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LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. Additionally we are shipping LASP1 Antibodies (114) and LASP1 Proteins (13) and many more products for this protein.
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Data shows that LASP1 is significantly upregulated in breast cancer tissues and cell lines, and its upregulation significantly associated with disease progression. Also, LASP1 was identified as a target gene of miR (show MLXIP ELISA Kits)-133a, and its expression negatively regulated by miR (show MLXIP ELISA Kits)-133a in breast cancer cells.
An in vitro study showed that overexpression of miR (show MLXIP ELISA Kits)-133b inhibited the proliferation, migration, and invasion of HepG2 and Hep3B cells. Similarly, knockdown of LASP1 reduced HepG2 and Hep3B cell proliferation, migration, and invasion.
Findings indicated that LASP-1, as a downstream target of SOX9 (show SOX9 ELISA Kits), may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion.
miR (show MLXIP ELISA Kits)-203a-3p suppresses tumor growth and metastasis through targeting LASP1 in NPC (show NPC1 ELISA Kits).
LASP1 silencing elicited effects similar to miR-326 overexpression on HCC cells.
A combination of low 14-3-3sigma and high LASP1 expression shows a worse trend with overall survival of colorectal cancer patients.
Furthermore, we identify flotillin-1 (FLOT1 (show FLOT1 ELISA Kits)) and histone H1 (show H1F0 ELISA Kits) as downstream factors for cytoplasmic and nuclear pathway of S100A11 (show S100A11 ELISA Kits), which are required for LASP1-S100A11 (show S100A11 ELISA Kits) axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.
Overexpression of LASP-1 in thyroid cancer tissues.LASP-1 role in thyroid cancer cell proliferation and invasion.LASP-1 is an oncogene (show RAB1A ELISA Kits).
Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma.
Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR (show MLXIP ELISA Kits)-145.
Results defined LASP1 as a direct target gene for HIF1alpha (show HIF1A ELISA Kits) upregulation that is critical for metastatic progression of PDAC.
Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
LIM-nebulette (show NEBL ELISA Kits), Lasp-1, and zyxin (show ZYX ELISA Kits) may play an important role in the organization of focal adhesions
Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM (show MMRN1 ELISA Kits) proteins.
Data suggest that there are no functional differences between human and mouse LASP-1.
The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
LIM and SH3 domain protein 1
, LIM and SH3 protein 1
, lasp1 protein
, metastatic lymph node gene 50 protein
, MLN 50
, 40 kDa phosphoprotein
, phosphoprotein Lasp-1