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Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Additionally we are shipping Mannose Phosphate Isomerase Antibodies (102) and Mannose Phosphate Isomerase Kits (22) and many more products for this protein.
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This work provides mechanistic evidence by which mannose phosphate isomerase loss induces p53 (show TP53 Proteins), and identifies mannose phosphate isomerase as a novel regulator of p53 (show TP53 Proteins) and Warburg metabolism.
Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts
Data indicate that reduced phosphomannose isomerase (MPI) alters mannose flux in hypomorphic mice.
Phosphomannose isomerase activity and mRNA levels increased at 1 month, and the values in the ileum were lower than in jejunum.
Results suggest that mannose toxicity in phosphomannose isomerase(-/-) embryos is caused by mannose-6-P accumulation, which inhibits glucose metabolism and depletes intracellular ATP.
Data conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways.
MPI deficiencies resulted in 50% embryonic lethality by 4 dpf. Multi-systemic abnormalities, including small eyes, dysmorphic jaws, pericardial edema, a small liver and curled tails, occurred in 82% of the surviving larvae.
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
mannose-6- phosphate isomerase
, mannose-6-phosphate isomerase
, phosphomannose isomerase 1
, mannose phosphate isomerase 1
, phosphomannose isomerase
, mannosephosphate isomerase
, mannose phosphate isomerase
, mannose-6-phosphate isomerase-like
, Phosphomannose isomerase