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Has low protease activity towards poly-ubiquitin chains (in vitro). Additionally we are shipping Josephin Domain Containing 1 Proteins (8) and many more products for this protein.
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In this study, the authors report that JOSD1 plays an important role in regulating type-I interferon (IFN-I)-mediated antiviral activity. JOSD1 physically interacts with SOCS1, which is an essential negative regulator of many cytokines signaling, and enhances SOCS1 stability by deubiquitinating K48-linked polyubiquitination of SOCS1.
The gain of function studies indicated that Josephin domain containing 1 activate NR5A1 gene expression.
JosD1, a membrane-associated DUB whose activity is regulated by ubiquitination, helps regulate membrane dynamics, cell motility, and endocytosis.
Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.
Josephin domain containing 1
, josephin domain-containing protein 1
, josephin domain-containing 1