Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kits

putative G-protein coupled receptor for nicotinic acid. Additionally we are shipping HCAR2 Antibodies (55) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HCAR2 338442 Q8TDS4
Anti-Mouse HCAR2 HCAR2 80885 Q9EP66
HCAR2    
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Top HCAR2 ELISA Kits at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Rat < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details

More ELISA Kits for HCAR2 Interaction Partners

Human Hydroxycarboxylic Acid Receptor 2 (HCAR2) interaction partners

  1. GPR109A may inhibit inflammatory cytokine production, induced by palmitic acid, by MIN6 cells possibly via inhibiting the Akt/mTOR signaling pathway.

  2. These results demonstrate that GPR109A is functionally expressed in both human and murine islet beta-cells.

  3. new insights into the G protein coupling profiles of the HCA receptors and the function of the receptor's C terminus

  4. These results suggest that the PKC pathway and PDGFR/EGFR transactivation pathway play important roles in HCA2-mediated Akt activation.

  5. Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.

  6. niacin, at a relatively low concentration, preserves the ability of HMVEC to form tubes under conditions of saturated fatty acid excess, and may elicit this effect through activation of GPR109A

  7. GPR109A expression is upregulated in blood and substantia nigra in Parkinson disease patients.

  8. The results of this study suggested that GPR109A signaling is associated with T2DM, playing a role in regulation of the inflammatory cytokines.

  9. the promiscuous activity exerted by niacin via both GPR109A and GPER may open new avenues towards a better understanding of the mechanisms involved in its biological action exerted in different pathophysiological conditions, including malignant diseases.

  10. Although its functional role is still unknown, HCA2 may be potentially involved in the pathogenesis of various retinopathies and may offer a new therapeutic target.

  11. GPR109A is a tumor suppressor in mammary gland.

  12. These studies provide key insights into mechanisms by which GPR109A may influence cholesterol efflux in macrophages.

  13. despite NA's anti-inflammatory effect on human macrophages, it has no effect on foam cells in reverse cholesterol transport; due to GPR109A down-regulation

  14. Review of the role of GPR109A and its downstream effects in the context of atherosclerosis and vascular inflammation, along with insights into strategy for future drug development. [Review Article]

  15. A sequence from residues 329 to 343 in the C-terminal tail of HCA plays a crucial role in keeping HCA in an inactive conformation.

  16. Nicotnic acid displays a range of effects that are lipoprotein-independent and potentially antiatherogenic. These effects are mediated by GPR109A.

  17. upon binding to niacin GPR109A receptors initially activate G(i), leading to dissociation of the Gbetagamma subunit from activated G(i), and subsequently induce ERK1/2 activation via two distinct pathways.

  18. In contrast, in a squamous cell carcinoma derived cell line, both GPR109A and GPR109B show a more diffuse cellular localization and the receptors are nearly non-functional.

  19. niacin-mediated activation of GP109A in liver lowers ABCA1 expression leading to reduced hepatic cholesterol efflux to high density lipoprotein.

  20. The agonist-induced internalization of GPR109A receptors is regulated by GRK2 and arrestin3 in a pertussis toxin-sensitive manner and that internalized receptor recycling is independent of endosomal acidification.

HCAR2 Antigen Profile

Antigen Summary

putative G-protein coupled receptor for nicotinic acid

Gene names and symbols associated with HCAR2

  • hydroxycarboxylic acid receptor 2 (HCAR2) antibody
  • hydroxycarboxylic acid receptor 2 (Hcar2) antibody
  • hydroxycarboxylic acid receptor 2 (LOC527744) antibody
  • Gpr109a antibody
  • Gpr109b antibody
  • HCA2 antibody
  • HCAR2 antibody
  • HCAR3 antibody
  • HM74 antibody
  • HM74a antibody
  • HM74b antibody
  • mHM74b antibody
  • NIACR1 antibody
  • PUMA-G antibody
  • Pumag antibody

Protein level used designations for HCAR2

G protein-coupled receptor 109A , G protein-coupled receptor HM74a , G-protein coupled receptor 109A , G-protein coupled receptor HM74A , hydroxy-carboxylic acid receptor 2 , niacin receptor 1 , nicotinic acid receptor , G protein-coupled receptor 109B , G-protein coupled receptor 109 , G-protein coupled receptor HM74 , hydroxycarboxylic acid receptor 2 , interferon-gamma inducible gene, Puma-g , putative seven transmembrane spanning receptor , hydroxycarboxylic acid receptor 3

GENE ID SPECIES
338442 Homo sapiens
80885 Mus musculus
527744 Bos taurus
100346068 Oryctolagus cuniculus
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