Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein Proteins (ID4)

ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Additionally we are shipping ID4 Antibodies (86) and ID4 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ID4 15904 P41139
Rat ID4 ID4 291023  
ID4 3400 P47928
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Top ID4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,271.50
Details

ID4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) Interaction Partners

Mouse (Murine) Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states

  2. results indicate that Id4 marks spermatogonial stem cells in the mouse testis.

  3. ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.

  4. Id4 regulates NKX3.1, Sox9 and PTEN.

  5. Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (show ESR1 Proteins) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary

  6. High expression levels of Id1 (show ID1 Proteins)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.

  7. CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 (show PRMT5 Proteins) and were hypomethylated in PRMT5 (show PRMT5 Proteins)-deficient cells, suggesting that PRMT5 (show PRMT5 Proteins) plays a role in gene silencing during glial cell

  8. ID4 promotes mammary gland development by suppressing p38MAPK (show MAPK14 Proteins) activity.

  9. Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.

  10. Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.

Zebrafish Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (show WNT2 Proteins) signaling in the developing AVC endocardium

Human Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. These findings indicate that ID4 acts as a tumour suppressor in myeloid malignancies, and ID4 methylation is a potential biomarker in predicting disease progression and treatment outcome.

  2. results highlight a key role for MALAT1 in control of VEGFA (show VEGFA Proteins) isoforms expression in breast cancer cells expressing gain-of-function mutant p53 (show TP53 Proteins) and ID4 proteins.

  3. Study demonstrates that ID4, can promote p53 (show TP53 Proteins)- dependent apoptosis and senescence in prostate cancer cells by specifically modifying the acetylation of p53 (show TP53 Proteins), which increases its transcriptional activity and promotes the expression of pro-apoptotic and cell cycle regulatory genes.

  4. The cellular uptake of inhibitor of DNA binding 4 protein (ID4) resulted in increased apoptosis, decreased proliferation and colony formation.

  5. Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.

  6. The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients, and overexpression of Id4 promoted HCC (show FAM126A Proteins) cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.

  7. ID4 selectively regulates AR activity through direct interaction with FKBP52 (show FKBP4 Proteins).

  8. High ID4 expression is associated with basal breast cancer.

  9. A cell-autonomous positive-signaling circuit is associated with the PDGFB (show PDGFB Proteins)-NO-ID4-regulatory axis in glioblastoma cells.

  10. ID4 expression induces AR expression in PC3 (show PCSK1 Proteins) cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.

ID4 Protein Profile

Protein Summary

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.

Gene names and symbols associated with ID4

  • inhibitor of DNA binding 4 (Id4)
  • inhibitor of DNA binding 4, HLH protein (Id4)
  • inhibitor of DNA binding 4 (id4)
  • inhibitor of DNA binding 4, HLH protein S homeolog (id4.S)
  • inhibitor of DNA binding 4, HLH protein (ID4)
  • bhlhb27 protein
  • cb547 protein
  • fb77d04 protein
  • id4 protein
  • id4a protein
  • IDB4 protein
  • sb:cb547 protein
  • wu:fb77d04 protein
  • zgc:123214 protein

Protein level used designations for ID4

DNA-binding protein inhibitor ID-4 , inhibitor of DNA binding 4 a , class B basic helix-loop-helix protein 27

GENE ID SPECIES
15904 Mus musculus
291023 Rattus norvegicus
664761 Danio rerio
380396 Xenopus laevis
374150 Gallus gallus
3400 Homo sapiens
610666 Canis lupus familiaris
100144508 Sus scrofa
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