Lysine (K)-Specific Demethylase 6B (Kdm6b) ELISA Kits

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Additionally we are shipping Kdm6b Antibodies (107) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse Kdm6b Kdm6b 216850 Q5NCY0
Kdm6b 23135 O15054
Anti-Rat Kdm6b Kdm6b 363630  
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human < 28 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Log in to see 11 to 18 Days
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  10 reactions Log in to see 4 to 6 Days

More ELISA Kits for Kdm6b Interaction Partners

Zebrafish Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. Data show that Spi1 is a downstream target of histone demethylase Jmjd3 (Jmjd3) during myelopoiesis.

  2. loss of both kdm6ba and kdm6bb shows Kdm6b proteins share redundant and pleiotropic roles in organogenesis without impacting initial cell fate specification.

  3. Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal fin regeneration, and that Kdm6b.1 may be the histone demethylase required during regeneration.

Mouse (Murine) Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. The present study suggested that JMJD3 was a critical promoter of neuronal apoptosis

  2. JMJD3 regulates fibroblast-like synoviocyte-mediated proliferation and joint destruction in rheumatoid arthritis.

  3. Mechanistic exploration identified a physical and functional association of JMJD3 with C/EBPbeta that presides the regulatory network of JMJD3.

  4. Our data show that chemical inhibition of the H3K27me3 demethylases Jmjd3/Utx blunts Neurogenin3-dependent gene activation in vitro. Conversely, inhibition of the H3K27me3 methyltransferase Ezh2 enhances both the transactivation ability of Neurogenin3 in cultured cells and the formation of insulin-producing cells during directed differentiation from pluripotent cells

  5. Study indicates sequential chromatin events and identifies a crucial role for Jmjd3 in regulating the efficiency of the transition from Ngn3-low to Ngn3-high cells.

  6. When JMJD3 levels were decreased by RNA interference, the embryo development rate and quality were improved, but the knockdown of UTX produced the opposite results.

  7. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.

  8. Results identified Kdm6b as a novel regulator of the pro-fibrotic signature of peritoneal foam cells.

  9. These results suggest that the demethylase activity of Jmjd3, but not that of Utx, affects mouse axial patterning in concert with alterations in Hox gene expression.

  10. Direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop.

  11. Knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated osteoarthritis progression via inhibition of the anabolic metabolism of chondrocytes. The number of Kdm6b-positive chondrocytes was lower in osteoarthritis cartilage samples.

  12. Preliminary evidence suggests a role of JMJD3 in removal of H3K27me3 mark from promoters of hepatic transcription factors, thus activating epigenetically poised hepatic genes in bone marrow progenitor cells prior to partial nuclear reprogramming.

  13. Study provides evidence that miR-148a-3p reciprocally regulates adipocyte and osteoblast differentiation through directly targeting Kdm6b.

  14. the redox regulation of Jmjd3 is a unique regulatory mechanism for Cu,Zn-superoxide dismutase-mediated profibrotic macrophage polarization.

  15. our study has attributed novel roles for JMJD3 and its regulators during mycobacterial infection that assist foamy macrophage generation and fine-tune associated host immunity

  16. ISL1 and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation.

  17. Histone H3 lysine-27 demethylase (H3K27me3 demethylase) activity would act as a negative regulator of dendritic cells (DCs).

  18. nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells

  19. differentiating embryonic stem cells (ESCs) depend on KDM6 and the H3K27me3 demethylase activity is crucially involved in DNA damage response and survival of differentiating ESCs.

  20. JMJD3 up-regulation and NF-kappaB activation occur in the region of the wound edge during keratinocyte wound healing

Human Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. JMJD3 are key regulators of cytokine production in human NK cell subsets.

  2. The authors found that Notch1 is up-regulated in the wound edge and its expression is dependent on JMJD3 and NF-kappaB in wounded keratinocytes.

  3. The KDM6B inhibitor GSK-J4 perturbed the PMA-mediated differentiation of THP-1 cells. The AURKA inhibitor alisertib accelerates the expression of the H3K27 demethylase KDM6B, dissociating AURKA and YY1 from the KDM6B promoter region and inducing differentiation.

  4. The interaction of methyltransferase EZH2 or demethylase JMJD3 on RGMA, RARb2, AR, PGR, and ERa genes in the progression and aggressiveness of prostate cancer.

