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Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Additionally we are shipping Histamine Receptor H4 Kits (28) and Histamine Receptor H4 Proteins (9) and many more products for this protein.
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Our novel scientific data provide further indication that histamine, in particular via the H4R, plays a potent role in the pathophysiology of allergic diseases through tight control of Th1 (show TH1L Antibodies)-Th2 mediator production favoring Th2 lymphocyte accumulation in inflamed tissues. Our results add to a growing evidence of data suggesting that the H4R may serve as a therapeutic target in allergic diseases.
The expression of H4R was increased in peripheral blood monocytes in rheumatoid arthritis patients. Histamine and Th17 cytokines induced the osteoclast differentiation from monocytes and JNJ7777120 decreased the osteoclastogenesis.
H1R (show HRH1 Antibodies) and H4R are useful biomarkers of allergic inflammation on the ocular surface. Most notably, H4R expressed on eosinophils is useful as a biomarker of eosinophilic inflammation of the ocular surface.
Histamine stimulation influences the IL-17 (show IL17A Antibodies) pathway in psoriasis via the fourth histamine receptor subtype, H4R, on CD4 (show CD4 Antibodies)+ T cells.
This study suggests that genetic variations within the HRH4 gene might be associated with special clinical features of psoriasis.
Our findings provide evidence that HRH4 rs77485247 and rs77041280 polymorphisms may be associated with the risk of allergic rhinitis (AR) and the efficacy of H1 antihistamines for the treatment of AR patients.
These data imply that the H4R regulates IgE-dependent processes in human basophils and provides a novel function of the H4R preventing an overwhelming immune reaction by engagement of a negative feedback loop.
Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells
Histamine H4 receptors could not be identified in five experimental models of the guinea-pig that are suited for the detection of presynaptic inhibitory receptors (hippocampus aorta, atrium, renal cortex and vas (show AVP Antibodies) deferens) whereas H3 receptors could be shown in the peripheral tissues but not in the hippocampus
Taken together these data demonstrate that compound A and compound L may block H4R-mediated downstream signaling events.
This study demonstrated that the phenotype of H4R(-)/(-) mice leads to increased neuropathic pain hypersensitivity promoting an overactivation of spinal ERK (show EPHB2 Antibodies)-CREB (show CREB1 Antibodies) pathway in DbetaH expressing neurons without modifying the innervation of the hind paw skin and integrity of the primary sensory neurons.
H4R ligands have a beneficial effect in a model of lung fibrosis in the mouse, thus indicating that H4R antagonists or inverse agonists could be a novel therapeutic strategy for lung inflammatory diseases.
Results illustrate that histamine H4 receptors (H4R) modulates various neurophysiological functions such as locomotor activity, anxiety, nociception and feeding behaviour, confirming the importance of the integrity and functionality of neuronal H4R in the histaminergic regulation of neuronal functions.
These results identify the H4R as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation. These results further suggest that blocking the H4R in the skin might be beneficial in diseases like atopic dermatitis.
Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis
These results indicate a proinflammatory role of histamine via H4R in inflammatory bowel disease.
The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.
H4R expression on murine keratinocytes was detected after stimulation with LPS (show TLR4 Antibodies) and peptidoglycan.
the present study shows that H4 receptors potentially play a role in IgE induced FcepsilonRI (show FCER1A Antibodies) upregulation
Acting via its H4 receptors, histamine impedes lipopolysaccharide-induced microglia migration and interleukin (IL)-1beta (show IL1B Antibodies) release under inflammatory challenge.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.
G-protein coupled receptor 105
, histamine H4 receptor
, histamine receptor H4
, histamine 4 receptor
, histamine H4 receptor-like