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putative G-protein coupled receptor for nicotinic acid. Additionally we are shipping HCAR2 Antibodies (37) and and many more products for this protein.
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GPR109A may inhibit inflammatory cytokine production, induced by palmitic acid, by MIN6 cells possibly via inhibiting the Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signaling pathway.
These results demonstrate that GPR109A is functionally expressed in both human and murine islet beta-cells.
new insights into the G protein coupling profiles of the HCA receptors and the function of the receptor's C terminus
These results suggest that the PKC pathway and PDGFR (show PDGFRB ELISA Kits)/EGFR (show EGFR ELISA Kits) transactivation pathway play important roles in HCA2 (show ADCY10 ELISA Kits)-mediated Akt (show AKT1 ELISA Kits) activation.
Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys (show DNAJC5 ELISA Kits)(18)-Cys (show DNAJC5 ELISA Kits)(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.
niacin, at a relatively low concentration, preserves the ability of HMVEC to form tubes under conditions of saturated fatty acid excess, and may elicit this effect through activation of GPR109A
GPR109A expression is upregulated in blood and substantia nigra in Parkinson disease patients.
The results of this study suggested that GPR109A signaling is associated with T2DM, playing a role in regulation of the inflammatory cytokines.
the promiscuous activity exerted by niacin via both GPR109A and GPER (show GPER ELISA Kits) may open new avenues towards a better understanding of the mechanisms involved in its biological action exerted in different pathophysiological conditions, including malignant diseases.
Although its functional role is still unknown, HCA2 may be potentially involved in the pathogenesis of various retinopathies and may offer a new therapeutic target.
HCA2 plays a critical role in host protection against pro-inflammatory insults.
This study showed that the hypophagia of heat stress is independent of GPR109a, the hepatic vagus afferent nerve, and hepatic ketone body synthesis.
Enhanced GPR109a expression in jejunal enterocytes of T2DM mice suggests that GPR109a is involved in elevating intestinal glucose transport observed in diabetes.
The expression of GPR109A in pancreatic beta cells is not only influenced by inflammation and glucose, but also plays a protective role under inflammatory conditions.
These results suggest that the PKC (show PKC ELISA Kits) pathway and PDGFR (show PDGFRB ELISA Kits)/EGFR (show EGFR ELISA Kits) transactivation pathway play important roles in HCA2-mediated Akt (show AKT1 ELISA Kits) activation.
Data indicate that GPR109a modulates niacin-induced pancreatic islet dysfunction through activation of the islet beta-cells.
Data suggest that expression of Gpr109a is upregulated in adipocytes (intra-abdominal adipose tissue) and macrophages (peritoneal macrophages) during inflammation (models of gram-positive, gram-negative, viral, and fungal infections).
HCAR2 activation by dietary or pharmacological means instructs Ly-6C(Lo) monocytes and/or macrophages to deliver a neuroprotective signal to the brain.
GPR109A is a tumor suppressor in mammary gland.
putative G-protein coupled receptor for nicotinic acid
G protein-coupled receptor 109A
, G protein-coupled receptor HM74a
, G-protein coupled receptor 109A
, G-protein coupled receptor HM74A
, hydroxy-carboxylic acid receptor 2
, niacin receptor 1
, nicotinic acid receptor
, G protein-coupled receptor 109B
, G-protein coupled receptor 109
, G-protein coupled receptor HM74
, hydroxycarboxylic acid receptor 2
, interferon-gamma inducible gene, Puma-g
, putative seven transmembrane spanning receptor
, G protein-coupled receptor Hm74b
, protein PUMA-G