  5. We demonstrate that extraskeletal osteosarcoma (ESOS) may include at least two small subsets: an MDM2-amplified deep soft-tissue ESOS and an H3K27me3-deficient organ-based ESOS

  6. Our results demonstrate that in the early stage of sepsis, JMJD3 contributes to high levels of neutrophil mPR3 expression and thereby to the production of the inflammatory cytokine IL-1beta

  7. Computational methods identifyied H3(17-33)-derived peptides with improved binding affinity that would allow co-crystallization with the KDM6B catalytic core. A co-crystallized H3(17-33)A21M peptide had interactions between the KDM6B zinc binding domain and the H3(17-23) region. KDM6B uses the zinc binding domain to achieve H3K27me3/me2 specificity. A 1564 His-to-Gln substitution explains its higher affinity than KDM6A.

  8. Taken together, the authors propose that the miR-939-Jmjd3 axis perturbs the accessibility of hepatitis B virus enhancer II/core promoter (En II) promoter to essential nuclear factors (C/EBPalpha and SWI/SNF complex) therefore leading to compromised viral RNA synthesis and hence restricted viral multiplication.

  9. These results demonstrated that histone demethylase JMJD3 regulates CD11a expression in lupus T cells by affecting the H3K27me3 levels in the ITGAL (CD11a) promoter region, and JMJD3 might thereby serve as a potential therapeutic target for SLE.

  10. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.

  11. In this study, we showed that aberrantly upregulated JMJD3 exerts an anti-apoptotic effect in diffuse large B-cell lymphoma

  12. Our study therefore delineates KDM6B function that links NF-kappaB and MAPK signaling pathway mediating MM cell growth and survival, and validates KDM6B as a novel therapeutic target in MM.

  13. Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3.

  14. Here, we discuss the roles of lysine 27 demethylases, JMJD3 and UTX, in cancer and potential therapeutic avenues targeting these enzymes. Despite a high degree of sequence similarity in the catalytic domain between JMJD3 and UTX, numerous studies revealed surprisingly contrasting roles in cellular reprogramming and cancer, particularly leukemia

  15. inhibition of the H3K27 demethylase JMJD3 in naive CD4 T cells demonstrates how critically important molecules required for T cell differentiation, such as JAK2 and IL12RB2, are regulated by H3K27me3.

  16. KDM6B expression strongly correlates with ERbeta level in human pleural mesothelioma tumors and cell lines.

  17. Low JMJD3 expression is associated with breast cancer.

  18. Transient and forced expression of JMJD3c followed by the forced expression of lineage-defining transcription factors enabled the hPSCs to activate tissue-specific genes directly. Study have also shown that the introduction of JMJD3c facilitates the differentiation of hPSCs into functional hepatic cells and skeletal muscle cells.

  19. results demonstrate that the regulation of Jmjd3 by STAT3 maintains repression of differentiation specific genes and is therefore important for the maintenance of self-renewal of normal neural and glioblastoma stem cells

  20. Data show that histone demethylase JMJD3 was reduced and its target gene Snai1 expression was down-regulated after HOTAIR suppression.

Kdm6b Antigen Profile

Antigen Summary

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

Gene names and symbols associated with Kdm6b

  • lysine (K)-specific demethylase 6B (kdm6b) antibody
  • lysine demethylase 6B (KDM6B) antibody
  • lysine (K)-specific demethylase 6B, b (kdm6bb) antibody
  • KDM1 lysine (K)-specific demethylase 6B (Kdm6b) antibody
  • lysine demethylase 6B (Kdm6b) antibody
  • 1700064E03Rik antibody
  • BC038313 antibody
  • JMJD3 antibody
  • kdm6b antibody
  • mKIAA0346 antibody
  • si:ch211-237l4.7 antibody

Protein level used designations for Kdm6b

jumonji domain containing 3 , lysine (K)-specific demethylase 6B , jumonji domain containing 3, histone lysine demethylase , lysine-specific demethylase 6B-like , jmjC domain-containing protein 3 , jumonji domain-containing protein 3 , lysine-specific demethylase 6B , lysine demethylase 6B , jumonji domain-containing 3

779446 Xenopus (Silurana) tropicalis
468438 Pan troglodytes
563644 Danio rerio
716348 Macaca mulatta
100414637 Callithrix jacchus
100140276 Bos taurus
100343083 Oryctolagus cuniculus
216850 Mus musculus
23135 Homo sapiens
489481 Canis lupus familiaris
363630 Rattus norvegicus
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