Leucine-Rich, Glioma Inactivated 1 (LGI1) ELISA Kits

LGI1 is rearranged as a result of translocations in glioblastoma cell lines. Additionally we are shipping Leucine-Rich, Glioma Inactivated 1 Antibodies (130) and Leucine-Rich, Glioma Inactivated 1 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
LGI1 9211 O95970
LGI1 56839 Q9JIA1
LGI1 252892 Q8K4Y5
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Top Leucine-Rich, Glioma Inactivated 1 ELISA Kits at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.039 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$910.56
Details
Mouse 7.81 pg/mL 31.25-2000 pg/mL   96 Tests Log in to see 15 to 18 Days
$910.56
Details
Rat 0.08 ng/mL n/a   96 Tests Log in to see 15 to 18 Days
$910.56
Details

More ELISA Kits for Leucine-Rich, Glioma Inactivated 1 Interaction Partners

Human Leucine-Rich, Glioma Inactivated 1 (LGI1) interaction partners

  1. the LGI1-ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission

  2. The data obtained strongly suggest the possibility of gene LGL1 inactivation by epigenetic mechanism: modified <>.

  3. The clinical phenotypes of anti-LGI1 encephalitis and anti-Caspr2 encephalitis have been described in more detail including data on treatment and long-term follow-up. Lumping patients with anti-LGI1, anti-Caspr2 antibodies or lacking both, should be considered obsolete--{REVIEW}

  4. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy

  5. Autosomal dominant epilepsy with auditory features family due to a novel LGI1 mutation.

  6. Clinical analysis of a lateral temporal lobe epilepsy cohort from Turkey and genetic contribution of LGI1 to autosomal dominant lateral temporal lobe epilepsy phenotype

  7. Report of three novel LGI1 mutations, a microdeletion of exon 2 and two missense mutations in exon 8, occurring in two autosomal dominant lateral temporal epilepsy families and in one sporadic patient with lateral temporal epilepsy

  8. study found no cryptic imbalances were in LGI1 in partial epilepsy with auditory features (PEAF) patients, suggesting that LGI1 microdeletions are not a frequent cause of PEAF

  9. The Multiplex ligation-dependent probe amplifications analysis did not reveal any pathogenic changes in the LGI1 gene. Chromosomal rearrangements involving the LGI1 gene were not identified in our series of familial or sporadic LTE.

  10. A new LGI1 missense mutation is identified in a large Korean family with autosomal dominant lateral temporal lobe epilepsy.

  11. Seven LGI1-affected individuals report auditory aura and one visual aura; three families with autosomal dominant epilepsy and auditory features have novel LGI1 mutations.

  12. Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma.

  13. This study expands the phenotypic spectrum associated with Autosomal dominant lateral temporal lobe epilepsy due to LGI1 mutation and underlines the need for more systematic evaluation of Attention-deficit hyperactivity disorder and related symptoms.

  14. The LGI1-ADAM22 interaction is neutralized by autoantibodies to epilepsy-related LGI1 in limbic encephalitis.

  15. This study demonistrated that Low penetrance of autosomal dominant lateral temporal epilepsy in Italian families without LGI1 mutations.

  16. Cerebrocortical manifestations are recorded in 76% of patients with LGI1 immunoglobulin G (IgG) seropositivity.

  17. Antibodies bind to proteins complexed with voltage-gated potassium channel (VGKC) complex in two patients with LG11-antibody encephalitis.

  18. This is the first microdeletion affecting LGI1 identified in autosomal dominant lateral temporal epilepsy.

  19. The N-terminal leucine-rich repeat region of the LGI1 gene is likely to play a major role in pathogenesis of autosomal dominant partial epilepsy with auditory features.

  20. LGI1, a secreted synaptic protein mutated to cause human partial epilepsy, regulates a seizure-induced circuit response by redistributing Kv4.2 channels to the neuronal surface in a transgenic mouse model.

Mouse (Murine) Leucine-Rich, Glioma Inactivated 1 (LGI1) interaction partners

  1. LGI1 is expressed at the axonal initial segment and regulates action potential firing by setting the density of the axonal Kv1.1 channels.

