Inositol-Trisphosphate 3-Kinase B Proteins (ITPKB)

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. Additionally we are shipping ITPKB Antibodies (54) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse ITPKB ITPKB 320404  
ITPKB 3707 P27987
Rat ITPKB ITPKB 54260 P42335
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Top ITPKB Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Log in to see 11 Days

ITPKB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Inositol-Trisphosphate 3-Kinase B (ITPKB) Interaction Partners

Mouse (Murine) Inositol-Trisphosphate 3-Kinase B (ITPKB) interaction partners

  1. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb restricts pre-T cell receptor (show PTCRA Proteins) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (show PTCRA Proteins) expression and Notch (show NOTCH1 Proteins)-engagement.

  2. These data identify Itpkb as an essential mediator of T cell activation and suggest Itpkb inhibition as a novel approach to treat autoimmune disease.

  3. Itpkb controls hematopoietic stem cell homeostasis and prevent death from severe anemia in mice.

  4. Itpkb controls survival, proliferation and cytokine production in mouse peripheral T cells.

  5. Data present the structure of the complete catalytic domain of inositol 1,4,5-trisphophate 3-kinase B, including the CaM binding domain in complex with Mg(2 (show MCOLN1 Proteins)+) and ATP.

  6. These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6 (show GPRIN2 Proteins), at least in mouse embryonic fibroblasts.[Itpka (show ITPKA Proteins), Itpkb, Itpkc (show ITPKC Proteins)]

  7. Itpkb and inositol tetrakisphosphate mediate a survival signal in B cells.

  8. B cells from Itpkb(-/-) Ig hen (show RPS6 Proteins) egg lysozyme (show LYZ Proteins) mice possess an anergic phenotype, hypoproliferate in response to cognate Ag, and yet they exhibit enhanced Ag-induced calcium signaling

Human Inositol-Trisphosphate 3-Kinase B (ITPKB) interaction partners

  1. miR (show MLXIP Proteins)-140-5p regulates this context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (IP3k2). Therefore, the results of the present study demonstrated that miR (show MLXIP Proteins)-140-5p mediated drug-resistance in osteosarcoma cells by inducing autophagy.

  2. The authors confirm downregulation of miR (show MLXIP Proteins)-132 and upregulation of ITPKB in three distinct human Alzheimer's disease patient cohorts.

  3. ITPKB is increased in Alzheimer's brain three-fold in the cerebral cortex of most patients with Alzheimer's disease compared with control subjects and accumulates in dystrophic neurites associated with amyloid plaques.

  4. a specific increase in inositol 1,4,5-trisphosphate 3-kinase A (show ITPKA Proteins) and B (ITPKA (show ITPKA Proteins) and ITPKB) was observed upon hESCs spontaneous differentiation.

  5. IP3KB not only regulates cytoplasmic Ca(2 (show CA2 Proteins)+) signals by phosphorylation of subplasmalemmal and cytoplasmic Ins (show INS Proteins)(1,4,5)P(3) but may also be involved in modulating nuclear Ca(2 (show CA2 Proteins)+) signals generated from these nuclear envelope invaginations.

  6. results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2 (show CA2 Proteins)+ responses to extracellular signals

  7. We aim to summarize the existing information about functionally uncoupled IP(3)R (show ITPR1 Proteins) and RyR (show RYR1 Proteins) channels, and to discuss the concept that those channels can participate in Ca(2 (show CA2 Proteins)+)-leak pathways.

  8. In each of the three isoforms a nuclear export signal has evolved in the catalytic domain either de novo (IP3K-A (show ITPKA Proteins)) or as a substitute for an earlier evolved corresponding N-terminal signal (IP3K-B and IP3K-C (show ITPKC Proteins)).

ITPKB Protein Profile

Protein Summary

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.

Gene names and symbols associated with ITPKB

  • inositol 1,4,5-trisphosphate 3-kinase B (Itpkb)
  • inositol-trisphosphate 3-kinase B (ITPKB)
  • inositol-trisphosphate 3-kinase B (itpkb)
  • inositol-trisphosphate 3-kinase B (LOC698185)
  • inositol-trisphosphate 3-kinase B (Itpkb)
  • 1110033J02Rik protein
  • E130307H12Rik protein
  • IP3-3KB protein
  • IP3K protein
  • IP3K-B protein
  • IP3KB protein
  • PIG37 protein
  • si:ch211-97m8.1 protein

Protein level used designations for ITPKB

inositol-trisphosphate 3-kinase B , inositol 1,4,5-trisphosphate 3-kinase B , 1D-myo-inositol-trisphosphate 3-kinase B , inositol-trisphosphate 3-kinase B-like , IP3 3-kinase B , IP3K B , insP 3-kinase B , proliferation-inducing protein 37 , IP3K-B

320404 Mus musculus
416743 Gallus gallus
457789 Pan troglodytes
490383 Canis lupus familiaris
540877 Bos taurus
563019 Danio rerio
698185 Macaca mulatta
100400613 Callithrix jacchus
100460190 Pongo abelii
100603824 Nomascus leucogenys
3707 Homo sapiens
54260 Rattus norvegicus
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