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Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity).
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this study shows that CD205-TLR9 (show TLR9 Proteins)-IL-12 (show IL12A Proteins) axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT (show CTSL1 Proteins) cells with Kupffer cells
Antigen targeting to DEC-205 on dendritic cells leads to an IL-10 (show IL10 Proteins)-dependent downregulation of CXCR3 (show CXCR3 Proteins) expression on differentiated antigen-specific Th1 (show HAND1 Proteins) cells in vivo. This downregulation interferes with the migration of Th1 (show HAND1 Proteins) cells into the gut (show GUSB Proteins) and protects mice against severe acute and relapsing intestinal inflammation.
DNA vaccines encoding DEC205-targeted antigens induce peripheral tolerance rather than immunity
The DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 (show CD8A Proteins) T cells independently of PD-1 (show PDCD1 Proteins) and PD-L1 (show CD274 Proteins).
Through analysis of both polyclonal and monoclonal transgenic TCR T-cell development in the context of CD205 deficiency, we demonstrate that CD205 does not play an overt role in T cell development or selection.
Introduction of a labile dipeptide linker at the N terminus of a T-cell epitope improves proteasome-dependent class I MHC-restricted peptide cross-presentation when delivered by alphaDEC205 in vitro and in vivo.
Data indicate that the interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of the PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface.
CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo
Langerin (show CD207 Proteins)-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation.
For production of cytotoxic T cells, DEC-205 and Clec9A (show CLEC9A Proteins), but not Clec12A (show CLEC12A Proteins), are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants.
keratins are the cellular ligands of human DEC205.
High LY75 expression is associated with metastasis of ovarian cancer.
IL-6 (show IL6 Proteins), DEC205, and CD86 (show CD86 Proteins) can be predictive biomarkers for the respiratory and immune effects of ambient PM2.5.
LY75 Gene Polymorphisms are Associated with Inflammatory Bowel Disease.
results suggest that DEC205 is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism
Variants in LY75 were associated with a Crohn's disease phenotype involving erythema nodosum.
DEC-205 is a cell surface receptor for CpG olligonucleotides.
The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein (show PITPNA Proteins), cytoplasmic 1 gene.
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
lymphocyte antigen 75
, DEC-205/CD205 protein
, CD205 protein
, DEC-205 protein
, Lymphocyte antigen 75
, lymphocyte antigen 75-like
, C-type lectin domain family 13 member B