Keratin 6A Proteins (KRT6A)

The protein encoded by KRT6A is a member of the keratin gene family. Additionally we are shipping KRT6A Antibodies (150) and KRT6A Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KRT6A 3853 P02538
KRT6A 16687 P50446
KRT6A 683313  
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Top KRT6A Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$230.67
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Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 15 to 18 Days
$672.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,580.50
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Escherichia coli (E. coli) Human His tag,S tag   100 μg Log in to see 15 to 18 Days
$608.00
Details

KRT6A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Keratin 6A (KRT6A) Interaction Partners

Human Keratin 6A (KRT6A) interaction partners

  1. Manipulating K6a phosphorylation or ubiquitin-proteasome system (UPS) activity may provide opportunities to harness the innate immunity of epithelia against infection.

  2. Cytokeratin 5/6 and CK8/18 immunohistochemistry on 150 cases of triple negative breast cancers was performed and association with various clinicopathological features was evaluated.

  3. Data indicate that cytokeratin 5/6 (CK5/6) is an independent prognostic biomarker in urothelial carcinoma and therefore can be used in the prognostic stratification of the patients with bladder cancer.

  4. Several missense polymorphisms in KRT6A, KRT6B and KRT6C that lead to a higher risk for dental caries.

  5. KRT6A genetic mutation is associate with the development of Pachyonychia Congenita in patients in Australia.

  6. we here describe a family with pachyonychia congenita K6a, manifesting atypical symptoms of impaired wound healing and cheilitis.

  7. Keratin-derived antimicrobial peptides (KDAMPs) and their synthetic analogs exhibit antimicrobial activity against bacterial pathogens.

  8. CK5/6, but not c-Met expression, seems to be important in lymphatic metastasis

  9. Genotype-phenotype correlations among PC patients with codon-125 mutation in KRT16 were established, while the phenotypes caused by the IVS8-2A>C mutation in KRT6A need further studies to confirm the rare feature of fissured tongue

  10. Data show that calretinin and CK5/6 were positive in 100 and 64% of mesotheliomas, and 92 and 31% of reactive effusions, respectively, and desmin was negative in all malignant cases and positive in 85% of reactive effusions.

  11. We observed a higher likelihood of oral leukokeratosis in individuals harboring KRT6A mutations.

  12. Phenotypic differences exist between KRT6A and KRT16 mutations support adoption of a new classification system.

  13. This report is the first case of pachyonychia congenita with laryngeal obstruction in which the gene mutation has been established (a deletional mutation in keratin 6a).

  14. Focal palmoplantar keratoderma is associated with mutations in keratin K6c in 3 families. 2 unrelated families have Asn172 del and the other has a deletion of AA 462-470. Review.

  15. these data highlight the possibility of a physiological role for K6/K16 heterodimers in keratinocyte cell migration, in addition to the heterodimer's known functions in cell differentiation and mechanical resilience.

  16. The mutation of 521T--> C in the K6A gene is the causing mutation in pachyonychia congenita type I.

  17. Mutations Y465H and N171D of the KRT16A gene were detected in the sporadic pachyonychia congenita cases.

  18. CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term.

  19. Four new missense and five known mutations in K6a, one new deletion and three previously identified missense mutations in K16, plus one known mutation in K17 are reported in pachyonychia congenita.

  20. PC-1 is due to mutations of the KRT16 gene or its expression partner KRT6A, wheres PC-2 is caused by mutations in the KRT17 or KRT6B genes.

Mouse (Murine) Keratin 6A (KRT6A) interaction partners

  1. Although K6a was not essential for mammary gland development, loss of both K6a and K6b resulted in an increase in PR-positive mammary epithelial cells and decreased proliferation after exposure to steroid hormones

  2. mK6a and mK75 thus exhibit temporally distinct, and spatially opposed, expression patterns in the companion layer (Cl) during postnatal anagen.

KRT6A Protein Profile

Protein Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified\; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene names and symbols associated with Keratin 6A Proteins (KRT6A)

  • keratin 6A (KRT6A)
  • keratin 6A (Krt6a)
  • similar to keratin complex 2, basic, gene 6a (LOC683313)
  • keratin, type II cytoskeletal 6A (KRT6A)
  • keratin, type II cytoskeletal 6A (LOC101112304)
  • 2310016L08Rik protein
  • CK-6A protein
  • CK6A protein
  • CK6C protein
  • CK6D protein
  • K6A protein
  • K6C protein
  • K6D protein
  • Krt2-6a protein
  • Krt2-6c protein
  • KRT6A protein
  • KRT6C protein
  • KRT6D protein
  • MK6a protein
  • mK6[a] protein

Protein level used designations for Keratin 6A Proteins (KRT6A)

cytokeratin 6A , cytokeratin 6C , cytokeratin 6D , keratin, epidermal type II, K6A , keratin, type II cytoskeletal 6A , type-II keratin Kb6 , 60-kDa keratin , CK-6A , K6A , cytokeratin-6A , keratin complex 2, basic, gene 6a , keratin complex 2, basic, gene 6c , keratin complex 2, gene 6a , keratin-6-alpha , keratin-6A , mK6-alpha , type II alpha-keratin IIC , keratin 6A , keratin 6 alpha , keratin IV , K6a keratin , keratin K6 , keratin, type II cytoskeletal 59 kDa, component IV , keratin, type II cytoskeletal 6C , LOW QUALITY PROTEIN: keratin, type II cytoskeletal 6A , keratin 6A, type II

GENE ID SPECIES
3853 Homo sapiens
16687 Mus musculus
408041 Gallus gallus
486523 Canis lupus familiaris
614456 Bos taurus
451918 Pan troglodytes
683313 Rattus norvegicus
100061595 Equus caballus
102164968 Sus scrofa
101112304 Ovis aries musimon
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