Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) ELISA Kits

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH1 Antibodies (231) and IDH1 Proteins (17) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top IDH1 ELISA Kits at antibodies-online.com

Showing 7 out of 19 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.33 ng/mL 0.78 ng/mL - 50 ng/mL Typical standard curve 96 Tests 12 to 14 Days
$736.84
Details
Rat 1.35 ng/mL 3.12 ng/mL - 200 ng/mL 96 Tests 13 to 16 Days
$800.00
Details
Human 0.28 ng/mL 0.69 ng/mL - 500 ng/mL 96 Tests 13 to 16 Days
$884.21
Details
Rat < 1.35 ng/mL 3.12 ng/mL - 200 ng/mL   96 Tests 11 to 18 Days
$966.52
Details
Mouse
  96 Tests 11 to 18 Days
$618.29
Details
Cow
  96 Tests 15 to 18 Days
$1,029.60
Details
Pig
  96 Tests 15 to 18 Days
$1,029.60
Details

Top referenced IDH1 ELISA Kits

  1. Human IDH1 ELISA Kit for Sandwich ELISA - ABIN6574327 : Tan, Jiang, Sun, Chen, Lv, Shao, Li, Qiu, Gao, Li, Tan, Zhou, Wang, Ding, Wang, Sun, Hang, Shi, Feng, He, He: Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis. in Molecular & cellular proteomics : MCP 2012 (PubMed)
    Show all 4 Pubmed References

More ELISA Kits for IDH1 Interaction Partners

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. study provides useful resources of unconventional RBPs and IDH1-bound transcriptome, and convincingly illustrates, for the first time, the in vivo and in vitro RNA targets and binding preferences of IDH1, revealing an unanticipated complexity of RNA regulation in diverse cellular processes

  2. analysis of glioblastoma alterations such as IDH mutation, NF1 inactivation, and CDK4-MARCH9 locus amplification

  3. IDH1 mutation is associated with glioma.

  4. This study identified a seven-gene signature that can provide a more accurate predictor of 3 years and 5 years for patients with IDH-mutant glioma.

  5. IDH1/2(MUT) inhibitors protected against these treatments.

  6. Within IDH1-wildtype glioblastoma tumors, the subtypes revealed different survival (p < 0.001), thereby highlighting the synergistic consideration of molecular and imaging measures for prognostication.

  7. Results find the prevalence of the IDH1105GGT SNP considerably higher in patients with brain tumors compared to the control population. IDH1(105GGT) was more frequent in grade III tumors compared to grade II and grade IV. IDH1 (105GGT) was more frequent in grade II and III tumors without an IDH tumor missense mutation than in those with. The IDH1(105GGT) SNP likely represents an important genetic marker in brain tumors.

  8. Authors describe a biosynthetic pathway exhibited by cells expressing mutant IDH1. By virtue of a change in cellular redox homeostasis, IDH1-mutated cells synthesize excess glutamine-derived proline through enhanced activity of pyrroline 5-carboxylate reductase 1 (PYCR1), coupled to NADH oxidation.

  9. Although brain tumor patients with IDH1 mutation are at very low risk of venous thromboembolism, the risk of VTE in patients with IDH1 wild-type tumors is strongly linked to podoplanin expression levels.

  10. Detection of IDH1 and IDH2 Mutation in Formalin-fixed Paraffin-embedded Gliomas Using Allele-specific COLD-PCR and Probe Melting Curve Analysis.

  11. noninvasive determination of the IDH mutation status of a presumed glioma by means of MRS may be incorporated into a routine diagnostic imaging protocol and can be used to obtain additional information for patient care

  12. World Health Organization classification of brain tumors introduced isocitrate dehydrogenase genotype and epigenetic 1p/19q codeletion as two key molecular markers.

  13. IDH1 mutation is an independent factor for longer overall survival and progression free survival in glioblastoma multiforme patients when compared to wild-type IDH1 (review).

