Kinesin Family Member 1A (KIF1A) ELISA Kits

The protein encoded by KIF1A is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Additionally we are shipping KIF1A Antibodies (15) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse KIF1A KIF1A 16560  
KIF1A 547 Q12756
Anti-Rat KIF1A KIF1A 363288  
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Top KIF1A ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.051 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details

More ELISA Kits for KIF1A Interaction Partners

Mouse (Murine) Kinesin Family Member 1A (KIF1A) interaction partners

  1. these findings support a primary role for KIF1A in the anterograde transport of BACE1.

  2. propose that KIF1A is essential for the survival and function of sensory neurons.

  3. The Doublecortin specifically enhances binding of the ADP-bound Kif1a motor domain to microtubules. Dcx is essential for the function of Kif1a, a kinesin-3 motor protein that traffics synaptic vesicles.

  4. This study demonstrated that KIF1A is indispensable for BDNF-mediated hippocampal synaptogenesis and learning enhancement induced by enrichment.

  5. The KIF1A-microtubule binding free energy is dominated by van der Waals interactions and electrostatic interactions.

  6. crystal structures of monomeric KIF1A with three transition-state analogs; structures show that KIF1A uses two microtubule-binding loops in an alternating manner to change its interaction with microtubules during the ATP hydrolysis cycle

  7. propose a model mechanism for microtubule activation of Mg-ADP release from KIF1A

Zebrafish Kinesin Family Member 1A (KIF1A) interaction partners

  1. The findings suggest that cyclin B1 mRNA-Staufen1 protein complexes are transported toward the animal pole of zebrafish oocytes by the plus-end-directed motor protein Kinesin1 along microtubules, and that a common mRNA transport machinery functions in zebrafish and Xenopus oocytes, although its transport direction is opposite due to different organizations of microtubules.

Human Kinesin Family Member 1A (KIF1A) interaction partners

  1. Consistent with the differential clinical and structural impact, TUBB2AA248V does not drastically affect TUBB2A binding to KIF1A, nor mitotic spindle bipolarity. Overall, our data demonstrate a pathogenic role of the p.D417N substitution that is different from previously reported TUBB2A mutations and expand the phenotypic spectrum associated with mutations in this gene.

  2. We report a child with a de novo KIF1A gene mutation who was found to have bilateral optic nerve hypoplasia and atrophy.

  3. BORC and Arl8 function upstream of two structurally distinct kinesin types: kinesin-1 (KIF5B) and kinesin-3 (KIF1Bbeta and KIF1A).

  4. De novo missense variant affecting the motor domain of KIF1A was identified as a cause of PEHO syndrome.

  5. Mutations outside the motor domain of the gene can cause (recessive) SPG30 and extends the genotype-phenotype association for KIF1A-related diseases.

  6. This study further delineates clinical features of de novo KIF1A mutations

  7. KIF1A variants in dominant and sporadic forms of hereditary spastic paraparesis.

  8. KIF1A should be considered a candidate gene for hereditary paraplegias regardless of inheritance pattern.

  9. Findings provide evidence that de novo missense mutations in the motor domain of KIF1A cause a more severe phenotype that overlaps with that associated with recessive mutations in the same gene.

  10. Data demonstrated that KIF1A promoter methylation can distinguish breast cancer cases from controls in plasma and was inversely associated with DNA repair capacity.

  11. This study establishes an essential role of the CC1-FHA dimer for KIF1A/unc-104-mediated neuronal transport.

  12. Cytoplasmic dynein is active during minus- and plus-end directed motion, whereas kinesin is only active in the plus direction.

  13. The CC1-FHA tandem likely functions as a hub for controlling the dimerization and activation of KIF1A.

  14. mutations in the KIF1A gene are responsible for SPG30 in two autosomal recessive HSP families

  15. The authors find that Arl8B is required for kinesin-1 recruitment to Salmonella-containing vacuoles, migration of the vacuoles to the cell periphery 24 h after infection and for cell-to-cell transfer of bacteria to neighbouring cells.

  16. Mutations in KIF1A are a rare cause of hereditary sensory and autonomic neuropathy type 2.

  17. A mutation in KIF1A is associated with a pure form of hereditary spastic paraparesis. (HSP) cases in a single inbred family.

  18. Promoter hypermethylation of KIF1A and EDNRB is a frequent event in primary HNSCC, and these genes are preferentially methylated in salivary rinses from HNSCC patients.

  19. KIF1A mediates neuronal transport at a high velocity and processivity in vivo

  20. Results suggest that the intramolecular FHA-CC2 interaction negatively regulates KIF1A activity by inhibiting MT binding and dimerization of KIF1A, and point to a novel role of the FHA domain in the regulation of kinesin motors.

KIF1A Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with KIF1A

  • kinesin family member 1A (KIF1A) antibody
  • kinesin family member 1A (kif1a) antibody
  • kinesin family member 1A (Kif1a) antibody
  • kinesin family member 1Aa (kif1aa) antibody
  • ATSV antibody
  • C2orf20 antibody
  • C630002N23Rik antibody
  • Gm1626 antibody
  • HSN2C antibody
  • Kns1 antibody
  • MRD9 antibody
  • SPG30 antibody
  • UNC104 antibody

Protein level used designations for KIF1A

kinesin family member 1A , N-3 kinesin , axonal transporter of synaptic vesicles , kinesin heavy chain member 1A , kinesin-like protein KIF1A , kinesin, heavy chain, member 1A, homolog of mouse , microtubule-based motor KIF1A , tmp_locus_27 , unc-104- and KIF1A-related protein , neuron-specific kinesin motor KIF1A

GENE ID SPECIES
716855 Macaca mulatta
761007 Strongylocentrotus purpuratus
100013596 Monodelphis domestica
100057836 Equus caballus
100080479 Ornithorhynchus anatinus
100127546 Xenopus (Silurana) tropicalis
100565891 Anolis carolinensis
100582798 Nomascus leucogenys
16560 Mus musculus
100330443 Danio rerio
424849 Gallus gallus
547 Homo sapiens
486202 Canis lupus familiaris
527883 Bos taurus
363288 Rattus norvegicus
100517246 Sus scrofa
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