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IFNGR2 (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Additionally we are shipping IFNGR2 Antibodies (121) and IFNGR2 Kits (4) and many more products for this protein.
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Myeloid cell IFNGR2 deficiency does not affect atherosclerosis development in LDLR (show LDLR Proteins) knockout mice.
A crystal structure of the extracellular part of human interferon-gamma receptor 2 (IFNGR2) was solved by molecular replacement at 1.8 A resolution.
Data suggest IFNG (show IFNG Proteins) plays various roles in dynamics of inflammation in subjects with underlying autoimmunity modeled as "canonical" and "non-canonical" pathways; in canonical pathway, IFNG (show IFNG Proteins) dimerizes and binds to IFNGR1 (show IFNGR1 Proteins) in IFNGR1 (show IFNGR1 Proteins)/IFNGR2 hetero-multimer; STAT (show STAT1 Proteins) transcription factors are involved in non-canonical pathway. (IFNG (show IFNG Proteins) = interferon gamma (show IFNG Proteins); IFNGR (show IFNGR1 Proteins) = IFNG (show IFNG Proteins) receptor; STAT (show STAT1 Proteins) = signal transducers and activators of transcription)
IFN-gammaR2 T168N mutant diffusion is confined by distinct actin nanodomains where conformational changes required for JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) activation by IFN-gamma (show IFNG Proteins) could not occur. Removing IFN-gammaR2 T168N-bound galectins restored lateral diffusion in lipid nanodomains and JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling in patient cells, whereas adding galectins impaired these processes in control cells.
Statistical analyses revealed that four genetic variants in IFNGR1 (show IFNGR1 Proteins) were marginally associated with the risk of Tuberculosis (P = 0.02-0.04), while other single nucleotide polymorphisms in IFNGR1 (show IFNGR1 Proteins) and IFNGR2 did not exhibit any associations
The variability of potentially important functional polymorphic variants of the IFNG (show IFNG Proteins), IFNGR2 and NEIL2 (show NEIL2 Proteins) genes was characterized in representatives of four ethnic groups living in the Siberian region.
Fatal hemophagocytic lymphohistiocytosis has been described in two unrelated pediatric patients with underlying IFNGR2 deficiency.
The expression of IFNGR2 was significantly higher in patients with RA compared with control subjects and was significantly higher in patients in whom radiographic damage was more severe.
We report a molecular study of the two known patients with autosomal recessive, partial interferon-gamma (show IFNG Proteins) receptor (IFN-gammaR (show IFNGR1 Proteins))2 deficiency
IFN-gammaR2-deficient monocytes induce a higher percentage of IL-17 (show IL17A Proteins)(+) cells from both healthy and IFN-gammaR2-deficient CD4 (show CD4 Proteins)(+) T cells.
IFNGR2 haploinsufficiency may underlie clinical tuberculosis in children living in areas of endemic disease.
Four SNPs in IFNGR2, IL12RB1 (show IL12RB1 Proteins), IL12RB2 (show IL12RB2 Proteins), and IL23R (show IL23R Proteins) were found to be associated with the MAP infection status of the resource population.
SNPs in IFNG (show IFNG Proteins), IFNGR1 (show IFNGR1 Proteins) and R2, IL22 (show IL22 Proteins), and IL22RA1 (show IL22RA1 Proteins) were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
IFN-gamma receptor 2
, interferon gamma receptor 2
, interferon gamma receptor accessory factor 1
, interferon gamma receptor accessory factor-1
, interferon gamma receptor beta chain
, interferon gamma transducer 1