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The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Additionally we are shipping ICT1 Antibodies (64) and ICT1 Proteins (10) and many more products for this protein.
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our preliminary study reveals the important role of ICT1 in NSCLC cells that knockdown of ICT1 significantly suppressed cell proliferation, arrested cell cycle though altering expression cell cycle regulators, and promoted cell apoptosis.
ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK/JNK (show MAPK8 ELISA Kits), and PARP (show COL11A2 ELISA Kits) signaling pathways.
ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells.
ICT1 knockdown altered the expression of apoptosis- or cell cyclerelated proteins such as Bcl-2 (show BCL2 ELISA Kits), caspase-3 (show CASP3 ELISA Kits), CDK1 (show CDK1 ELISA Kits), CDK2 (show CDK2 ELISA Kits) and cyclin B.
ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes.
Because ICT1 is essential in human cells, these results suggest that ribosome rescue activity in mitochondria is required in humans
solution structure of the catalytic domain of the ICT1 protein that lacks an N-terminal mitochondrial targeting signal and an unstructured C-terminal basic-residue-rich extension
The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. One potential marker is ICT1 whose mRNA and protein were more highly expressed in undifferentiated than in differentiated cells.
immature colon carcinoma transcript 1
, Immature colon carcinoma transcript 1
, Immature colon carcinoma transcript 1 protein homolog
, Peptidyl-tRNA hydrolase ICT1, mitochondrial
, digestion substraction 1
, immature colon carcinoma transcript 1 protein
, peptidyl-tRNA hydrolase ICT1, mitochondrial
, immature colon carcinoma transcript 1 protein homolog