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Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. Additionally we are shipping KCP Kits (5) and KCP Proteins (3) and many more products for this protein.
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Metabolic profiling indicated increased energy expenditure in KCP-overexpressing mice and reduced expenditure in the KCP mutants with no effect on food intake or activity. These findings demonstrate that shifting the TGF-beta superfamily signaling with a secreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesity even when mice are fed a high-fat diet.
These data suggest that extracellular regulation of the TGF-beta/BMP signaling axis by KCP, and by extension possibly other cysteine-rich domain proteins, can attenuate both acute and chronic renal injury.
The data indicate an important role for KCP in attenuating the pathology of renal fibrotic disease.
role for KCP in modulating the responses between these anti- and profibrotic cytokines in the initiation and progression of renal interstitial fibrosis
Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.
, cysteine rich BMP regulator 2 (chordin-like)
, cysteine-rich BMP regulator 2
, cysteine-rich motor neuron 2 protein
, kielin/chordin-like protein 1
, cysteine rich BMP regulator 2 (chordin like)