Lysine (K)-Specific Demethylase 5B Proteins (KDM5B)

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Additionally we are shipping KDM5B Antibodies (133) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM5B 10765 Q9UGL1
KDM5B 75605 Q80Y84
Rat KDM5B KDM5B 304809  
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Top KDM5B Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Insect cells (Sf9) Human DYKDDDDK Tag JARID1B / KDM5B activity assay. Recombinant JARID1B / KDM5B activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JARID1B / KDM5B enzymatic assay. Demethylase activity of JARID1B / KDM5B was measured with an enzymatic assay. MALDI-TOF was used for detection. Catalytic rate: 20 turnovers/enzyme/hour. 20 μg Log in to see 1 to 2 Days

KDM5B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 5B (KDM5B) Interaction Partners

Human Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. JARID1B directly bound to PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling inhibitor SHIP1 (show INPP5D Proteins) gene promoter and decreased SHIP1 (show INPP5D Proteins) gene expression.

  2. We established the function of JARID1B in mediating the cancer stem cell potential of G0-like cells and our results expand understanding of its context-specific roles in malignant and normal stem cell homeostasis

  3. KDM5B is up-regulated in esophageal squamous cell carcinoma cells.MiR-194 targets KDM5B to inhibit esophageal squamous cell carcinoma development and progression.

  4. Study identified USP15 (show USP15 Proteins) as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 (show FOXP1 Proteins) and KDM5B).

  5. research suggests that miR424-5p may act as a novel anti-oncogene (show RAB1A Proteins) in cervical cancer by blocking cell growth through targeting KDM5B-Notch (show NOTCH1 Proteins) pathway

  6. JARID1B is involved in the pathogenesis of glioma.

  7. PLU-1 was overexpressed in colorectal cancer tissue compared with healthy colon. PLU-1 expression positively correlated with colorectal cancer progression.

  8. Hsa-miR-448 disrupting KDM5B-MALAT1 signalling axis and associated activities in TNBC cells, projects it as a putative therapeutic factor for selective eradication of TNBC cells.

  9. data indicate that parallel immunohistochemical assays of the expression levels of all the isoforms and of the RBP2-H1 variant of JARID1B may be an efficient technique of differentiating between benign naevi and melanomas

  10. KDM5B, a histone demethylase (show MBD2 Proteins) known to be involved in breast cancer tumorigenesis, as a target of miR (show MLXIP Proteins)-137.

Mouse (Murine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. KDM5B, which demethylates H3K4me3, plays an integral role in regulating RNAPII occupancy, transcriptional initiation and elongation, and alternative splicing events in embryonic stem cells.

  2. data suggest Kdm5b negatively regulates neurogenesis and represses reelin (show RELN Proteins) in neural stem cells from the adult subventricular zone.

  3. These results suggest that KDM5B acts to repress type I IFN and other innate cytokines to promote an altered immune response following Respiratory syncytial virus infection that contributes to development of chronic disease.

  4. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR

  5. Deletion of Jarid1b compromises hematopoietic stem cell (HSC (show FUT1 Proteins)) self-renewal capacity; Jarid1b is a positive regulator of HSC (show FUT1 Proteins) potential.

  6. Mechanistically, JARID1B was required for GATA3 (show GATA3 Proteins) recruitment to the Foxa1 (show FOXA1 Proteins) promoter to activate Foxa1 (show FOXA1 Proteins) expression.

  7. KDM5B is a barrier to the reprogramming process as evidenced by the accelerated reprogramming of differentiated cells in the absence of Kdm5b.

  8. these studies identified Jarid1b as a negative regulator of hematopoietic stem cell (HSC (show FUT1 Proteins)) activity and Jhdmlf as a positive regulator of HSC (show FUT1 Proteins) activity.

  9. Results suggest a role for Jarid1b in Rb-mediated repression of cell cycle genes during senescence.

  10. results delineate an essential role for Jarid1b-mediated transcriptional control during embryonic stem cell differentiation

Cow (Bovine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. Histone demethylases KDM3A (show KDM3A Proteins), KDM4A (show KDM4A Proteins), and KDM4C (show KDM4C Proteins) were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period.

KDM5B Protein Profile

Protein Summary

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor (By similarity).

Gene names and symbols associated with KDM5B

  • lysine (K)-specific demethylase 5Ba (kdm5ba)
  • lysine (K)-specific demethylase 5Bb (kdm5bb)
  • lysine demethylase 5B (KDM5B)
  • lysine (K)-specific demethylase 5B (Kdm5b)
  • lysine (K)-specific demethylase 5B (KDM5B)
  • lysine demethylase 5B (Kdm5b)
  • 2010009J12Rik protein
  • 2210016I17Rik protein
  • AW556288 protein
  • cb264 protein
  • CT31 protein
  • D1Ertd202e protein
  • id:ibd5050 protein
  • Jarid1b protein
  • jarid1ba protein
  • jarid1bb protein
  • mKIAA4034 protein
  • PLU-1 protein
  • Plu1 protein
  • PUT1 protein
  • Rb-Bp2 protein
  • RBBP2H1A protein
  • RGD1565602 protein
  • wu:fc44h11 protein
  • wu:fd15c05 protein
  • zgc:85741 protein

Protein level used designations for KDM5B

jumonji, AT rich interactive domain 1B (Rbp2 like) , jumonji, AT rich interactive domain 1Ba (Rbp2 like) , histone demethylase JARID1B-B , jumonji/ARID domain-containing protein 1B-B , lysine-specific demethylase 5B-B , putative DNA/chromatin binding motif , lysine (K)-specific demethylase 5B , Jumonji, AT rich interactive domain 1B (RBP2-like) , jumonji, AT rich interactive domain 1B , lysine-specific demethylase 5B-like , RBP2-H1 , cancer/testis antigen 31 , histone demethylase JARID1B , jumonji/ARID domain-containing protein 1B , lysine-specific demethylase 5B , retinoblastoma-binding protein 2 homolog 1 , retinoblastoma-binding protein 2, homolog 1A , putative DNA/chromatin binding motif 1

327168 Danio rerio
415256 Danio rerio
457630 Pan troglodytes
100011885 Monodelphis domestica
100064707 Equus caballus
100077577 Ornithorhynchus anatinus
100356218 Oryctolagus cuniculus
100483283 Ailuropoda melanoleuca
10765 Homo sapiens
75605 Mus musculus
421168 Gallus gallus
479999 Canis lupus familiaris
100625438 Sus scrofa
540633 Bos taurus
304809 Rattus norvegicus
100723111 Cavia porcellus
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