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The protein encoded by IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. Additionally we are shipping IL18BP Antibodies (117) and IL18BP Proteins (28) and many more products for this protein.
Showing 5 out of 38 products:
Mouse (Murine) IL18BP ELISA Kit for Sandwich ELISA - ABIN430706
Hillestad, Espe, Cero, Larsen, Sjaastad, Nygård, Skjønsberg, Christensen: IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice. in Acta physiologica (Oxford, England) 2015
A full-length cDNA of the rhesus IL-18BP (RhIL-18BP) from the spleen of rhesus macaques, was cloned and sequenced.
Pressure overload, while enhancing IL-18 (show IL18 ELISA Kits) and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 (show IL18 ELISA Kits) antagonist IL-18BP.
IL-18BP ameliorates cardiac ischemia/reperfusion injury in part through suppression of Th17 differentiation.
Data show that IL-18bp acts as a sensor for IFN-gamma (show IFNG ELISA Kits) and can regulate both Th1 (show HAND1 ELISA Kits) and Th17 responses in the CNS.
Administratioan of murine IL-18BP at the time of the booster injection of bovine CII reduces the progressive severity of collagen-induced arthritis; both clinical disease activity and histological scores are decreased by 50%.
functional polarization of Ag-specific CD4 (show CD4 ELISA Kits)(+) Th2 cells entering the CNS during the accelerating phase of experimental autoimmune encephalomyelitis is flexible and dependent on IL-18 (show IL18 ELISA Kits), which is overturned by IL-18 (show IL18 ELISA Kits) binding protein
IL-18 (show IL18 ELISA Kits) and IL-18BP may have roles in testicular development, and also in the regulation of testicular functions under physiological conditions
A single intravenous dose of recombinant mouse IL18BP decreased neointimal hyperplasia and improved arterial L/A ratios in an atherosclerotic balloon-injury animal model.
these results were corroborated in female osteoporotic subjects where decreased serum IL-18BP levels and enhanced serum IL-18 (show IL18 ELISA Kits) levels were observed. Our study forms a strong basis for using humanized IL-18BP towards the treatment of postmenopausal osteoporosis.
epigenetic silencing by single CpG methylation determines differential IL18BP inducibility in monocytic versus epithelial cells. T
a large proportion blood basophils from patients with asthma express IL-18 (show IL18 ELISA Kits) and IL-18BP. mast cells and basophils are implicated in the pathogenesis of asthma via an IL-18 (show IL18 ELISA Kits)-related mechanism.
The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability ofLong Term Non-Progressors to delay AIDS progression.
Platelets also contain the IL-18 (show IL18 ELISA Kits) antagonist, the IL-18 (show IL18 ELISA Kits)-Binding Protein (IL-18BP); however, it is not synthesized in them de novo, is present in pre-made form and is released irrespective of platelet activation.
The serum levels of IL-37, which were correlated with antibody production and the serum levels of total IL-18 (show IL18 ELISA Kits) and IL-18BP, were elevated in the patients with primary Sjogren's syndrome.
an imbalance in the production of IL-18 (show IL18 ELISA Kits) and its antagonist (an increase in the production of IL-18 (show IL18 ELISA Kits) with a decrease, no increase or an insufficient increase in the production of IL-18BP) has been described in many chronic inflammatory diseases in humans.
IL-18 (show IL18 ELISA Kits), IL-18R and IL-18BP expression in eosinophil are involved in the inflammatory reaction of asthma.
the inhibition of IL-18 (show IL18 ELISA Kits) signaling by IL-18BPa may be involved in the development of pulmonary vascular involvement leading to pulmonary hypertension and modulate the systemic inflammation in systemic sclerosis
The natural IL-18 (show IL18 ELISA Kits) inhibitor IL-18BP further regulates IL-18 (show IL18 ELISA Kits) activity in the extracellular environment. Review.
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
interleukin 18 binding protein
, interferon gamma inducing factor binding protein
, interferon gamma-inducing factor-binding protein
, interleukin-18-binding protein
, MC51L-53L-54L homolog gene product
, interleukin-18 binding protein