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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Additionally we are shipping ID4 Antibodies (79) and ID4 Kits (3) and many more products for this protein.
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ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states
results indicate that Id4 marks spermatogonial stem cells in the mouse testis.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1, Sox9 and PTEN.
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (show ESR1 Proteins) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (show ID1 Proteins)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 (show PRMT5 Proteins) and were hypomethylated in PRMT5 (show PRMT5 Proteins)-deficient cells, suggesting that PRMT5 (show PRMT5 Proteins) plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (show MAPK14 Proteins) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (show WNT2 Proteins) signaling in the developing AVC endocardium
Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.
The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients, and overexpression of Id4 promoted HCC (show FAM126A Proteins) cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.
ID4 selectively regulates AR activity through direct interaction with FKBP52 (show FKBP4 Proteins).
High ID4 expression is associated with basal breast cancer.
A cell-autonomous positive-signaling circuit is associated with the PDGFB (show PDGFB Proteins)-NO-ID4-regulatory axis in glioblastoma cells.
ID4 expression induces AR expression in PC3 (show PCSK1 Proteins) cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.
CEACAM1 (show CEACAM1 Proteins) is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 (show HDAC4 Proteins) and CaMK2D (show CAMK2D Proteins), and the same kinase enables lumen formation by CEACAM1 (show CEACAM1 Proteins)
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (show NR4A2 Proteins))early growth response (EGR)2 (show EGR2 Proteins) and NR4A2EGR3. Therefore, RUNX1 (show RUNX1 Proteins), NR4A2 (show NR4A2 Proteins), EGR2 (show EGR2 Proteins), EGR3 (show EGR3 Proteins) and ID4 may be key genes associated with the pathogenesis of DS.
changes in gene amplification in the mitochondrial genome and in the ID4 gene promoter methylation region in patients with chronic aplastic anemia (CAA) suffering from Kidney (Shen) yin deficiency or Kidney yang deficiency, were analyzed.
Hypermethylation of ID4 promotes the proliferation of Burkitt's lymphoma cells; ID4 may function as a tumor suppressor and can be targeted with demethylating compounds such as CdR (show RUNX1T1 Proteins) for the treatment of Burkitt's lymphoma
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27