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MXD3 encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. Additionally we are shipping MAX Dimerization Protein 3 Proteins (10) and many more products for this protein.
Showing 10 out of 50 products:
Human Monoclonal MXD3 Primary Antibody for ISt, IHC - ABIN1304808
Barisone, Satake, Lewis, Duong, Chen, Lam, Nolta, Dίaz: Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells. in Blood cells, molecules & diseases 2015
Show all 4 Pubmed References
Cow (Bovine) Polyclonal MXD3 Primary Antibody for WB - ABIN2779271
Suzuki, Yoshitomo-Nakagawa, Maruyama, Suyama, Sugano: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. in Gene 1997
Human Polyclonal MXD3 Primary Antibody for ICC, IF - ABIN249679
Hurlin, Quéva, Koskinen, Steingrímsson, Ayer, Copeland, Jenkins, Eisenman: Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. in The EMBO journal 1996
The results suggest that MXD3 is important for survival of Reh (show CES1 Antibodies) preB (show PREB Antibodies) ALL cells, possibly as an anti-apoptotic factor.
Acute MXD3 activation results in a transient increase in DAOY cell proliferation while persistent activation of MXD3 results in an overall decrease in cell number, suggesting that the time course of MXD3 expression dictates the cellular outcome.
Increased level and/or duration of MXD3 expression ultimately reduces cell numbers via increased cell death and cell cycle arrest in medulloblastoma cells.
Mxd3 regulates preadipocyte proliferation and early adipocyte differentiation via Cebpd (show CEBPD Antibodies) downregulation in vitro and in vivo.
Results demonstrate that high expression levels of Mad3 in immature B cells induce Id2 expression, which inhibits transcription of genes essential for B cell differentiation.
identification as a novel target for regulation by E2F1 (show E2F1 Antibodies)
These studies support a novel role for Mad3 in cerebellar granule neuron precursors proliferation and possibly tumorigenesis.
Adenosine signaling mediates SUMO-1 (show SUMO1 Antibodies) modification of IkappaBalpha (show NFKBIA Antibodies) during hypoxia and reoxygenation.
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.
MAX dimerization protein 3
, Max-associated protein 3
, Max-interacting transcriptional repressor MAD3
, class C basic helix-loop-helix protein 13
, max dimerization protein 3
, max dimerizer 3
, max-associated protein 3
, max-interacting transcriptional repressor MAD3