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Location-regulated scaffold connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 2 Antibodies (82) and Kinase Suppressor of Ras 2 Proteins (7) and many more products for this protein.
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These observations suggest that, in the brain, KSR2 regulates energy balance via control of feeding behavior and adaptive thermogenesis, while a second KSR2-dependent mechanism, functioning through one or more other tissues, modulates sensitivity to leptin (show LEP ELISA Kits) and activators of the energy sensor AMPK (show PRKAA1 ELISA Kits).
A pleiotropic effect of KSR2-rs7973260 was found on the risk of metabolic syndrome, severe hypertriglyceridemia, and diabetes.
KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 ELISA Kits))/ORAI1 (show ORAI1 ELISA Kits) puncta formation, which is correlated with cytoskeleton disorganization.
Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf (show RAF1 ELISA Kits)-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells.
study demonstrated that miR (show MLXIP ELISA Kits)-31 upregulated IL-2 (show IL2 ELISA Kits) expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation
The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis.
KSR (show KSR1 ELISA Kits) interacts with a regulatory Raf (show RAF1 ELISA Kits) molecule in cis to induce a conformational switch of MEK (show MAP2K1 ELISA Kits), facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 ELISA Kits) molecule in trans
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia (show BCL11A ELISA Kits) cells.
hKSR-2, a new member of the KSR (show KSR1 ELISA Kits) family, negatively regulates Cot (show MAP3K8 ELISA Kits)-mediated MAP kinase (show MAPK1 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) pathway signaling
We find that while hKSR-2 blocks MEKK3 activation, it has little to no effect on other members of the MAP3K family, including MEKK4, TAK1 (show MAP3K7 ELISA Kits), and Ras-Raf (show RAF1 ELISA Kits), suggesting that its effects are selective.
These data indicate that KSR2 functions in a cell non-autonomous fashion to regulate GH-stimulated IGF-1 (show IGF1 ELISA Kits) expression in the liver of neonatal mice, which plays a key role in the development of body length.
KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 ELISA Kits))/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization.
KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways
The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24
KSR2 regulates AMPK (show PRKAA1 ELISA Kits)-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.
The protein phosphatase calcineurin selectively interacts with KSR2 and KSR2 uniquely contributes to Ca2 (show CA2 ELISA Kits)+-mediated ERK (show EPHB2 ELISA Kits) signaling.
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
kinase suppressor of Ras 2