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Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Additionally we are shipping Kdm6b Antibodies (99) and and many more products for this protein.
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loss of both kdm6ba and kdm6bb shows Kdm6b proteins share redundant and pleiotropic roles in organogenesis without impacting initial cell fate specification.
Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (show CAD ELISA Kits) fin regeneration, and that Kdm6b.1 may be the histone demethylase (show MBD2 ELISA Kits) required during regeneration.
binding of SMAD2 (show SMAD2 ELISA Kits)/3, the intracellular effectors of activin (show Actbeta ELISA Kits) signaling, was significantly enriched at the Pmepa1 (show PMEPA1 ELISA Kits) gene, which encodes a negative feedback regulator of TGF-beta (show TGFB1 ELISA Kits) signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.
Results identified Kdm6b as a novel regulator of the pro-fibrotic signature of peritoneal foam cells.
These results suggest that the demethylase (show MBD2 ELISA Kits) activity of Jmjd3, but not that of Utx, affects mouse axial patterning in concert with alterations in Hox (show MSH2 ELISA Kits) gene expression.
Direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop.
Knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated osteoarthritis progression via inhibition of the anabolic metabolism of chondrocytes. The number of Kdm6b-positive chondrocytes was lower in osteoarthritis cartilage samples.
Preliminary evidence suggests a role of JMJD3 in removal of H3K27me3 mark from promoters of hepatic transcription factors, thus activating epigenetically poised hepatic genes in bone marrow progenitor cells prior to partial nuclear reprogramming.
Study provides evidence that miR (show MLXIP ELISA Kits)-148a-3p reciprocally regulates adipocyte and osteoblast differentiation through directly targeting Kdm6b.
the redox regulation of Jmjd3 is a unique regulatory mechanism for Cu,Zn-superoxide dismutase (show SOD1 ELISA Kits)-mediated profibrotic macrophage polarization.
our study has attributed novel roles for JMJD3 and its regulators during mycobacterial infection that assist foamy macrophage generation and fine-tune associated host immunity
ISL1 (show ISL1 ELISA Kits) and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation.
In this study, we showed that aberrantly upregulated JMJD3 exerts an anti-apoptotic effect in diffuse large B-cell lymphoma
Our study therefore delineates KDM6B function that links NF-kappaB (show NFKB1 ELISA Kits) and MAPK (show MAPK1 ELISA Kits) signaling pathway mediating MM cell growth and survival, and validates KDM6B as a novel therapeutic target in MM.
Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 (show STAT6 ELISA Kits) target gene CCL18 (show CCL18 ELISA Kits), while induction of other STAT6 (show STAT6 ELISA Kits)-inducible genes such as SPINT2 (show SPINT2 ELISA Kits) remained unaffected by JMJD3.
Here, we discuss the roles of lysine 27 demethylases, JMJD3 and UTX, in cancer and potential therapeutic avenues targeting these enzymes. Despite a high degree of sequence similarity in the catalytic domain between JMJD3 and UTX, numerous studies revealed surprisingly contrasting roles in cellular reprogramming and cancer, particularly leukemia
inhibition of the H3K27 demethylase (show MBD2 ELISA Kits) JMJD3 in naive CD4 (show CD4 ELISA Kits) T cells demonstrates how critically important molecules required for T cell differentiation, such as JAK2 (show JAK2 ELISA Kits) and IL12RB2 (show IL12RB2 ELISA Kits), are regulated by H3K27me3.
KDM6B expression strongly correlates with ERbeta (show ESR2 ELISA Kits) level in human pleural mesothelioma tumors and cell lines.
Low JMJD3 expression is associated with breast cancer.
results demonstrate that the regulation of Jmjd3 by STAT3 (show STAT3 ELISA Kits) maintains repression of differentiation specific genes and is therefore important for the maintenance of self-renewal of normal neural and glioblastoma stem cells
Data show that histone demethylase (show MBD2 ELISA Kits) JMJD3 was reduced and its target gene Snai1 (show SNAI1 ELISA Kits) expression was down-regulated after HOTAIR suppression.
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
jumonji domain containing 3
, lysine (K)-specific demethylase 6B
, jumonji domain containing 3, histone lysine demethylase
, lysine-specific demethylase 6B-like
, jmjC domain-containing protein 3
, jumonji domain-containing protein 3
, lysine-specific demethylase 6B
, lysine demethylase 6B
, jumonji domain-containing 3