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LACE1 encodes a protein with possible ATPase function.
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Increased expression of LACE1 partitions p53 (show TP53 Proteins) to mitochondria, causes reduction in nuclear p53 (show TP53 Proteins) content and induces apoptosis. Thus, LACE1 mediates mitochondrial translocation of p53 (show TP53 Proteins) and its transcription-independent apoptosis.
This study establishes LACE1 as a novel factor with a crucial role in mitochondrial protein (show COX6B2 Proteins) homeostasis.
association between bipolar disorder and two SNPs in the gene LACE1
This gene encodes a protein with possible ATPase function. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene.
lactation elevated 1
, lactation elevated protein 1
, lactation elevated protein 1-like
, ATPase family gene 1 homolog
, CG8520 gene product
, protein AFG1 homolog