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KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping KDM2A Proteins (3) and and many more products for this protein.
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Human Polyclonal KDM2A Primary Antibody for ICC, IF - ABIN261679
Wagner, Alam, Dhar, Giri, Li, Wei, Giri, Cascone, Kim, Ye, Multani, Chan, Erez, Saigal, Chung, Lin, Wu, Hung, Heymach, Lee: KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. in The Journal of clinical investigation 2013
Show all 2 Pubmed References
Human Polyclonal KDM2A Primary Antibody for ELISA, WB - ABIN4328581
Nagase, Ishikawa, Suyama, Kikuno, Hirosawa, Miyajima, Tanaka, Kotani, Nomura, Ohara: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. in DNA research : an international journal for rapid publication of reports on genes and genomes 1999
JHDM1A is differentially expressed in porcine embryonic skeletal muscle and associated with meat growth and quality traits.
Kdm2a (show KDM3A Antibodies) expression may be closely related to cell proliferation
Fbxl11 plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival.
we identify Jhdm1a negatively regulates gluconeogenic gene PEPCK (show PEPCK Antibodies) and G6Pase (show G6PC Antibodies) expression both in vitro and in vivo
Data describe a NF-kappaB (show NFKB1 Antibodies) regulatory pathway that is driven by reversible lysine methylation of p65 (show NFkBP65 Antibodies), carried out by nuclear receptor-binding SET domain-containing protein 1 (NSD1 (show NSD1 Antibodies)) and F-box and leucine-rich repeat protein 11 (FBXL11).
KDM2A-SF forms distinct nuclear heterochromatic bodies in an HP1a (show TFF1 Antibodies) dependent manner
Authors conclude that KDM2A functions as an oncogene (show RAB1A Antibodies) in breast cancer by upregulating JAG1 (show JAG1 Antibodies) to promote stemness, chemoresistance and angiogenesis.
Identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD (show PDC Antibodies) domain and a newly identified Heterochromatin Protein 1 (HP1 (show DEFA1 Antibodies)) interaction motif that mediates direct binding between KDM2A and HP1 (show DEFA1 Antibodies). This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.
The miR (show MLXIP Antibodies)-29b/KDM2A axis was involved in the RUNX3 (show RUNX3 Antibodies)-mediated inhibition of gastric cancer cell proliferation and metastasis.
KDM2A-WWTR1 (show WWTR1 Antibodies) fusion is associated with ossifying fibromyxoid tumors.
Silencing KDM2A, a histone demethylase (show MBD2 Antibodies) and BCL6 co-repressor (show BCOR Antibodies), de-repressed SFRP2 (show SFRP2 Antibodies) transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 (show SFRP2 Antibodies) promoter.
Findings suggest that amplification and overexpression of the KDM2A short isoform is critical in breast cancer progression.
In this study, KDM2A was identified as a novel substrate of ATM (show ATM Antibodies). DSB enhanced the interaction between ATM (show ATM Antibodies) and KDM2A, which induced ATM (show ATM Antibodies)-mediated phosphorylation of KDM2A at T632.
The results suggest that under mild glucose starvation AMP (show APRT Antibodies)-activated kinase induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation.
FBXL11 is proposed as a novel component of the circadian clock that regulates the circadian gene expression by a so far unknown mechanism.
loss of the orthologue kdm2aa (show KDM2B Antibodies) in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanomas at a high frequency
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
F-box and leucine-rich repeat protein 11
, jumonji C domain-containing histone demethylase 1A
, lysine-specific demethylase 2A
, F-box protein containing leucine repeats
, F-box/LRR-repeat protein 11
, [Histone-H3]-lysine-36 demethylase 1A
, jmjC domain-containing histone demethylation protein 1A
, lysine (K)-specific demethylase 2A
, CXXC-type zinc finger protein 8
, JmjC domain-containing histone demethylation protein 1B
, lysine (K)-specific demethylase 2B