anti-Kruppel-Like Factor 7 (Ubiquitous) (KLF7) Antibodies

Zebrafish Kruppel-Like Factor 7 (Ubiquitous) (KLF7) interaction partners

1. In the spinal cord, klf7- and klf6a-expressing cells are found in both the dorsal and ventral horns. Numerous sensory structures (e.g. auditory, lateral line, olfactory and visual) and several motor nuclei (e.g. oculomotor, trigeminal, and vagal motor nuclei) contain klf7- and/or klf6a-expressing cells

2. Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.

Human Kruppel-Like Factor 7 (Ubiquitous) (KLF7) interaction partners

1. e report 4 unrelated individuals with de novo KLF7 missense variants who share similar clinical features of developmental delay/ID, hypotonia, feeding/swallowing issues, psychiatric features and neuromuscular symptoms, and add to the knowledge about the phenotypic spectrum associated with KLF7 haploinsufficiency.

2. KLF7 is decreased in women with polycystic ovary syndrome, but no significant association was observed between KLF7 and the BMI, total testosterone, and insulin resistance

3. Kruppel family member KLF7 promotes the corneal progenitor cell state; on many genes, KLF7 antagonized the corneal differentiation-promoting KLF4.

4. KLF7 has an important role in gastric cancer (GC) progression, as it inhibits GC cell migration and may serve as a prognostic marker

5. Higher expression of TLR4 and KLF7 may play a vital role in the process of inflammation induced by obesity in visceral adipose tissue

6. a dominant mutation in FBXO38 causes adult-onset, progressive spinal muscular atrophy with calf predominance

7. KLF7 was upregulated by morphine at both the transcriptional and the translational levels, promoting cell growth up to day 4

8. The gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes.

9. KLF7 may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin sensitivity in peripheral tissues.

10. We identified a novel association between the minor A-allele of KLF7 and protection against obesity in the Danish population

Mouse (Murine) Kruppel-Like Factor 7 (Ubiquitous) (KLF7) interaction partners

1. Our findings suggest that KLF7 promotes DPSN axonal plasticity and the formation of synapses with motor neurons at the caudal spinal cord, leading to improved functional recovery

2. was upregulated in quiescent satellite cell and nonproliferating myoblasts.

3. Data show that adult corticospinal tract (CST) neurons failed to up-regulate KLF7 in response to axon injury, and overexpression of VP16-KLF7 in vivo promoted both sprouting and regenerative axon growth in the CST of adult mice.

4. lack of a KLF family member affects dopaminergic neuron development.

5. KLF7 inactivation in Klf7-null mice decreases the expression of the neurogenic marker brain lipid-binding protein/fatty acid-binding protein 7 (BLBP/FABP7) in neural stem cells (NSCs).

6. Klf7 gene ablation reduces TrkA expression in sensory neurons due to effect on cell death

7. Klf7 is important for neuronal morphogenesis in selected regions of the central nervous system.

8. mice without Kruppel-like factor 7 activity die at birth and display hypoplastic olfactory bulbs which lack peripheral innervation

9. Cooperation between Brn3a and Klf7 is required for endogenous TrkA gene expression and the survival of nociceptive sensory neurons.

10. Results advance knowledge of transcriptional regulation of olfactory neurogenesis and KLF7 action.

11. Upregulation of adiponectin protein by (-)-catechin may involve, at least in part, suppression of KLF7 in 3T3-L1 cells.