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MAGEA4 is a member of the MAGEA gene family. Additionally we are shipping MAGEA4 Antibodies (82) and many more products for this protein.
Showing 5 out of 9 products:
a cleaved form of MAGE-A4 binds to Miz-1 (show ZBTB17 Proteins) and induces apoptosis
some autoantibodies, such as anti-MAGEA4, anti-CTAG1 (show CTAG1B Proteins) or anti-TP53 (show TP53 Proteins) and their combinations could possibly contribute to the development of cancer early detection tests (not necessarily restricted to gastric cancer) when being combined with other markers.
Anti-MAGEA4 exhibited the highest sensitivity for detecting early stage colorectal cancer (CRC (show CALR Proteins)) and advanced adenoma.
High MAGE-A4 expression is associated with Lung Cancer.
Results found concomitant overexpression of MAGEA4 and TWIST1 (show TWIST1 Proteins) in esophageal squamous cell carcinoma (ESCC). Also, it showed a correlation between MAGEA4 and TWIST1 (show TWIST1 Proteins) expression, which was found as indirect binding of TWIST1 (show TWIST1 Proteins) to the E-boxes in the MAGEA4 promoter revealing transcriptional upregulation of MAGEA4 by TWIST1 (show TWIST1 Proteins).
Results support the potential utility of NY-ESO-1 (show CTAG1B Proteins), PRAME (show PRAME Proteins), and MAGEA4 as targets for immunotherapy and as ancillary prognostic parameters in synovial sarcomas.
Data show that overall survival (OS) was significantly lower for patients expressing pan-MAGE (show MAGEB10 Proteins) or MAGE (show MAGEB10 Proteins)-A1/A3/A4 in both independent cohorts.
the crystal structures of MAGE-A3 (show MAGEA3 Proteins) and MAGE-A4
CTAs (MAGE-A4, NY-ESO-1, MAGE-A10) were more likely expressed in patients with squamous cell carcinoma of the lung and when CTAs combined with CD133, they can be better prognostic factors.
HLA class I (show MICA Proteins) loss in smokers or patients with the MAGE-A4 gene was a prognostic factors in non-small cell lung cancer .
Expression of MAGE-A4 may make immunotherapeutic intervention possible in selected patients with thyroid cancer.
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.
melanoma antigen family A, 4
, MAGE-4 antigen
, MAGE-41 antigen
, MAGE-X2 antigen
, cancer/testis antigen 1.4
, cancer/testis antigen family 1, member 4
, melanoma-associated antigen 4