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Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Histidine Triad Nucleotide Binding Protein 2 Antibodies (34) and Histidine Triad Nucleotide Binding Protein 2 Kits (6) and many more products for this protein.
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findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (show NCS1 Proteins) in mitochondrial function via its association with several mitochondrial proteins.
Authors deduced that HINT2 triggers apoptosis in pancreatic cancer cells by regulating mitochondrial Ca(2 (show CA2 Proteins)+) influx through the mitochondrial calcium uniporter (MCU (show MCU Proteins)). Authors found that HINT2 can sensitize BxPC-3 and L3.6pl cells to gemcitabine-induced apoptosis and that gemcitabine up-regulates HINT2 expression.
HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1). These results suggest that HINT2 downregulation promotes HIF-2alpha expression, which induces EMT and enhances CRC cell migration and invasion.
Low HINT2 expression is associated with low response to therapy in endometrial cancer.
X-ray crystal structure of human HINT2 with and without bound AMP (show APRT Proteins).
Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria.
The absence of Hint2 deregulates the posttranslational modification of several mitochondrial proteins, which impedes the adaptation to episodes of nutritional stress.
the effect of the mitochondrial protein (show COX6B2 Proteins) Hint2 on intracellular Ca(2 (show CA2 Proteins)+) dynamics
Hint2/HINT2 positively regulates mitochondrial lipid metabolism and respiration and glucose homeostasis.
Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002
histidine triad nucleotide binding protein 2
, histidine triad nucleotide-binding protein
, histidine triad nucleotide-binding protein 2, mitochondrial
, PKCI-1-related HIT protein
, protein kinase C inhibitor-2