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this study shows that CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT cells with Kupffer cells
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Antigen targeting to DEC-205 on dendritic cells leads to an IL-10-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 cells in vivo. This downregulation interferes with the migration of Th1 cells into the gut and protects mice against severe acute and relapsing intestinal inflammation.
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DNA vaccines encoding DEC205-targeted antigens induce peripheral tolerance rather than immunity
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The DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1.
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Through analysis of both polyclonal and monoclonal transgenic TCR T-cell development in the context of CD205 deficiency, we demonstrate that CD205 does not play an overt role in T cell development or selection.
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Introduction of a labile dipeptide linker at the N terminus of a T-cell epitope improves proteasome-dependent class I MHC-restricted peptide cross-presentation when delivered by alphaDEC205 in vitro and in vivo.
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Data indicate that the interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of the PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface.
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CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo
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Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation.
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For production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants.
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Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.
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show that Flt3L DC efficiently crosspresent HIV gag via the DEC-205 receptor, about 100 times more effective than non-targeted gag.
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Results suggest that DEC-205 provides an efficient receptor-based mechanism for dendritic cells to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after dendritic cell maturation.
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This protein was detected in mouse Langerhans cells on epidermis separated by microwave irradiation.
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Dendritic cell targeting via the DEC205 receptor in the presence of anti-CD40 and poly(I:C) as maturation stimuli, induced strong human and mouse survivin-specific CD4+ T cell responses
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murine DEC-205 is a receptor for PLA of Yersinia pestis
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CD205 acts as a recognition receptor for dying cells, potentially providing an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance.
