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May participate in the regulation of neuronal exocytosis (By similarity). Additionally we are shipping Leucine-Rich Repeat LGI Family, Member 3 Antibodies (61) and Leucine-Rich Repeat LGI Family, Member 3 Proteins (6) and many more products for this protein.
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Mouse (Murine) LGI3 ELISA Kit for Sandwich ELISA - ABIN817388
Kim, Kwon, Baek, Kim, Yun: Leucine-rich glioma inactivated 3 associates negatively with adiponectin. in Cytokine 2013
The expression of LGI3 was significantly associated with the prognosis of brain, colorectal and lung cancer.
LGI3 was mostly expressed in the granular layer of the epidermis of human skin.
Taken together, these results support the critical involvement of LGI3 in the cytokine network by interplaying with multiple adipokines, cytokines and signaling proteins.
findings show LGI3 and TNF-alpha (show TNF ELISA Kits) upregulated each other in 3T3-L1 cells; study suggests LGI3 is a pro-inflammatory adipokine and forms a positive feedback loop with TNF-alpha (show TNF ELISA Kits); propose that LGI3 is a member of adipokine network that plays regulatory roles in obesity-associated adipose tissue inflammation
results suggested that LGI3 may participate in adipose tissue homeostasis by negatively regulating adiponectin
Data suggest that leucine-rich glioma inactivated 3 (LGI3) may be a candidate adipokine that is perturbed in obesity and suppresses adipogenesis through its receptor, ADAM23 (show Adam23 ELISA Kits).
LGI3 interacts with Flo1 in the brain, and LGI3/Flo1 mediates APP (show APP ELISA Kits) trafficking and exosome formation in neuronal cells: reveals the details of the intracellular transport system and even the secretion pathway in the brain.
we propose that LGI3 is a neuritogenic factor whose signaling pathway involves Akt (show AKT1 ELISA Kits)-mediated FAK (show PTK2 ELISA Kits) activation.
LGI3 gene widespread expression in the brain suggests that its transcripts might be involved in a common cellular process present in different neuronal types.
The expression of mouse LGI3 (mLGI3) in adult and developing brain and analyzed the 5'-upstream transcriptional regulatory regions of mLGI3 gene.
Data show that LGI3 localizes to the endocytic pathway and its accumulation is caused by endocytic perturbation.
LGI3 may play a regulatory role in neuronal exocytosis via its interaction with syntaxin 1 (show STX1A ELISA Kits).
May participate in the regulation of neuronal exocytosis (By similarity).
leucine-rich repeat LGI family member 3
, LGI1-like protein 4
, leucine-rich glioma-inactivated protein 3
, putative leucine-rich glioma inactivated 3