  14. IDH1-R132 changes are associated with NPM1 and other mutations status in acute myeloid leukemia.

  15. IDH1(R132C) mutation was relatively prevalent in intrahepatic cholangiocarcinoma; IDH1R132C mutation was involved with downregulated genes with hypermethylation status

  16. These results indicated that mutation of IDH1 aggravated the fatty acidinduced oxidative stress in HCT116 cells, by suppressing FAO and disrupting the mitochondrial respiratory chain. The results of the present study may provide novel insight into therapeutic strategies for the treatment of cancer types with IDH mutation.

  17. The overexpression of total and phosphorylated mTOR as well as phosphorylated rpS6 (residues 240-244) were associated with wild-type IDH1 only glioblastomas. The expression and phosphorylation of mTOR and phosphorylation of rpS6 at residues 240-244 were associated with a worse prognosis in glioblastomas.

  18. Fibulin-5 silencing in non-small-cell lung cancer cells is due to the hypermethylation of its promoter through 2-hydroxyglutarate, production of which arises from a mutation in IDH1.

  19. combined expression of Jak2V617F and mutant IDH1R132H or Idh2R140Q induces myeloproliferative neoplasm progression, alters stem/progenitor cell function, and impairs differentiation

  20. IDH1 mutation causing metabolic stress is associated with glioma.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. findings support the hypothesis that IDH1(R132H) promotes glioma development.

  2. combined expression of Jak2V617F and mutant IDH1R132H or Idh2R140Q induces myeloproliferative neoplasm progression, alters stem/progenitor cell function, and impairs differentiation

  3. Vitamin C treatment induced an IDH1(R132H)-dependent reduction in cell proliferation.

  4. IDH1 expression regulates TCA cycle in glioma and affects glioma cell growth.GDH2 promotes growth of IDH1-expressing gliomas.

  5. Through the use of a conditional mutant mouse model that confers a less aggressive tumor phenotype, findings provide new insight into the effects of mutant Idh1 on a candidate cell of origin for glioma, mutant Idh1's role in disrupting the microenvironment from which gliomas arise, and mutant Idh1's effect on the course of glioma progression.

  6. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system.

  7. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis

  8. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  9. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1, enzymes involved in the TCA cycle, were elevated.

  10. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  11. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  12. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  13. MiR-181a regulates lipid metabolism via IDH1

  14. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  15. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

  16. WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation.

  17. Brain-specific Idh1-KI mice show brain hemorrhage accompanied by high D2HG levels but decreased ROS

  18. Suggest that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes.

  19. Absence of IDH1 mutations in low-grade gliomas (LGGs) identifies a novel entity of LGGs with distinctive location, infiltrative behavior, specific molecular alterations, and dismal outcome.

  20. a possible association between IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Zebrafish Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. generated a transgenic zebrafish model system for mutations in IDH1 that can be used for functional analysis and drug screening. Our model systems help understand the biology of IDH1 mutations and its role in tumor formation.

IDH1 Antigen Profile

Antigen Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Gene names and symbols associated with IDH1

  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1) antibody
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1) antibody
  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic (Idh1) antibody
  • isocitrate dehydrogenase 1 (NADP+) L homeolog (idh1.L) antibody
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1) antibody
  • AI314845 antibody
  • AI788952 antibody
  • cb876 antibody
  • E030024J03Rik antibody
  • fm90e09 antibody
  • Id-1 antibody
  • IDCD antibody
  • IDH antibody
  • Idh-1 antibody
  • IDP antibody
  • Idpc antibody
  • im:7143416 antibody
  • NADP-CICDH antibody
  • PICD antibody
  • wu:fm90e09 antibody

Protein level used designations for IDH1

NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , Isocitrate dehydrogenase 1, soluble , isocitrate dehydrogenase 1

GENE ID SPECIES
3417 Homo sapiens
443257 Ovis aries
751618 Felis catus
100414768 Callithrix jacchus
15926 Mus musculus
24479 Rattus norvegicus
494713 Xenopus laevis
281235 Bos taurus
100328559 Oryctolagus cuniculus
478889 Canis lupus familiaris
100006589 Danio rerio
100729107 Cavia porcellus
100066416 Equus caballus
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