnRNP A1

  14. the phosphorylation status of hnRNP A1 serine 199 regulates the AKT-dependent sensitivity of cells to rapamycin and functionally links IRES-transacting factor annealing activity to cellular responses to mTOR complex 1 inhibition.

  15. eIF2alpha phosphorylation during hypertonic stress promotes apoptosis by sequestration of specific mRNAs in SGs in a process mediated by the cytoplasmic accumulation of hnRNP A1

  16. splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression

  17. data provide evidence that hnRNP A1 is directly or indirectly involved in mouse hepatitis virus RNA transcription and replication

  18. study provides direct in vivo evidence demonstrating a functional role for hnRNP A1 in mouse hepatitis virus RNA synthesis

  19. results are consistent with a model in which the binding of hnRNP A1 to the 71 nt putative hairpin-loop region in the CYP2A5 mRNA 3' UTR upregulates mRNA levels possibly by protecting the mRNA from degradation

  20. Both hnRNP A1 and alternative splicing factor/splicing factor 2 contents rose in adenomas and during injury-induced hyperplasia compared to control lungs

Pig (Porcine) Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) interaction partners

  1. the swine HNRPA1 gene was moderately expressed in fat, spleen and kidney, weakly expressed in muscle and lung, and hardly expressed in small intestine, large intestine and liver.

Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) Antigen Profile

Protein Summary

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.

Gene names and symbols associated with HNRNPA1

  • heterogeneous nuclear ribonucleoprotein A1b (hnrnpa1b) antibody
  • heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) antibody
  • heterogeneous nuclear ribonucleoprotein A1 (LOC100101226) antibody
  • Heterogeneous nuclear ribonucleoprotein A1 (roa1) antibody
  • heterogeneous nuclear ribonucleoprotein A1 S homeolog (hnrnpa1.S) antibody
  • heterogeneous nuclear ribonucleoprotein A1 (hnrnpa1) antibody
  • heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1) antibody
  • heterogeneous nuclear ribonucleoprotein A1-like (LOC100359118) antibody
  • ribonucleoprotein A1a (hnrnpa1) antibody
  • D15Ertd119e antibody
  • Hdp antibody
  • hnrnp-A1 antibody
  • HNRNPA1 antibody
  • hnRNP A1 antibody
  • Hnrpa1 antibody
  • HNRPA1L3 antibody
  • ROA1 antibody
  • TPT1P antibody

Protein level used designations for HNRNPA1

heterogeneous nuclear ribonucleoprotein A1 , hnRNP core protein A1 , helix-destabilizing protein , single-strand-binding protein , hormonally upregulated Neu-associated kinase , Heterogeneous nuclear ribonucleoprotein A1 , heterogeneous ribonuclear particle protein , hnRNP A1 , Putative heterogeneous nuclear ribonucleoprotein A1-like 3 , heterogeneous nuclear ribonucleoprotein A1B protein , heterogeneous nuclear ribonucleoprotein B2 protein , heterogeneous nuclear ribonucleoprotein core protein A1 , hnRNP A1-like 3 , hnRNP core protein A1-like 3 , nuclear ribonucleoprotein particle A1 protein , single-strand DNA-binding protein UP1 , single-strand RNA-binding protein , HDP-1 , helix destabilizing protein , topoisomerase-inhibitor suppressed , UP1 , unwinding protein 1 , HDP , hnRNP A1-gamma isoform , heterogeneous nuclear ribonucleoproteins A1 homolog

GENE ID SPECIES
378453 Danio rerio
739306 Pan troglodytes
100101226 Bombyx mori
100195734 Salmo salar
380381 Xenopus laevis
496507 Xenopus (Silurana) tropicalis
3178 Homo sapiens
15382 Mus musculus
768103 Sus scrofa
505093 Bos taurus
29578 Rattus norvegicus
100359118 Oryctolagus cuniculus
100726972 Cavia porcellus
747284 Pan troglodytes
702977 Macaca mulatta
397751 Xenopus laevis
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