  2. LGI1 has a role in regulating cortical development, which is increasingly becoming recognized as one of the causes of idiopathic epilepsy.

  3. LGI1 and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95

  4. Review article demonstrating that LGI1 may be an essential player in the development of the brain

  5. Glutamatergic neuron-targeted loss of Lgi1 causes a severe epileptic phenotype; Lgi1 displays an essential role in brain during the whole life.

  6. Lgi1 contains nuclear localization signal that mediates Lgi1 localization to cytoplasm and nucleus in CNS embryonic neurons.

  7. This study demonistrated that LGI1 plays a critical role in both dendritic and axonal pruning, we identify a novel molecular pathway in synapse and circuit remodeling.

  8. Lgi1 may have a role in establishing normal brain architecture and neuronal functions during brain development suggesting that it may be involved in neurogenesis and neuronal plasticity

  9. LGI1(+/-) and LGI1(-/-) mice may provide useful models for lateral temporal lobe epilepsy, and more generally idiopathic focal epilepsy.

  10. Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability.

  11. in the brain of C57BL/6J adult mice by in situ hybridization. We found that the LGI1 transcript is mainly expressed in the dentate gyrus and CA3 field of the hippocampus.

  12. Reduce levels of secreted LGI1 is associated with autosomal dominant partial epilepsy with auditory features

  13. Two protein isoforms encoded by LGI1/epitempin are differentially expressed in mouse brain: the 60-kDa form is detected in the microsomal fraction, while the 65-kDa product is found in the cytosolic fraction.

  14. This study was the first to determine a specific profile of Lgi1 gene expression during central nervous system development, which suggests a possible inhibitory function in latter stages of development.

  15. study identified LGI1 as a specific binding partner of ADAM22 protein from mouse brain, and demonstrated the specific interaction between LGI1 and ADAM22

  16. The normal postnatal maturation of presynaptric and postsynaptic functions was arrested by the 835delC mutant Lgi1.

Zebrafish Leucine-Rich, Glioma Inactivated 1 (LGI1) interaction partners

  1. Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype.

Leucine-Rich, Glioma Inactivated 1 (LGI1) Antigen Profile

Antigen Summary

This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy.

Gene names and symbols associated with LGI1

  • leucine rich glioma inactivated 1 (LGI1) antibody
  • leucine-rich repeat LGI family, member 1 (Lgi1) antibody
  • leucine-rich, glioma inactivated 1 (Lgi1) antibody
  • leucine-rich, glioma inactivated 1 (LGI1) antibody
  • leucine-rich, glioma inactivated 1 (lgi1) antibody
  • leucine rich glioma inactivated 1 (Lgi1) antibody
  • leucine-rich, glioma inactivated 1a (lgi1a) antibody
  • ADLTE antibody
  • ADPAEF antibody
  • ADPEAF antibody
  • BB130740 antibody
  • EPITEMPIN antibody
  • EPT antibody
  • ETL1 antibody
  • fb78h12 antibody
  • IB1099 antibody
  • LGIa antibody
  • MGC146600 antibody
  • wu:fb78h12 antibody
  • zgc:65886 antibody

Protein level used designations for LGI1

epitempin-1 , leucine-rich glioma-inactivated protein 1 , leucine-rich, glioma inactivated 1 , leucine-rich repeat LGI family, member 1 , putative leucine-rich glioma inactivated 1 , polymorphic marker clone YB07 , leucine-rich glioma-inactivated protein 1-like , leucine-rich, glioma inactivated 1a

GENE ID SPECIES
9211 Homo sapiens
56839 Mus musculus
252892 Rattus norvegicus
423802 Gallus gallus
450619 Pan troglodytes
477777 Canis lupus familiaris
617080 Bos taurus
700520 Macaca mulatta
779819 Xenopus (Silurana) tropicalis
100172937 Pongo abelii
100219007 Taeniopygia guttata
100415038 Callithrix jacchus
100597927 Nomascus leucogenys
100726518 Cavia porcellus
323011 Danio rerio
100344253 Oryctolagus cuniculus
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