High Mobility Group Nucleosome Binding Domain 5 Proteins (HMGN5)

HMGN5 encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. Additionally we are shipping HMGN5 Antibodies (44) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HMGN5 79366 P82970
HMGN5 681284 B4F777
HMGN5 50887 Q9JL35
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top HMGN5 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$3,197.33
Details

HMGN5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for High Mobility Group Nucleosome Binding Domain 5 (HMGN5) Interaction Partners

Human High Mobility Group Nucleosome Binding Domain 5 (HMGN5) interaction partners

  1. MiR-183-3p regulated HMGN5 expression in prostate cancer cells.

  2. Findings suggest that a miR-140-5p/HMGN5/autophagy regulatory loop plays a critical role in chemoresistance in osteosarcoma. In conclusion, our data elucidated that miR-140-5p promoted autophagy mediated by HMGN5 and sensitized osteosarcoma cells to chemotherapy.

  3. High HMGN5 expression is associated with osteosarcoma invasion.

  4. We observed decreased miR-409-3p expression in glioma, and overexpression of miR-409-3p repressed glioma cell invasion and proliferation by targeting HMGN5, an oncogene associated with glioma

  5. HMGN5 regulated the expression of multidrug resistance 1, cyclin B1, and Bcl-2.

  6. NSBP1 was highly expressed in NSCLC cells. NSBP1 siRNA knockdown suppressed NSCLC cell proliferation and invasion. miR326 has a putative binding site in the NSBP1 3'UTR. NSBP1 overexpression abolished miR326 inhibition of cyclin B1 and MMP9 expression.

  7. HMGN5 overexpression is correlated with advanced pathological grade and poorer prognosis in meningiomas

  8. Decreased miR-340 expression may contribute to the development and progression of prostate cancer through a mechanism that involves HMGN5.

  9. Our data first time identified miR-186 as the upstream regulator of NSBP1

  10. High HMGN5 expression is associated with urothelial bladder cancer.

  11. HMGN5 is an oncogene and plays an important role in prostate cancer tumorigenesis and progression. the level of HMGN5 may be used as a biomarker to predict the patients that would benefit from gemcitabine treatment.

  12. HMGN5 plays an oncogenic role in human breast cancer by inhibiting cell proliferation and invasion, and activating apoptosis, which could be exploited as a target for therapy in human breast cancer.

  13. HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation

  14. HMGN5 plays oncogenic role in osteosarcoma by promoting cell proliferation and invasion, and could be exploited as a target for therapy in osteosarcoma.

  15. HMGN5 is a critical factor in the development of chemoresistance through regulating autophagy, and it offers a novel target for improving osteosarcoma therapy.

  16. Data indicate that cells lacking either high mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner.

  17. HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation.

  18. HMGN5 may be a potential molecular target with therapeutic relevance for the treatment of prostate cancer.

  19. NSBP1 plays oncogenic role in clear cell renal cell carcinoma (ccRCC) by promoting cell proliferation and invasion.

  20. The data of study suggested that HMGN5 may play a critical role in the development of gliomas.

Mouse (Murine) High Mobility Group Nucleosome Binding Domain 5 (HMGN5) interaction partners

  1. Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2.

  2. Mice overexpressing HMGN5, either globally or only in the heart, are normal at birth but develop hypertrophic heart with large cardiomyoctyes, deformed nuclei and disrupted lamina, and die of cardiac malfunction.

  3. HMGN5 overexpression induces neurite outgrowth.

  4. functional loss of HMGN5 leads to changes in transcription of Gpx6 and Hk1 that alter glutathione metabolism.

  5. Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities.

  6. Downregulation of NSBP1 reduced the cancer growth rate, whereas tumourigenicity was not influenced.

  7. NSBP1 is an architectural protein that binds preferentially to euchromatin and modulates the fidelity of the cellular transcription profile by counteracting the chromatin-condensing activity of linker histones.

HMGN5 Protein Profile

Protein Summary

This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein.

Gene names and symbols associated with HMGN5

  • high mobility group nucleosome binding domain 5 (HMGN5)
  • high mobility group nucleosome binding domain 5B (Hmgn5b)
  • high-mobility group nucleosome binding domain 5 (Hmgn5)
  • GARP45 protein
  • Hmgn5 protein
  • Hmgn5l1 protein
  • NBP-45 protein
  • Nsbp1 protein

Protein level used designations for HMGN5

high mobility group nucleosome-binding domain-containing protein 5 , high-mobility group nucleosome binding domain 5 , nucleosomal binding protein 1 , nucleosome-binding protein 1 , high-mobility group nucleosome binding domain 5-like 1 , nucleosome binding protein 1 , nucleosome binding protein 45

GENE ID SPECIES
79366 Homo sapiens
681284 Rattus norvegicus
50887 Mus musculus
Selected quality suppliers for HMGN5 Proteins (HMGN5)
Did you look for something else?