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human homolog is thought to be linked to idiopathic generalized epilepsy. Additionally we are shipping and and many more products for this protein.
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Our results identify a new mechanism regulating enteric gliogenesis as well as novel functions for Lgi4 regulating the proliferation and maturation of glial lineage cells throughout the peripheral nervous system
lGI4 distribution in the vertical limb of the diagonal band and in putative hippocampal interneurons suggests that the function of these genes might be related to the generation of hippocampal theta rhythm.
Fxyd3 (show FXYD3 Antibodies) and Lgi4 transcripts potentially form double-stranded RNA molecules in many cell types in vivo, which may impact on their respective expression
the abnormalities observed in claw paw mice are attributable to the loss of Lgi4 function
in four unrelated multiplex families presenting with severe arthrogryposis multiplex congenital, identified biallelic loss-of-function mutations in LGI4; functional tests showed these germline mutations caused aberrant splicing of the endogenous LGI4 transcript and in a cell-based assay impaired the secretion of truncated LGI4 protein
Intratumoral heterogeneity of ADAM23 (show Adam23 Antibodies) promotes tumor growth and metastasis through LGI4 and nitric oxide signals.
The positive genotypic association between benign familial infantile convulsions (BFIC)and c.1722G/A polymorphism suggests that LGI4 might contribute to the susceptibility to BFIC.
Schwann cells are the principal cellular source of Lgi4 in the developing nerve; transgenic Lgi4 binds directly to Adam22 (show ADAM22 Antibodies) without a requirement for additional membrane associated factors.
Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE (show GJA8 Antibodies)) revealed several frequent exonic polymorphisms.
has seven copies of the EPTP repeat, a unifying protein sequence motif of a heterogenous group of proteins linked to epileptic diseases. The EPTP repeat probably forms a beta (show SUCLA2 Antibodies)-propeller structure.
human homolog is thought to be linked to idiopathic generalized epilepsy
leucine-rich repeat LGI family, member 4
, leucine-rich repeat LGI family member 4
, leucine-rich glioma inactivated protein 4
, leucine-rich repeat LGI family member 4-like
, LGI1-like protein 3
, leucine-rich glioma-inactivated protein 4
, leucine-rich glioma-inactivated gene 4