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Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons.
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H1R (show HRH1 Antibodies) and H4R are useful biomarkers of allergic inflammation on the ocular surface. Most notably, H4R expressed on eosinophils is useful as a biomarker of eosinophilic inflammation of the ocular surface.
Histamine stimulation influences the IL-17 (show IL17A Antibodies) pathway in psoriasis via the fourth histamine receptor subtype, H4R, on CD4 (show CD4 Antibodies)+ T cells.
This study suggests that genetic variations within the HRH4 gene might be associated with special clinical features of psoriasis.
Our findings provide evidence that HRH4 rs77485247 and rs77041280 polymorphisms may be associated with the risk of allergic rhinitis (AR) and the efficacy of H1 antihistamines for the treatment of AR patients.
These data imply that the H4R regulates IgE-dependent processes in human basophils and provides a novel function of the H4R preventing an overwhelming immune reaction by engagement of a negative feedback loop.
Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells
Histamine H4 receptors could not be identified in five experimental models of the guinea-pig that are suited for the detection of presynaptic inhibitory receptors (hippocampus aorta, atrium, renal cortex and vas (show AVP Antibodies) deferens) whereas H3 receptors could be shown in the peripheral tissues but not in the hippocampus
Taken together these data demonstrate that compound A and compound L may block H4R-mediated downstream signaling events.
We also found that the activation of H4R caused the release of IL-13 (show IL13 Antibodies) and RANTES (show CCL5 Antibodies) on human mast cells.these data demonstrate that the H4R activates divergent signaling pathways to induce cytokine and chemokine (show CCL1 Antibodies) production in human mast cells
H4R may be involved in the maintenance of healthy oral mucosa. In oral lichen planus, this maintenance might be impaired by mast cell degranulation and inflammatory cytokines.
H4R ligands have a beneficial effect in a model of lung fibrosis in the mouse, thus indicating that H4R antagonists or inverse agonists could be a novel therapeutic strategy for lung inflammatory diseases.
Results illustrate that histamine H4 receptors (H4R) modulates various neurophysiological functions such as locomotor activity, anxiety, nociception and feeding behaviour, confirming the importance of the integrity and functionality of neuronal H4R in the histaminergic regulation of neuronal functions.
These results identify the H4R as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation. These results further suggest that blocking the H4R in the skin might be beneficial in diseases like atopic dermatitis.
Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis
These results indicate a proinflammatory role of histamine via H4R in inflammatory bowel disease.
The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.
H4R expression on murine keratinocytes was detected after stimulation with LPS (show TLR4 Antibodies) and peptidoglycan.
the present study shows that H4 receptors potentially play a role in IgE induced FcepsilonRI (show FCER1A Antibodies) upregulation
Acting via its H4 receptors, histamine impedes lipopolysaccharide-induced microglia migration and interleukin (IL)-1beta (show IL1B Antibodies) release under inflammatory challenge.
development of allergic rhinitis proceeded in two distinct stages: histamine release from FcepsilonRI (show FCER1A Antibodies)-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity and activation through FcepsilonRI (show FCER1A Antibodies).
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.
G-protein coupled receptor 105
, histamine H4 receptor
, histamine receptor H4
, histamine 4 receptor
, histamine H4 receptor-like