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Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Histidine Triad Nucleotide Binding Protein 2 Antibodies (33) and Histidine Triad Nucleotide Binding Protein 2 Kits (6) and many more products for this protein.
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findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins.
Authors deduced that HINT2 triggers apoptosis in pancreatic cancer cells by regulating mitochondrial Ca(2+) influx through the mitochondrial calcium uniporter (MCU). Authors found that HINT2 can sensitize BxPC-3 and L3.6pl cells to gemcitabine-induced apoptosis and that gemcitabine up-regulates HINT2 expression.
HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1). These results suggest that HINT2 downregulation promotes HIF-2alpha expression, which induces EMT and enhances CRC cell migration and invasion.
Low HINT2 expression is associated with low response to therapy in endometrial cancer.
X-ray crystal structure of human HINT2 with and without bound AMP.
Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria.
Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002
histidine triad nucleotide binding protein 2
, histidine triad nucleotide-binding protein
, histidine triad nucleotide-binding protein 2, mitochondrial
, PKCI-1-related HIT protein
, protein kinase C inhibitor-2