Laminin, gamma 2 Proteins (LAMC2)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Additionally we are shipping LAMC2 Antibodies (70) and LAMC2 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LAMC2 3918 Q13753
LAMC2 16782  
LAMC2 192362  
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Top LAMC2 Proteins at

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days

LAMC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine) ,
Rat (Rattus)

More Proteins for Laminin, gamma 2 (LAMC2) Interaction Partners

Human Laminin, gamma 2 (LAMC2) interaction partners

  1. It regulates tumor development of tongue squamous cell carcinoma together with LINC00511 and miR-765.

  2. Laminin 332 was expressed specifically within papillary thyroid carcinoma (PTC) tissue. The frequency of laminin 332 gamma2 chain expression was significantly correlated with cervical lymph node metastasis. Invasiveness increased as the expression of laminin 332 gamma2 increased in the tested PTC cell lines.

  3. Study found that high expression of LAMC2 was significantly associated with shorter disease-free survival in GC and, that expression of LAMC2 was significantly upregulated when PCDH8 was overexpressed.

  4. The results of this study highlight the value of LAMC2 as a marker of cancer invasion. LAMC2-positive foci in leukoplakia suggest an imminent risk of cancer.

  5. Results indicate that LAMC2-Dox mice expressing the human protein are unable to sustain structuring of a proper basement membrane (BM) at the interface between ameloblasts and maturing enamel. This failure may be related to the atypical composition of the BM in the maturation stage and reaffirms that the atypical BM is essential for enamel maturation.

  6. Overexpression of LAMC2 and knockdown of CD82 markedly promoted GC cell invasion and activated EGFR/ERK1/2-MMP7 signaling via upregulation of the expression of phosphorylated (p)-EGFR, p-ERK1/2 and MMP7.

  7. The data presented provide a novel insight into how CDX2 is implicated in the transcriptional regulation of LAMC2 in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha is present.

  8. Seventeen percent of the patients were compound heterozygous or homozygous for mutations in the gene LAMA3, 59% carried mutations in both alleles of LAMB3, and 12% were homozygous for mutations in LAMC2. In nine patients with severe generalized JEB, detection of two mutations in one of the genes LAMA3, LAMB3, or LAMC2 was not possible, so the molecular basis of disease could not be clarified completely

  9. our results strongly suggest that laminin g2 may be a potential prognostic biomarker and therapeutic target in colorectal cancer.

  10. Laminin expression depends on Ecad loss and allows Ecad-defective gastric cancer cells to survive and invade.

  11. findings strongly indicate that Ln-gamma2 is an attractive biomarker for detecting early stages of UC and for monitoring recurrence

  12. Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT and may be a potential therapeutic target.

  13. The positive expression of laminingamma2 and the tumor differentiation were independent risk factors influencing the prognosis of EHCC patients.

  14. LAMC2 is a novel non-small cell lung cancer prognostic factor.

  15. Diagnostic value of p40 and LN332 in metaplastic spindle cell carcinoma of the breast was found to be less than that of routinely used markers (p63 and cytokeratins). LN332 showed staining in a significant proportion of phyllodes tumours and sarcomas.

  16. The elevated expression of LAMC2 on cancer cells appears to drive tumorigenesis through its interactions with several cell-surface receptors

  17. Molecular expression of MMP-7, laminin c2 or EGFR, and their combinations, may be associated with gastric cancer tumor aggressiveness

  18. Through an unbiased genetic approach involving a combination of QTL mapping and positional cloning, we demonstrate that Col17a1 is a strong genetic modifier of the non-Herlitz JEB that develops in Lamc2(jeb) mice

  19. LAMC2 is expressed at a higher level in ectopic endometrium (Ec) from women with endometriosis compared with eutopic endometrium (Eu) from women with endometriosis.

  20. The active site of gamma2pf to the N-terminal epidermal growth factor-like repeat.

Mouse (Murine) Laminin, gamma 2 (LAMC2) interaction partners

  1. Study show that integrin alpha9beta1 antagonizes both alpha3beta1-dependent mTLD/BMP-1 expression and basement membrane (BM) assembly/maturation. These findings indicate a complex interplay between these two integrins whereby alpha3beta1 promotes, and coordinately, alpha9beta1 inhibits mTLD/BMP-1 production and laminin-gamma2 processing to effect timely BM assembly and maturation during wound healing.

  2. Data suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT and may be a potential therapeutic target.

  3. Periostin was associated with laminin gamma2, and this association enhanced the proteolytic cleavage of the laminin gamma2 long form to produce its short form.

  4. mutant mice develop a progressive blistering disease validated at the gross and microscopic levels to closely resemble generalized non-Herlitz junctional epidermolysis bullosa

  5. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2

  6. Thymosin beta(4) stimulates Lamc2 production independent of TGF-beta.

  7. agrin and perlecan cluster with laminin-2 to contribute to assembly of aneural AChR clusters that precede neural agrin release as well as affect later NMJ development

  8. Laminin gamma2 and laminin-332, despite their prominence in the lung, have a minimal role in lung development through the saccular stage.

  9. integrin alpha3beta1 delays keratinocyte migration during wound re-epithelialization, by binding to the laminin-332 that is newly deposited on the wound bed.

  10. Protein production was in excess of the amount required to form heterotrimeric laminin-332 and was associated with the migrating epithelial sheet, suggesting a potential role in wound healing for monomeric laminin-gamma2.

  11. Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells.

LAMC2 Protein Profile

Protein Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain\; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.

Gene names and symbols associated with Laminin, gamma 2 Proteins (LAMC2)

  • laminin subunit gamma 2 (LAMC2)
  • laminin, gamma 2 (Lamc2)
  • laminin subunit gamma 2 (Lamc2)
  • AA589349 protein
  • B2T protein
  • BM600 protein
  • CSF protein
  • EBR2 protein
  • EBR2A protein
  • LAMB2T protein
  • LAMC2 protein
  • LAMNB2 protein

Protein level used designations for Laminin, gamma 2 Proteins (LAMC2)

laminin 5 gamma 2 subunit , laminin subunit gamma-2 , laminin-5 gamma 2 , laminin, gamma 2 , laminin, gamma 2-like , laminin 5 gamma 2 , BM600-100kDa , CSF 140 kDa subunit , cell-scattering factor 140 kDa subunit , epiligrin subunit gamma , kalinin subunit gamma , ladsin 140 kDa subunit , laminin B2t chain , large adhesive scatter factor 140 kDa subunit , nicein subunit gamma , kalinin/nicein/epiligrin 100 kDa subunit , laminin gamma2 chain , laminin-5 subunit gamma , nicein, 100kD , nicein, 100kDa , lamimin, gamma 2

408043 Gallus gallus
442939 Canis lupus familiaris
457571 Pan troglodytes
511043 Bos taurus
715212 Macaca mulatta
100216328 Ovis aries
3918 Homo sapiens
16782 Mus musculus
791245 Equus caballus
192362 Rattus norvegicus
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