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KIF11 encodes a motor protein that belongs to the kinesin-like protein family. Additionally we are shipping KIF11 Antibodies (121) and KIF11 Proteins (4) and many more products for this protein.
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results demonstrate that Eg5 is phosphorylated in cultured cells by Src (show SRC ELISA Kits) family kinases (SFKs) at three sites in the motor head: Y125, Y211, and Y231. Mutation of these sites diminishes motor activity in vitro, and replacement of endogenous Eg5 with phosphomimetic Y211 in LLC-Pk1 (show PKLR ELISA Kits) cells results in monopolar spindles, consistent with loss of Eg5 activity.
Results show that KIF11 mRNA expression was upregulated in prostate cancer tissues and associated with aggressive characteristics.
Eg5 is overexpressed in the livers of the hepatocellular carcinoma patients and is predictive of poor prognosis.
The data suggested that Eg5 may be identified as a novel prognostic biomarker and targeting Eg5 seems to be a novel strategy for LSCC treatment.
Progressive retinal degeneration in KIF11-related retinopathy indicates a role for KIF11 not only in ocular development but also in maintaining retinal morphology and function. The remarkable variability of the ocular phenotype suggests four different types of retinopathy which may overlap.
Among the detected mutations, LRP5 (show LRP5 ELISA Kits) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (show NDP ELISA Kits) (3/31, 9.7%), FZD4 (show FZD4 ELISA Kits) (2/31, 6.5%), TSPAN12 (1/31, 3.2%), and KIF11 (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.
Data show that the kinesin 5 (Eg5) binding time has less sensitivity on MCF7 as compared to bovine brain microtubules.
mixing of Eg5 and MTs (show TIMM8A ELISA Kits) produced a range of spatiotemporal dynamics
that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
KIF11 is an important regulator of activity in oesophageal and colorectal tumor stem cells.
Data suggest that poleward transport of TPX2, which requires dynein and Eg5, down-regulates its microtubule nucleating activity near kinetochores and links microtubules to dynein for incorporation into the spindle.
Fbxo30 (show FBXO30 ELISA Kits)-Eg5 interaction as a critical checkpoint in mammopoiesis.
Data show that the STIM1 (show STIM1 ELISA Kits) Ksp (Eg5)-cre knockout mice produced more urine compared to control.
Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons.
Disruption of the in vivo interaction of KIF11 with ZBP1 (show ZBP1 ELISA Kits) delocalizes beta-actin (show ACTB ELISA Kits) mRNA and affects cell migration.
These results suggest that 4-(N-(2-(N-acetylcysteine-S-yl) acetyl) amino)-4'- (N-(2-(N-(triphenylmethyl)amino)acetyl)amino)azobenzene could be used as photochromic inhibitor of Eg5 to achieve photocontrol of living cells.
incorporation of photochromic molecules into the key region of loop L5 facilitates the photocontrol of the function of kinesin Eg5.
Finally, when kinesin spindle protein (KSP) siRNA was encapsulated in lipid nanoparticles containing a modest amount of PEG (show PAEP ELISA Kits), the proliferation of endothelial cells was inhibited due to the efficient knock down of KSP mRNA.
These results show that intratumoral electro-transfer of siRNA is feasible and kinesin spindle protein (KSP)-specific siRNA may provide a novel strategy for therapeutic intervention.
observations explain the poleward accumulation of Eg5 in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 movement on microtubules, whereas depletion of the Eg5-binding protein TPX2 (show DAZL ELISA Kits) resulted in end-directed Eg5 movement.
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.
TR-interacting protein 5
, kinesin-like protein 1
, kinesin-like protein KIF11
, kinesin-like spindle protein HKSP
, kinesin-related motor protein Eg5
, thyroid receptor-interacting protein 5
, kinesin 11
, kinesin-like 1