anti-Histamine Receptor H4 (HRH4) Antibodies

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Additionally we are shipping Histamine Receptor H4 Kits (28) and Histamine Receptor H4 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HRH4 59340 Q9H3N8
HRH4 170704 Q91ZY1
HRH4 225192 Q91ZY2
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Top anti-Histamine Receptor H4 Antibodies at antibodies-online.com

Showing 10 out of 96 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-HRH4 Antibody Titration: 1.0 ug/ml Positive Control: 721_B Whole Cell HRH4 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IHC, IHC (p) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of LOVO cells, using HRH4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB WB Image Histamine H4 Receptor antibody detects Histamine H4 Receptor protein by western blot analysis. A. 30 μg Jurkat whole cell lysate/extract B. 30 μg Raji whole cell lysate/extract C. 30 μg NCI-H929 whole cell lysate/extract 10 % SDS-PAGE Histamine H4 Receptor antibody , dilution: 1:500 WB Image Histamine H4 Receptor antibody detects Histamine H4 Receptor protein by western blot analysis. A. 30 μg HeLa whole cell lysate/extract B. 30 μg whole cell lysate/extract of HRH4 shRNA-transfected HeLa cells 10 % SDS-PAGE Histamine H4 Receptor antibody , dilution: 1:500 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, IF, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-HRH4 / Histamine H4 Receptor antibody  ABIN1048963 IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-HRH4 / Histamine H4 Receptor antibody  ABIN1048966 IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Anti-HRH4 / Histamine H4 Receptor antibody  ABIN1048964 IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Ovary, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: Histamine H4 R Antibody [NLS3775] - IHC analysis of Lymph node using this antibody at 12 ug/ ml. Immunohistochemistry-Paraffin: Histamine H4 R Antibody  - Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Ovary, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 0.05 mL Log in to see 10 to 13 Days
$516.98
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details

More Antibodies against Histamine Receptor H4 Interaction Partners

Human Histamine Receptor H4 (HRH4) interaction partners

  1. these findings reveal that rs11662595 is a loss-of-function polymorphism that results in dysfunction of HRH4 and attenuates the anti-epithelial-to-mesenchymal transition function of HRH4 in non-small cell lung cancer (NSCLC), which provides a promising biomarker for prognosis and therapy of NSCLC.

  2. Taken together, the silencing of H4R inhibited the H4R mediated Mast cell functions and SAPK/JNK phosphorylation. Furthermore, the H4R activation utilized SAPK/JNK signaling pathway for IL-1beta release in HMC-1 cells

  3. Our novel scientific data provide further indication that histamine, in particular via the H4R, plays a potent role in the pathophysiology of allergic diseases through tight control of Th1-Th2 mediator production favoring Th2 lymphocyte accumulation in inflamed tissues. Our results add to a growing evidence of data suggesting that the H4R may serve as a therapeutic target in allergic diseases.

  4. The expression of H4R was increased in peripheral blood monocytes in rheumatoid arthritis patients. Histamine and Th17 cytokines induced the osteoclast differentiation from monocytes and JNJ7777120 decreased the osteoclastogenesis.

  5. H1R and H4R are useful biomarkers of allergic inflammation on the ocular surface. Most notably, H4R expressed on eosinophils is useful as a biomarker of eosinophilic inflammation of the ocular surface.

  6. Histamine stimulation influences the IL-17 pathway in psoriasis via the fourth histamine receptor subtype, H4R, on CD4+ T cells.

  7. This study suggests that genetic variations within the HRH4 gene might be associated with special clinical features of psoriasis.

  8. Our findings provide evidence that HRH4 rs77485247 and rs77041280 polymorphisms may be associated with the risk of allergic rhinitis (AR) and the efficacy of H1 antihistamines for the treatment of AR patients.

  9. These data imply that the H4R regulates IgE-dependent processes in human basophils and provides a novel function of the H4R preventing an overwhelming immune reaction by engagement of a negative feedback loop.

  10. Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells

  11. Histamine H4 receptors could not be identified in five experimental models of the guinea-pig that are suited for the detection of presynaptic inhibitory receptors (hippocampus aorta, atrium, renal cortex and vas deferens) whereas H3 receptors could be shown in the peripheral tissues but not in the hippocampus

  12. Taken together these data demonstrate that compound A and compound L may block H4R-mediated downstream signaling events.

  13. We also found that the activation of H4R caused the release of IL-13 and RANTES on human mast cells.these data demonstrate that the H4R activates divergent signaling pathways to induce cytokine and chemokine production in human mast cells

  14. H4R may be involved in the maintenance of healthy oral mucosa. In oral lichen planus, this maintenance might be impaired by mast cell degranulation and inflammatory cytokines.

