HEXIM2 can functionally and quantitatively compensate for the loss of HEXIM1
utilization of HEXIM1 or HEXIM2 to bind and inhibit P-TEFb can be differentially regulated in vivo.
Positive transcription elongation factor b regulates eukaryotic gene expression at the level of elongation and is controlled by the reversible association with HEXIM2.
The tripartite protein-RNA complex formation between Hexim, Cyclin T and 7SK snRNA, was analyzed.
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity).
MAQ1 paralog , hexamethylene bis-acetamide-inducible protein 2 , hexamethylene-bis-acetamide-inducible transcript 2 , hexamthylene bis-acetamide inducible 2 , protein HEXIM2
GENE ID | SPECIES |
---|---|
124790 | Homo sapiens |
71059 | Mus musculus |
614679 | Bos taurus |