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Leucine Rich Repeat (In FLII) Interacting Protein 1 Proteins (LRRFIP1)

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. Additionally we are shipping Leucine Rich Repeat (In FLII) Interacting Protein 1 Antibodies (97) and Leucine Rich Repeat (In FLII) Interacting Protein 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LRRFIP1 16978 Q3UZ39
LRRFIP1 9208 Q32MZ4
Rat LRRFIP1 LRRFIP1 367314 Q66HF9
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Top Leucine Rich Repeat (In FLII) Interacting Protein 1 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human LRRFIP1 Protein. 100 μg 11 to 18 Days
$682.25
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LRRFIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,

More Proteins for Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1) Interaction Partners

Mouse (Murine) Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1) interaction partners

  1. Experiments in nude mice demonstrated better response of LRRFIP1 overexpressing glioblastoma multiforme xenografts to teniposide.

  2. regulates a rapid type I interferon response

  3. LRRFIP1 and its downstream partner beta-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon

Human Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1) interaction partners

  1. Results show that LRRFIP-1 is mainly produced by keratinocytes in the unwounded skin but is upregulated in both keratinocytes and fibroblasts in response to wounding, suggesting a role in the wound repair process.

  2. Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/beta-catenin signaling pathway.

  3. High GCF2 expression is associated with hepatoma.

  4. Higher baseline LRRFIP1 expression in human glioblastoma multiforme tissue (n=60) is associated with better prognosis upon later treatment with teniposide.

  5. Data indicate that LRRFIP1 knockdown increased resting TNF mRNA level altered the ncRNA abundance at the LRRFIP1 binding region.

  6. Eight SNPs (rs7575941, rs3769053, rs11689421, rs3820808, rs11680012, rs3806505, rs6739130, and rs11686141) showed evidence of association with at least two adiposity phenotypes and plasma levels of one marker of inflammation.

  7. The FLI-interacting domain of LRRFIP1 forms a classic parallel, homodimeric coiled coil with 10 heptad repeats and 22 helical turns.

  8. GCF2/LRRFIP1 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion.

  9. LRRFIP1 is phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures.

  10. An association study of 6 of the 63 genes in 4235 cases and 6379 controls showed a putative association with myocardial infarction for COMMD7 (COMM domain-containing protein 7) and a major deviation from the null hypo thesis for LRRFIP1.

  11. GCF2/LRRFIP1 appears to act as a repressor and occupies the -308 site in cells that do not make TNF-alpha.

  12. Immediately following lipopolysaccharide stimulation, both LRRFIP2 and Flap-1/LRRFIP1 compete with Fliih for interacting with MyD88 to activate the signaling.

Cow (Bovine) Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1) interaction partners

  1. ATG16 L1 was identified as a direct target of miR874 and demonstrated to be positively associated with autophagy. Reducing the expression of ATG16L1 and inhibiting the occurrence of autophagy sensitized gastric cancer cells to chemotherapy.

Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1) Protein Profile

Protein Summary

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Gene names and symbols associated with LRRFIP1

  • leucine rich repeat (in FLII) interacting protein 1a (lrrfip1a)
  • LRR binding FLII interacting protein 1 (LRRFIP1)
  • leucine rich repeat (in FLII) interacting protein 1 (Lrrfip1)
  • LRR binding FLII interacting protein 1 (Lrrfip1)
  • AU024550 protein
  • FLAP-1 protein
  • FLAP1 protein
  • FLIIAP1 protein
  • GCF-2 protein
  • GCF2 protein
  • hm:zeh1367 protein
  • HUFI-1 protein
  • LRRFIP1 protein
  • TRIP protein
  • wu:fc06b04 protein
  • wu:fi15c07 protein
  • zeh1367 protein

Protein level used designations for LRRFIP1

leucine rich repeat (in FLII) interacting protein 1 , leucine-rich repeat flightless-interacting protein 1-like , FLAP (FLI LRR associated protein) , FLI-LRR-associated protein 1 , H186 FLAP , LRR FLII-interacting protein 1 , flap-1 , leucine-rich repeat flightless-interacting protein 1 , GC-binding factor 2 , NEDD8-conjugating enzyme , TAR RNA-interacting protein

GENE ID SPECIES
407677 Danio rerio
428996 Gallus gallus
460050 Pan troglodytes
100066467 Equus caballus
100076391 Ornithorhynchus anatinus
100462541 Pongo abelii
16978 Mus musculus
9208 Homo sapiens
367314 Rattus norvegicus
477419 Canis lupus familiaris
616994 Bos taurus
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