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KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008].. Additionally we are shipping KIF18A Antibodies (40) and KIF18A Proteins (3) and many more products for this protein.
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High KIF18A expression is associated with invasion and metastasis of hepatocellular carcinoma.
Low post translational modifications of KIF18A protein is associated with neoplasms.
KIF18a role in microtubule assembly
Cdk1 (show CDK1 ELISA Kits)-mediated inhibitory phosphorylation of Kif18A promotes chromosome oscillations in early metaphase. PP1 (show PPA1 ELISA Kits) induces metaphase plate thinning by directly dephosphorylating Kif18A.
Confocal microscopy shows that cells expressing SUMO-resistant Kif18A display a compromised dissociation of BubR1 (show BUB1B ELISA Kits) from kinetochores after anaphase onset.
that the human mitotic kinesin-8, KIF18A, directly interacts with PP1gamma through a conserved RVxF motif
the motion of yeast (Kip3) and human (Kif18A) kinesin-8s
Mechanisms controlling the temporal degradation of Nek2A (show NEK2 ELISA Kits) and Kif18A by the APC (show APC ELISA Kits)/C-Cdc20 (show CDC20 ELISA Kits) complex.
Kif18A (kinesin-8) attenuates centromere movement by directly promoting microtubule pausing in a concentration- dependent manner.
there is a mutual regulation of kinetochore MT plus-end dynamics and Kif18A accumulation, which may contribute to the highly regulated and ordered changes in kinetochore spindle microtubule dynamics during chromosome congression and oscillation
Kif18a is specifically required for mitotic progression during germ line development.
In conclusion, Kif18a is critical for colorectal carcinogenesis in the setting of inflammation by mechanisms of increased PI3K-AKT (show AKT1 ELISA Kits) signaling.
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005
kinesin family member 18A
, kinesin-like protein KIF18A
, kinesin-like protein KIF18A-like
, N-8 kinesin
, kinesin superfamily protein 18A