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LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. Additionally we are shipping LASP1 Antibodies (111) and LASP1 Proteins (13) and many more products for this protein.
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LASP1 silencing elicited effects similar to miR-326 overexpression on HCC cells.
A combination of low 14-3-3sigma and high LASP1 expression shows a worse trend with overall survival of colorectal cancer patients.
Furthermore, we identify flotillin-1 (FLOT1 (show FLOT1 ELISA Kits)) and histone H1 (show H1F0 ELISA Kits) as downstream factors for cytoplasmic and nuclear pathway of S100A11 (show S100A11 ELISA Kits), which are required for LASP1-S100A11 (show S100A11 ELISA Kits) axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.
Overexpression of LASP-1 in thyroid cancer tissues.LASP-1 role in thyroid cancer cell proliferation and invasion.LASP-1 is an oncogene (show RAB1A ELISA Kits).
Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma.
Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR (show MLXIP ELISA Kits)-145.
LASP1 enhances the expression and secretion of MMPs, favoring breast cancer cell migration and invasiveness.
miR (show MLXIP ELISA Kits)-218 contributes to PE by targeting LASP1 to inhibit trophoblast invasion
The correlation between LIM and SH3 domain-containing protein expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker
LASP-1 contributes to the formation and progression of prostate cancer through a NF-kappaappa B pathway.
Results defined LASP1 as a direct target gene for HIF1alpha (show HIF1A ELISA Kits) upregulation that is critical for metastatic progression of PDAC.
Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
LIM-nebulette (show NEBL ELISA Kits), Lasp-1, and zyxin (show ZYX ELISA Kits) may play an important role in the organization of focal adhesions
Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM (show MMRN1 ELISA Kits) proteins.
Data suggest that there are no functional differences between human and mouse LASP-1.
The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
LIM and SH3 domain protein 1
, LIM and SH3 protein 1
, lasp1 protein
, metastatic lymph node gene 50 protein
, MLN 50
, 40 kDa phosphoprotein
, phosphoprotein Lasp-1