MDS1 and EVI1 Complex Locus (MECOM) ELISA Kits

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping MDS1 and EVI1 Complex Locus Antibodies (117) and MDS1 and EVI1 Complex Locus Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Rat MECOM MECOM 294924  
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Top MDS1 and EVI1 Complex Locus ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
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Human
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$875.60
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More ELISA Kits for MDS1 and EVI1 Complex Locus Interaction Partners

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Letter/Case Report: ETV6 (show ETV6 ELISA Kits)/MECOM gene fusion in therapy-related acute myeloid leukemia (show BCL11A ELISA Kits) with t(3;12) and monosomy 7.

  2. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  3. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (show ETS1 ELISA Kits)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  4. The expression of EVI1 and SOX9 (show SOX9 ELISA Kits) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (show FRAP1 ELISA Kits) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (show FRAP1 ELISA Kits) targeting failure

  5. EVI1 contributes to PCa (show FLVCR1 ELISA Kits) progression by regulating different oncogenic functions. EVI1 regulates the PCa (show FLVCR1 ELISA Kits) stem cell compartment responsible for disease initiation and also development of CRPC.

  6. oncogenic potential for EVI1 in modulating genomic stability

  7. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  8. EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 (show CKMT1B ELISA Kits) expression by repressing the myeloid differentiation regulator RUNX1 (show RUNX1 ELISA Kits).

  9. EVI1 transcription is directly regulated by LEF1 (show LEF1 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) complex in myeloid blast crisis of chronic myeloid leukemia (show BCL11A ELISA Kits). Loss of p53 (show TP53 ELISA Kits) function as a key regulator for beta-catenin (show CTNNB1 ELISA Kits)-EVI1 in myeloid blast crisis of chronic myeloid leukemia (show BCL11A ELISA Kits).

  10. we demonstrated that miR (show MLXIP ELISA Kits)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1) mRNA is a direct target of miR (show MLXIP ELISA Kits)-22 and MECOM (EVI1) functions as a negative regulator in the differentiation.The miR (show MLXIP ELISA Kits)-22-mediated MECOM degradation increased c-Jun (show JUN ELISA Kits) but decreased GATA2 (show GATA2 ELISA Kits) expression, which results in increased interaction between c-Jun (show JUN ELISA Kits) and PU.1

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  2. Gata2 (show GATA2 ELISA Kits) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  3. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  4. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA ELISA Kits) from EVI1-induced suppression.

  5. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 ELISA Kits), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 ELISA Kits) levels.

  6. Survivin (show BIRC5 ELISA Kits) partially regulates HSC (show FUT1 ELISA Kits) function by modulating the Evi-1 transcription factor and its downstream targets

  7. Thrombopoietin (show THPO ELISA Kits)/MPL (show MPL ELISA Kits) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  8. Prdm16 (show PRDM16 ELISA Kits) and Prdm3 control postnatal BAT (show BAAT ELISA Kits) identity and function.

  9. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  10. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL ELISA Kits)) fusion protein (MFP) leukemia

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 ELISA Kits) signaling

  2. Prdm3 and prdm16 (show PRDM16 ELISA Kits) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi-1 (show RUNX1 ELISA Kits) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

MDS1 and EVI1 Complex Locus (MECOM) Antigen Profile

Antigen Summary

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (MECOM) antibody
  • MDS1 and EVI1 complex locus (Mecom) antibody
  • MDS1 and EVI1 complex locus (mecom) antibody
  • MDS1 and EVI1 complex locus L homeolog (mecom.L) antibody
  • AML1-EVI-1 antibody
  • D630039M04Rik antibody
  • evi-1 antibody
  • evi1 antibody
  • im:7140716 antibody
  • Jbo antibody
  • Mds antibody
  • Mds1 antibody
  • Mds1-Evi1 antibody
  • mecom antibody
  • mecom-a antibody
  • mecom-b antibody
  • prdm3 antibody
  • xEvi-1 antibody
  • Znfpr1b1 antibody

Protein level used designations for MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPECIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
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