Keratin 9 (KRT9) ELISA Kits

Human Keratin 9 (KRT9) interaction partners

1. keratin 9 is an Hsp70 client protein and is expressed in human bladder cancer cells.

2. A novel heterozygous c.1369C>T transition (p.Leu457Phe) in exon 6 of the KRT9 gene was identified in four patients in a Chinese Family with Epidermolytic Palmoplantar Keratoderma.

3. During analyzing the sequences of KRT9 gene of a epidermolytic palmoplantar keratoderma (EPPK) pedigree, we found a new heterozygous missense mutation (488G>T) of exon 1 of KRT9 gene, which has not been reported before and does not exist in healthy individuals of the family and 100 unrelated individuals.

4. Results identified the missense mutation KRT9 c.487C>T, as a potential causative mutation in the large Uygur family with epidermolytic palmoplantar keratoderma.

5. KRT9 expression is significantly downregulated in human masticatory mucosa during wound healing

6. Findings suggest that dysregulated Keratin 9 expression is a consequence of Alzheimer's disease (AD).

7. Mutational analysis revealed a T to G transition in the coding DNA sequence, designated as c.470T>G (p.Met157Arg), a missense mutation in exon 1 of KRT9 in the proband and her brother, but not in unrelated healthy controls.

8. KRT9 gene mutation as a reliable indicator in the prenatal molecular diagnosis of epidermolytic palmoplantar keratoderma.

9. A heterozygous missense mutation c.482A to G in the KRT9 gene.

10. Our findings indicate that knuckle pads can be associated with epidermolytic palmoplantar keratoderma and the R163W mutation in a family with a genetic background different from that described here.

11. We identified a novel Eidermolytic Palmoplantar Keratoderma-causing mutation located in a region of the KRT9 gene, encoding a poorly conserved region of the protein that is not routinely screened for diagnostic purposes.

12. Data indicate that the node tumour burden could be accurately quantified based on the cytokeratin 19 (CK19) mRNA copy number.

13. A heterozygous transversional mutation, 488G-->A, was identified in exon 1 of KRT9 gene in all patients.

14. A substitution in arginine alters the charge and shape of KRT9 rod domain, disrupting the function of the helix initiation motif of keratins and compromising the integrity of filaments and weakening their stability in the epidermis of palms and soles.

15. KRT9 may play a complicated role in the genesis of epidermolytic palmoplantar keratoderma with knuckle pads and camptodactyly.

16. Study provides evidence that epidermolytic palmoplantar keratoderma in a large Chinese family may result from a novel duplication mutation (c.495_503dupCTCTTACTT) in the 1A rod domain of KRT9.

17. identified mRNA transcripts from three genes CDSN, LOR and KRT9, showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification

18. A c.T1206C substitution in the 2B domain of KRT 9 was identified.

19. The affected members of all five families possess mutations in the KRT9 gene that severely affect heterodimer formation with the type II keratin partner.

20. Genetic studies have revealed that K9 gene mutations are responsible for epodermolytic palmoplantar keratoderma.

Mouse (Murine) Keratin 9 (KRT9) interaction partners

1. Our data demonstrate that complete ablation of K9 is not tolerable in vivo and that K9 is required for terminal differentiation and maintaining the mechanical integrity of palmoplantar epidermis.

2. Intron 6 influences the transcriptional efficiency of the keratin 9 (K9, Krt1-9) gene by decreasing production of wild-type K9 and changing the expression of K9 proteins.