Lymphocyte Antigen 75 Proteins (LY75)

Mouse (Murine) Lymphocyte Antigen 75 (LY75) interaction partners

1. this study shows that CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT cells with Kupffer cells

2. Antigen targeting to DEC-205 on dendritic cells leads to an IL-10-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 cells in vivo. This downregulation interferes with the migration of Th1 cells into the gut and protects mice against severe acute and relapsing intestinal inflammation.

3. DNA vaccines encoding DEC205-targeted antigens induce peripheral tolerance rather than immunity

4. The DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1.

5. Through analysis of both polyclonal and monoclonal transgenic TCR T-cell development in the context of CD205 deficiency, we demonstrate that CD205 does not play an overt role in T cell development or selection.

6. Introduction of a labile dipeptide linker at the N terminus of a T-cell epitope improves proteasome-dependent class I MHC-restricted peptide cross-presentation when delivered by alphaDEC205 in vitro and in vivo.

7. Data indicate that the interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of the PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface.

8. CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo

9. Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation.

10. For production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants.

11. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.

12. show that Flt3L DC efficiently crosspresent HIV gag via the DEC-205 receptor, about 100 times more effective than non-targeted gag.

13. Results suggest that DEC-205 provides an efficient receptor-based mechanism for dendritic cells to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after dendritic cell maturation.

14. This protein was detected in mouse Langerhans cells on epidermis separated by microwave irradiation.

15. Dendritic cell targeting via the DEC205 receptor in the presence of anti-CD40 and poly(I:C) as maturation stimuli, induced strong human and mouse survivin-specific CD4+ T cell responses

16. murine DEC-205 is a receptor for PLA of Yersinia pestis

17. CD205 acts as a recognition receptor for dying cells, potentially providing an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance.

Human Lymphocyte Antigen 75 (LY75) interaction partners

1. combined panel had the highest sensitivity and specificity at 96.3% and 100%, which was significantly or marginally higher than those of EZH2, C-KIT, and CD205 alone

2. keratins are the cellular ligands of human DEC205.

3. High LY75 expression is associated with metastasis of ovarian cancer.

4. IL-6, DEC205, and CD86 can be predictive biomarkers for the respiratory and immune effects of ambient PM2.5.

5. LY75 Gene Polymorphisms are Associated with Inflammatory Bowel Disease.

6. results suggest that DEC205 is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism

7. Variants in LY75 were associated with a Crohn's disease phenotype involving erythema nodosum.

8. elevated in cholesteatoma

9. DEC-205 is a cell surface receptor for CpG olligonucleotides.

10. Data indicate that the interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of the PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface.

11. The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene.

12. CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo

13. Upregulation of LY75 is associated with ovarian tumor.

14. observed that TLR-mediated signaling increases DEC-205 expression levels without affecting receptor internalization

15. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1

16. DCs and DEC-205 can cross-present several different peptides from a single protein. Data supports testing of alphaDEC-205 fusion mAb as a protein-based vaccine.

17. CD205 is a sensitive and specific marker for thymoma but its sensitivity to thymic carcinoma is lower than CD5 and CD117.

18. targeting EBV nuclear antigen 1 to human DEC-205 receptor, in the presence of the DC maturation stimulus poly(I:C), expanded EBNA1-specific CD4 and CD8 memory T cells; these lymphocytes control the outgrowth of autologous EBV-infected B cells

19. oxLDL uptake by DCs is mediated by the scavenger-receptors LOX-1, CD36, and CD205

20. Induction of LY75 antigen is associated with relapsed chronic myeloid leukemia.