anti-Lysine (K)-Specific Demethylase 2A (KDM2A) Antibodies

KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping KDM2A Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KDM2A 225876 P59997
KDM2A 361700  
KDM2A 22992 Q9Y2K7
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Top anti-KDM2A Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Human Muscle WB Suggested Anti-FBXL11 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: KDM2A/FBXL11 Antibody [ABIN2616792] - FFPE section of human skin basal cell carcinoma. Affinity purified rabbit anti-JHDM1A used at a dilution of 1:250. 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human testis tissue reacted with JHDM1a/FBXL11 antibody (Center) (ABIN387896), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of JHDM1a/FBXL11 (arrow) using rabbit polyclonal JHDM1a/FBXL11 Antibody (Center)(ABIN387896).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the JHDM1a/FBXL11 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of JHDM1a/FBXL11 Antibody (N-term) (ABIN387895) in T47D cell line lysates (35 µg/lane). FBXL11 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of JHDM1a/FBXL11 (arrow) using rabbit polyclonal JHDM1a/FBXL11 Antibody (N-term) (ABIN387895).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the JHDM1a/FBXL11 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Bat Goat Un-conjugated ELISA, IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-JHDM1a/FBXL11 Antibody (C-term)  pre-incubated with(right lane) and without(left lane) blocking peptide in Jurkat cell line lysate. JHDM1a(arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
$385.00
Details

Top referenced anti-KDM2A Antibodies

  1. Human Polyclonal KDM2A Primary Antibody for ICC, IF - ABIN261679 : Wagner, Alam, Dhar, Giri, Li, Wei, Giri, Cascone, Kim, Ye, Multani, Chan, Erez, Saigal, Chung, Lin, Wu, Hung, Heymach, Lee: KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. in The Journal of clinical investigation 2013 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal KDM2A Primary Antibody for IHC (p), ELISA - ABIN543184 : Tsukada, Fang, Erdjument-Bromage, Warren, Borchers, Tempst, Zhang: Histone demethylation by a family of JmjC domain-containing proteins. in Nature 2006 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal KDM2A Primary Antibody for ELISA, WB - ABIN4328581 : Nagase, Ishikawa, Suyama, Kikuno, Hirosawa, Miyajima, Tanaka, Kotani, Nomura, Ohara: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. in DNA research : an international journal for rapid publication of reports on genes and genomes 1999 (PubMed)

More Antibodies against KDM2A Interaction Partners

Pig (Porcine) Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. JHDM1A is differentially expressed in porcine embryonic skeletal muscle and associated with meat growth and quality traits.

Mouse (Murine) Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. Kdm2a expression may be closely related to cell proliferation

  2. Fbxl11 plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival.

  3. we identify Jhdm1a negatively regulates gluconeogenic gene PEPCK and G6Pase expression both in vitro and in vivo

  4. Data describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of p65, carried out by nuclear receptor-binding SET domain-containing protein 1 (NSD1) and F-box and leucine-rich repeat protein 11 (FBXL11).

Human Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. KDM2A-SF forms distinct nuclear heterochromatic bodies in an HP1a dependent manner

  2. Authors conclude that KDM2A functions as an oncogene in breast cancer by upregulating JAG1 to promote stemness, chemoresistance and angiogenesis.

  3. Identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (HP1) interaction motif that mediates direct binding between KDM2A and HP1. This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.

  4. The miR-29b/KDM2A axis was involved in the RUNX3-mediated inhibition of gastric cancer cell proliferation and metastasis.

  5. KDM2A-WWTR1 fusion is associated with ossifying fibromyxoid tumors.

  6. Silencing KDM2A, a histone demethylase and BCL6 co-repressor, de-repressed SFRP2 transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 promoter.

  7. Findings suggest that amplification and overexpression of the KDM2A short isoform is critical in breast cancer progression.

  8. In this study, KDM2A was identified as a novel substrate of ATM. DSB enhanced the interaction between ATM and KDM2A, which induced ATM-mediated phosphorylation of KDM2A at T632.

  9. The results suggest that under mild glucose starvation AMP-activated kinase induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation.

  10. FBXL11 is proposed as a novel component of the circadian clock that regulates the circadian gene expression by a so far unknown mechanism.

  11. The protein lysine demethylases Kdm2a and Kdm2b regulate the turnover of non-phosphorylated beta-catenin specifically within the nucleus via direct interaction with the fourth and fifth armadillo repeats.

  12. Upregulation of KDM2A is very important in the progression of gastric cancer.

  13. a regulatory role for KDM2A in breast cancer cell invasion and migration, through the regulation of E2F1 function

  14. KDM2A binds to the rDNA promoter with unmethylated CpG sequences via the CxxC-ZF domain

  15. KDM2A represses histone deacetylase 3 and has a role in tumorigenicity of lung cancer cells

  16. KDMA2 is frequently overexpressed in NSCLC tumors & cell lines. It is needed for in vitro proliferation & invasion. KDM2A activated ERK1/2 by epigenetic repression of DUSP3 expression via demethylation of dimethylated H3K36 at the DUSP3 locus.

  17. KDM2A is a H3K4 demethylase that regulates cell proliferation through p15(INK4B) and p27(Kip1) in stem cells from apical papilla.

  18. FBXL11 inhibited osteo/dentinogenic differentiation potential in MSC cells by associating with BCOR, then increasing histone K4/36 methylation in Epiregulin promoter to repress Epiregulin transcription.

  19. results not only show that differently spliced transcripts from a gene result in totally opposite outcomes, but also present critical evidence of the complicated activities of KDM2A, which contains all of the five domains

  20. The oncometabolite 2-hydroxyglutarate is a competitive inhibitor of multiple alpha-ketoglutarate-dependent dioxygenases, including histone demethylases, prolyl hydroxylases, and the TET family of 5-methlycytosine hydroxylases.

Zebrafish Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. loss of the orthologue kdm2aa in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanomas at a high frequency

KDM2A Antigen Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KDM2A

  • lysine demethylase 2A (KDM2A) antibody
  • lysine (K)-specific demethylase 2A (Kdm2a) antibody
  • lysine demethylase 2A (Kdm2a) antibody
  • lysine (K)-specific demethylase 2Aa (kdm2aa) antibody
  • 5530401A10Rik antibody
  • 100043628 antibody
  • AA589516 antibody
  • AW536790 antibody
  • CXXC8 antibody
  • fb76b11 antibody
  • FBL7 antibody
  • FBL11 antibody
  • Fbxl11 antibody
  • Gm4560 antibody
  • Jhdm1 antibody
  • Jhdm1a antibody
  • KDM2A antibody
  • lalina antibody
  • LILINA antibody
  • wu:fb76b11 antibody
  • wu:fj11c04 antibody
  • zgc:158441 antibody
  • zgc:158606 antibody

Protein level used designations for KDM2A

F-box and leucine-rich repeat protein 11 , jumonji C domain-containing histone demethylase 1A , lysine-specific demethylase 2A , F-box protein containing leucine repeats , F-box/LRR-repeat protein 11 , [Histone-H3]-lysine-36 demethylase 1A , jmjC domain-containing histone demethylation protein 1A , lysine (K)-specific demethylase 2A , CXXC-type zinc finger protein 8 , JmjC domain-containing histone demethylation protein 1B , lysine (K)-specific demethylase 2B

GENE ID SPECIES
100294703 Sus scrofa
540141 Bos taurus
225876 Mus musculus
483702 Canis lupus familiaris
361700 Rattus norvegicus
22992 Homo sapiens
571851 Danio rerio
100052955 Equus caballus
100732285 Cavia porcellus
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