  15. Activation of the H4R could induce phosphorylation of ERK.

  16. Suggest roles for HRH4 polymorphisms and ankylosing spondylitis susceptibility.

  17. H4 receptor expression plays a role in pathological vessel leakage associated with choroidal neovascularization

  18. Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R and hH4R, were studied.

  19. Functional H4 receptors increasing (35)S-GTPgammaS binding and/or decreasing noradrenaline release are not found in human, guinea pig or mouse cortex

  20. HRH4 was increased in clinically-isolated syndrome and different stages of multiple sclerosis compared to health control.

Mouse (Murine) Histamine Receptor H4 (HRH4) interaction partners

  1. colonic mast cells-derived histamine initiates granulocyte infiltration into the colonic mucosa through H4R

  2. This study demonstrated that the phenotype of H4R(-)/(-) mice leads to increased neuropathic pain hypersensitivity promoting an overactivation of spinal ERK-CREB pathway in DbetaH expressing neurons without modifying the innervation of the hind paw skin and integrity of the primary sensory neurons.

  3. H4R ligands have a beneficial effect in a model of lung fibrosis in the mouse, thus indicating that H4R antagonists or inverse agonists could be a novel therapeutic strategy for lung inflammatory diseases.

  4. Results illustrate that histamine H4 receptors (H4R) modulates various neurophysiological functions such as locomotor activity, anxiety, nociception and feeding behaviour, confirming the importance of the integrity and functionality of neuronal H4R in the histaminergic regulation of neuronal functions.

  5. These results identify the H4R as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation. These results further suggest that blocking the H4R in the skin might be beneficial in diseases like atopic dermatitis.

  6. Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis

  7. H4 receptor expression plays a role in pathological vessel leakage associated with choroidal neovascularization

  8. These results indicate a proinflammatory role of histamine via H4R in inflammatory bowel disease.

  9. Functional H4 receptors increasing (35)S-GTPgammaS binding and/or decreasing noradrenaline release are not found in human, guinea pig or mouse cortex

  10. in experimental asthma in mice the H4 receptor specifically regulates activation of dendritic cells during sensitization, while in the effector phase the H4 receptor is active in cells involved in the activation of eosinophils, and possibly other cells.

  11. involved in the pathogenesis and progression of rheumatoid arthritis

  12. These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation.

  13. the role of H4 receptors in immune disease is context-specific, depending on the animal model used and the complement of H4 receptor-expressing cells; H4 receptor blockade was detrimental in experimental autoimmune encephalomyelitis

  14. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.

  15. H4R expression on murine keratinocytes was detected after stimulation with LPS and peptidoglycan.

  16. HR4 is most important for the development of rheumatoid arthritis.

  17. the present study shows that H4 receptors potentially play a role in IgE induced FcepsilonRI upregulation

  18. Acting via its H4 receptors, histamine impedes lipopolysaccharide-induced microglia migration and interleukin (IL)-1beta release under inflammatory challenge.

  19. development of allergic rhinitis proceeded in two distinct stages: histamine release from FcepsilonRI-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity and activation through FcepsilonRI.

  20. analysis of fragment optimization and analysis of binding kinetics for ligand based design of novel histamine H receptor antagonists

Guinea Pig Histamine Receptor H4 (HRH4) interaction partners

  1. Functional H4 receptors increasing (35)S-GTPgammaS binding and/or decreasing noradrenaline release are not found in human, guinea pig or mouse cortex

Histamine Receptor H4 (HRH4) Antigen Profile

Protein Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HRH4

  • histamine receptor H4 (HRH4) antibody
  • histamine receptor H4 (Hrh4) antibody
  • AXOR35 antibody
  • BG26 antibody
  • GPCR105 antibody
  • GPRv53 antibody
  • H4 antibody
  • H4R antibody
  • HH4R antibody
  • HRH4 antibody

Protein level used designations for HRH4

G-protein coupled receptor 105 , SP9144 , histamine H4 receptor , pfi-013 , H4R , HH4R , histamine receptor H4 , histamine 4 receptor , histamine H4 receptor-like

GENE ID SPECIES
59340 Homo sapiens
170704 Rattus norvegicus
225192 Mus musculus
397224 Sus scrofa
468501 Pan troglodytes
490512 Canis lupus familiaris
702044 Macaca mulatta
769106 Gallus gallus
783354 Bos taurus
100034111 Equus caballus
100358525 Oryctolagus cuniculus
100379272 Cavia porcellus
100442858 Pongo abelii
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