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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Antibodies (118) and IDH2 Proteins (20) and many more products for this protein.
Showing 5 out of 16 products:
Leaf IDH activity reduced by 43% in mutant
Identification of driver and subclonal mutations in ASXL1 and IDH1 (show IDH1 ELISA Kits)/IDH2 genes in an Argentine series of patients with myelofibrosis.
an overview of the biological and clinical implications of IDH1 (show IDH1 ELISA Kits) and IDH2 mutations in acute myeloid leukemia (show BCL11A ELISA Kits) (review).
genetic association studies in population in Czech Republic: Data suggest that mutations in IDH1 (show IDH1 ELISA Kits) and IDH2 are associated with AML (show RUNX1 ELISA Kits) (acute myeloid leukemia (show BCL11A ELISA Kits)); IDH1 (show IDH1 ELISA Kits)/2-based monitoring of MRD (minimal residual disease) appears to have prognostic value for residual disease in AML (show RUNX1 ELISA Kits) patients.
There was significant prognostic difference among the 4 glioma subtypes. Combined IDH (show IDH1 ELISA Kits) and TERT (show TERT ELISA Kits) gene mutation analysis may be useful for prognostic subgrouping. Notably, IDH1 (show IDH1 ELISA Kits) wild-type cases can be further subdivided into TERT (show TERT ELISA Kits)(+ ) or (-) subgroups with significant prognostic difference.
Generation of 2-hydroxyglutarate by mutated IDH1 (show IDH1 ELISA Kits)/2 leads to the activation of mTOR (show FRAP1 ELISA Kits) by inhibiting KDM4A (show KDM4A ELISA Kits).
Enasidenib reduces 2-hydroxyglutarate levels in patients with relapsed or refractory (R/R) acute myeloid leukemia (show BCL11A ELISA Kits) harboring either IDH2-R140 or IDH2-R172 mutations
IDH2 mutation is associated with glioma progression.
No correlation between IDH1 (show IDH1 ELISA Kits)/2 mutation status and sensitivity for NAMPT (show NAMPT ELISA Kits) inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT (show NAMPT ELISA Kits) as a potential target for treatment of chondrosarcoma
This study furthers implementation of clinical genomics in MDS (show PAFAH1B1 ELISA Kits) and identifies TP53 (show TP53 ELISA Kits) and IDH2 as targets for pre- or post-transplant therapy
Results highlight that non-canonical IDH mutations are relatively common in grade II and III gliomas: it is therefore important to analyze exon 4 of both IDH1 and IDH2 in these tumors. They also demonstrate that all IDH mutations, including the non-canonical ones are clonally distributed, a finding consistent with their driver role in gliomagenesis.
our findings highlight the role of IDH2 in skin melanogenesis in association with mitochondrial ROS (show ROS1 ELISA Kits) and suggest unique therapeutic strategies for the prevention of skin pigmentation.
Data (including data from studies using knockout mice) suggest that IDH2 plays role in modulating liver fatty acid metabolism in dietary fructose-induced NAFLD (show TSC2 ELISA Kits) (non-alcoholic fatty liver disease). This study was conducted in female mice; previous studies suggest that women are more prone to develop metabolic syndromes in response to fructose-sweetened beverages.
present study supports the central role of idh2 deficiency in inducing oxidative stress resulting from acrolein-induced disruption of mitochondrial redox status in the lung
IDH2 deficiency leads to increased mitochondrial ROS (show ROS1 ELISA Kits) levels, activation of NF-kappaB (show NFKB1 ELISA Kits) and apoptosis of IEC in DSS (show PMP22 ELISA Kits)-induced colitis.
present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63.
The disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38 (show CRK ELISA Kits)/cJun (show JUN ELISA Kits) NH2-terminal kinase (JNK (show MAPK8 ELISA Kits)) and p53 (show TP53 ELISA Kits), presumably induced by the elevation of mitochondrial reactive oxygen species (ROS (show ROS1 ELISA Kits)), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21 (show FGF21 ELISA Kits)) and the inhibition of NFkappaB signaling pathways.
We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase (show alphaKGDHC ELISA Kits) and induces histone modifications in an ACL (show APOC4 ELISA Kits)-dependent manner.Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart
Increased obesity resistance and insulin (show INS ELISA Kits) sensitivity in mice lacking the IDH2 gene has been documented.
treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD (show SOD2 ELISA Kits) expression, eNOS (show NOS3 ELISA Kits) phosphorylation and NO production in endothelial cells
Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.
The enzyme is highly sensitive to Mg(2 (show MCOLN1 ELISA Kits)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 ELISA Kits)+)] in mitochondrial energy metabolism.
Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 ELISA Kits) activity.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
, isocitrate dehydrogenase [NADP], mitochondrial
, oxalosuccinate decarboxylase
, NADP+-specific isocitrate dehydrogenase
, NADPH-specific isocitrate dehydrogenase
, isocitrate dehydrogenase 2 (NADP+), mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial-like