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Leucine-Rich, Glioma Inactivated 1 (LGI1) ELISA Kits

LGI1 is rearranged as a result of translocations in glioblastoma cell lines. Additionally we are shipping Leucine-Rich, Glioma Inactivated 1 Antibodies (110) and Leucine-Rich, Glioma Inactivated 1 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
LGI1 9211 O95970
LGI1 56839 Q9JIA1
LGI1 252892 Q8K4Y5
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Top Leucine-Rich, Glioma Inactivated 1 ELISA Kits at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.039 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$910.56
Details
Mouse 7.81 pg/mL 31.25-2000 pg/mL   96 Tests Log in to see 15 to 18 Days
$910.56
Details
Rat 0.08 ng/mL   96 Tests Log in to see 15 to 18 Days
$910.56
Details

More ELISA Kits for Leucine-Rich, Glioma Inactivated 1 Interaction Partners

Human Leucine-Rich, Glioma Inactivated 1 (LGI1) interaction partners

  1. The clinical phenotypes of anti-LGI1 encephalitis and anti-Caspr2 (show CNTNAP2 ELISA Kits) encephalitis have been described in more detail including data on treatment and long-term follow-up. Lumping patients with anti-LGI1, anti-Caspr2 (show CNTNAP2 ELISA Kits) antibodies or lacking both, should be considered obsolete--{REVIEW}

  2. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 (show ADAM22 ELISA Kits) and ADAM23 (show Adam23 ELISA Kits) play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy

  3. Autosomal dominant epilepsy with auditory features family due to a novel LGI1 mutation.

  4. Clinical analysis of a lateral temporal lobe epilepsy cohort from Turkey and genetic contribution of LGI1 to autosomal dominant lateral temporal lobe epilepsy phenotype

  5. Report of three novel LGI1 mutations, a microdeletion of exon 2 and two missense mutations in exon 8, occurring in two autosomal dominant lateral temporal epilepsy families and in one sporadic patient with lateral temporal epilepsy

  6. study found no cryptic imbalances were in LGI1 in partial epilepsy with auditory features (PEAF) patients, suggesting that LGI1 microdeletions are not a frequent cause of PEAF

  7. The Multiplex ligation-dependent probe amplifications analysis did not reveal any pathogenic changes in the LGI1 gene. Chromosomal rearrangements involving the LGI1 gene were not identified in our series of familial or sporadic LTE.

  8. A new LGI1 missense mutation is identified in a large Korean family with autosomal dominant lateral temporal lobe epilepsy.

  9. Seven LGI1-affected individuals report auditory aura (show AURKA ELISA Kits) and one visual aura (show AURKA ELISA Kits); three families with autosomal dominant epilepsy and auditory features have novel LGI1 mutations.

  10. Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma.

Mouse (Murine) Leucine-Rich, Glioma Inactivated 1 (LGI1) interaction partners

  1. LGI1 is expressed at the axonal initial segment and regulates action potential firing by setting the density of the axonal Kv1.1 channels.

  2. LGI1 has a role in regulating cortical development, which is increasingly becoming recognized as one of the causes of idiopathic epilepsy.

  3. LGI1 and ADAM22 (show ADAM22 ELISA Kits) form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95 (show DLG4 ELISA Kits)

  4. Review article demonstrating that LGI1 may be an essential player in the development of the brain

  5. Glutamatergic neuron-targeted loss of Lgi1 causes a severe epileptic phenotype; Lgi1 displays an essential role in brain during the whole life.

  6. Lgi1 contains nuclear localization signal that mediates Lgi1 localization to cytoplasm and nucleus in CNS embryonic neurons.

  7. This study demonistrated that LGI1 plays a critical role in both dendritic and axonal pruning, we identify a novel molecular pathway in synapse and circuit remodeling.

  8. Lgi1 may have a role in establishing normal brain architecture and neuronal functions during brain development suggesting that it may be involved in neurogenesis and neuronal plasticity

  9. LGI1(+/-) and LGI1(-/-) mice may provide useful models for lateral temporal lobe epilepsy, and more generally idiopathic focal epilepsy.

  10. Lgi1 null mutant mice exhibit myoclonic seizures and CA1 (show CA1 ELISA Kits) neuronal hyperexcitability.

Leucine-Rich, Glioma Inactivated 1 (LGI1) Antigen Profile

Antigen Summary

This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy.

Gene names and symbols associated with LGI1

  • leucine rich glioma inactivated 1 (LGI1) antibody
  • leucine-rich repeat LGI family, member 1 (Lgi1) antibody
  • leucine-rich, glioma inactivated 1 (Lgi1) antibody
  • leucine-rich, glioma inactivated 1 (LGI1) antibody
  • leucine-rich, glioma inactivated 1 (lgi1) antibody
  • leucine rich glioma inactivated 1 (Lgi1) antibody
  • ADLTE antibody
  • ADPAEF antibody
  • ADPEAF antibody
  • BB130740 antibody
  • EPITEMPIN antibody
  • EPT antibody
  • ETL1 antibody
  • IB1099 antibody
  • MGC146600 antibody

Protein level used designations for LGI1

epitempin-1 , leucine-rich glioma-inactivated protein 1 , leucine-rich, glioma inactivated 1 , leucine-rich repeat LGI family, member 1 , putative leucine-rich glioma inactivated 1 , polymorphic marker clone YB07 , leucine-rich glioma-inactivated protein 1-like

GENE ID SPECIES
9211 Homo sapiens
56839 Mus musculus
252892 Rattus norvegicus
423802 Gallus gallus
450619 Pan troglodytes
477777 Canis lupus familiaris
617080 Bos taurus
700520 Macaca mulatta
779819 Xenopus (Silurana) tropicalis
100172937 Pongo abelii
100219007 Taeniopygia guttata
100415038 Callithrix jacchus
100597927 Nomascus leucogenys
100726518 Cavia porcellus
100344253 Oryctolagus cuniculus
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