Inositol-Tetrakisphosphate 1-Kinase Proteins (ITPK1)

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.

list all proteins Gene Name GeneID UniProt
Human ITPK1 ITPK1 3705 Q13572
Mouse ITPK1 ITPK1 217837 Q8BYN3
Rat ITPK1 ITPK1 500709  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top ITPK1 Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$492.31
Details
Yeast REACT_Entamoeba histolytica His tag   1 mg Log in to see 60 to 71 Days
$2,856.33
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$3,094.67
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,129.50
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,166.17
Details

More Proteins for Inositol-Tetrakisphosphate 1-Kinase (ITPK1) Interaction Partners

Human Inositol-Tetrakisphosphate 1-Kinase (ITPK1) interaction partners

  1. The results suggested that the maternal rs3783903 of ITPK1 might be associated with spina bifida, and the allele G of rs3783903 might affect the binding of AP-1 (show FOSB Proteins) and the decrease of maternal plasma inositol hexakisphosphate concentration.

  2. Activation of PLC (show HSPG2 Proteins) by an endogenous cytokine (GBP (show HADHA Proteins)) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.

  3. HEK293 cells stably expressing acetylated ITPK1 had reduced levels of the higher phosphorylated forms of inositol, compared with the levels seen in cells expressing unacetylated ITPK1

  4. 5/6-kinase modifies TNFalpha (show TNF Proteins)-induced apoptosis by interfering with the activation of TNF-R1 (show TNFRSF1A Proteins)-associated death domain

  5. analysis of inositol phosphate signaling pathway integration via human ITPK1

Mouse (Murine) Inositol-Tetrakisphosphate 1-Kinase (ITPK1) interaction partners

  1. Data suggest that relative deficiency of one or more inositol phosphates accounts for neural tube defects in inositol 1,3,4-trisphosphate 5/6-kinase knockout mice.

  2. Apical localization of Itpk1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis (show S100A8 Proteins).

ITPK1 Protein Profile

Protein Summary

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway.

Gene names and symbols associated with ITPK1

  • inositol-tetrakisphosphate 1-kinase (ITPK1)
  • inositol 1,3,4-triphosphate 5/6 kinase (Itpk1)
  • inositol-tetrakisphosphate 1-kinase L homeolog (itpk1.L)
  • inositol-tetrakisphosphate 1-kinase a (itpk1a)
  • inositol-tetrakisphosphate 1-kinase (Itpk1)
  • BC031182 protein
  • ITRPK1 protein
  • wu:fj15d08 protein
  • zgc:56075 protein

Protein level used designations for ITPK1

inositol 1,3,4-triphosphate 5/6 kinase , inositol 1,3,4-trisphosphate 5/6 kinase , inositol 1,3,4-trisphosphate 5/6-kinase , inositol-triphosphate 5/6-kinase , ins(1,3,4)P(3) 5/6-kinase , inositol-tetrakisphosphate 1-kinase

GENE ID SPECIES
3705 Homo sapiens
217837 Mus musculus
379828 Xenopus laevis
406290 Danio rerio
423421 Gallus gallus
500709 Rattus norvegicus
518488 Bos taurus
100152339 Sus scrofa
100717610 Cavia porcellus
Did you look for something else?