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Lysophosphatidylcholine (LPC) acyltransferase (LPCAT\; EC 22.214.171.124) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 [PubMed 16704971]).[supplied by OMIM, May 2008].. Additionally we are shipping LPCAT1 Antibodies (55) and LPCAT1 Proteins (12) and many more products for this protein.
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Aruni, Lee, Osbourne, Dou, Roy, Muthiah, Boskovic, Fletcher: VimA-dependent modulation of acetyl coenzyme A levels and lipid A biosynthesis can alter virulence in Porphyromonas gingivalis. in Infection and immunity 2012
Show all 8 Pubmed References
The overexpression of LPCAT1 promotes the development and progression of ccRCC, likely through the conversion of LPC to PC.
We found a direct correlation between LPCAT1 mRNA copies and the amniotic fluid lamellar body count. This finding corroborates an association between LPCAT1 and surfactant phospholipid biosynthesis.
Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations are associated with Gastric Cancer
No disease causing mutations in the LPCAT1 gene were identified, indicating that LPCAT1 either does not confer a genetic predisposition to retinitis pigmentosa, or incidence of mutations in LPCAT1 is particularly rare in patients with retinitis pigmentosa.
Down-regulation of LPCAT1 resulted in a decreased intercellular platelet-activating factor concentration and PAFR (show PTAFR ELISA Kits) expression.
LPCAT1 is an independent predictor of early tumor recurrence of breast carcinoma and represents a novel prognostic biomarker that reflects underlying biological alterations
LPCAT1, a gene involved in the remodeling of phospholipids, was nominally associated with incident SCA risk.
The prognostic impact of LPCAT1 expression was independent of histological and clinical parameters. It is concluded, that LPCAT1 measurement, either alone or in combination, may be utilized for better clinical decision-making.
effect of LPCAT1 overexpression or knockdown on cell proliferation, migration, and invasion in hepatocellular carcinoma cell lines
LPCAT1 correlates with the progression of prostate cancer.
These results provide insight into understanding of the retinal degeneration seen in rd11 mice that lack LPCAT1.
LPCAT1 interacts with StarD10 and that amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction.
Almost wild-type LPCAT1 expression in photoreceptors with strong rod rhodopsin (show RHO ELISA Kits) and M/S cone opsin (show RHO ELISA Kits) staining, and normal visually-guided water maze behavioral performances were observed in treated rd11 mice.
Residue Cys (show DNAJC5 ELISA Kits)-211 of the conserved motif III is not essential for catalysis and not sufficient for sensitivity to treatment by sulfhydryl-modifier agents.
evidence of a protein substrate for Lpcat1 and reveal that histone lipidation may occur through its O-palmitoylation as a novel post-translational modification.
LPS (show TLR4 ELISA Kits) appears to destabilize the LPCAT1 protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP (show BTRC ELISA Kits) docking and site-specific ubiquitination.
Studies add another dimension to an essential role for LPCAT1 in retinal photoreceptor homeostasis.
full LPCAT1 activity is required to achieve the levels of SatPC essential for the transition to air breathing
acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1) is predominantly expressed in the lung, in particular in alveolar type II cells.
Results suggest that lysophosphatidylcholine acyltransferase (LPCAT (show LPCAT3 ELISA Kits)) plays a critical role in regulating surfactant phospholipid biosynthesis.
Lysophosphatidylcholine (LPC) acyltransferase (LPCAT\; EC 126.96.36.199) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006
acyltransferase like 2
, lysophosphatidylcholine acyltransferase 1
, 1-acylglycerophosphocholine O-acyltransferase
, 1-alkylglycerophosphocholine O-acetyltransferase
, LPC acyltransferase 1
, acetyl-CoA:lyso-PAF acetyltransferase
, acetyl-CoA:lyso-platelet-activating factor acetyltransferase
, acyltransferase-like 2
, lyso-PAF acetyltransferase
, lysoPC acyltransferase 1
, acyl-CoA:lysophosphatidylcholine acyltransferase 1
, phosphonoformate immuno-associated protein 3
, regulated by phosphonoformate